DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and kirre

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	858	Identity:	171/858 - (19%)
Similarity:	286/858 - (33%)	Gaps:	226/858 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 EQTLQPGPAVSLKCSAAGNPTPQISWTLDGFPLPSNGRF-------MIGQYITVHGDVISHVNIS 488
            :||...|..|:|.|... .....:.||.|.|.|..:...       |:|.  ...||.  .::|.
  Fly    90 DQTAVVGSRVTLPCRVM-EKVGALQWTKDDFGLGQHRNLSGFERYSMVGS--DEEGDF--SLDIY 149

  Fly   489 HVMVEDGGEYACIA----ENRAGRVQHAARLNIYGLPYIRLIPKVT------AVSGETLNLKC-P 542
            .:|::|..:|.|..    :...|.....|:|.:...|.   .||:|      ......:.|:| .
  Fly   150 PLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPE---APKITQGDYLVTTEDREIELECVS 211

  Fly   543 VAGYPIEEIHWERG-GRELPDDIR---------QRVQPDGSLTISPVQKNSDSGVYTCWARNKQG 597
            ..|.|..||.|..| |..|...|.         :|:.....|.::| :|...:..:||.|:|...
  Fly   212 QGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAP-KKEHHNTTFTCQAQNTAD 275

  Fly   598 HSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVVKGDL---------PLTINWRKDGRP 653
            .:.|   ...:::..|.:|              .:..|||.|.|         .:.::.:.|..|
  Fly   276 RTYR---SAKLLLEVKYAP--------------KVIVSVVGGALAGGKIPEGAEVILSCQADANP 323

  Fly   654 IDPTQHMSVK---QVDQYNSILVIENLGSD-HTGNYSCVVRNSAAEVENSQALLVNVPPRWIVEP 714
            .:.:....:.   ....:.:.::|.|:... |.....|.|.|:..:.|.|:.|.::..|.:...|
  Fly   324 HELSYRWFINDELMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRP 388

  Fly   715 VDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTKLLGNGSLLLQHVKEDRE 779
            |....:....:.:.|...|.|.|.|.|......              :::|..:.|...|..:..
  Fly   389 VSVEADLGATVSMRCDVAGNPEPEIEWISENSD--------------QVVGVAAELKLKVSSETA 439

  Fly   780 GFYLCQA-NNGIGTGIGKVIQLKVNSSPYFSSTSRSVMV-KKGDTALLQC-AVSGDKPINIVWMR 841
            |.|.|:| .||. ..||....|.|..:|..  ||..|.. ..|....:.| |.|..|..:|:|..
  Fly   440 GRYFCKAVVNGF-PEIGAEATLYVKRAPII--TSHKVQFGGVGGRVKIDCLAFSIPKAEHILWSF 501

  Fly   842 SGKNTLNPSTNYKISVKQE-ATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEP 905
            .||.....|.:..|.:.:| ..|:||.|.|.||...||..|.|.|...|.||.|..::.| ::||
  Fly   502 EGKIINMSSADPDIYIFEEHHLPEGVRAALIIRDSKATHFGKYNCTVMNSYGGDSLVITL-LREP 565

  Fly   906 -------------------------------------PLPPSVLEAAMISSRSVN-IKWQPKTLG 932
                                                 |:|..|:..|......:| :|.:.::
  Fly   566 GNIPVLLVVMGSMFCVAIILMIVMIIIVYRKRRSRKKPMPADVIPEASRGGDKLNELKSELRS-- 628

  Fly   933 TGDVTKYIVEFREA----------DHSLPPALFVDQWQQIEVKDPPHFN---------------A 972
                ..|.||:.||          ...:|..........:.:..|..|:               .
  Fly   629 ----KAYDVEYSEAGGDGLAINLTQSPMPDVQMKGATLGVPLAGPVKFDERFSGDFGGDRYNRQC 689

  Fly   973 MIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLP 1037
            .|:|||.....|::    ||...:..:.......:...|.|...:           ::.....:.
  Fly   690 HIKNLKNQQETAYK----GSPQANGYAHYFEYALDYSPPGGEGAA-----------VVVGSGGVG 739

  Fly  1038 ELRHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVGPGP 1102
            :|::|.:....:.:..::         :|:|.|.|..|.   :.|.:..|:.:   ..:|...|.
  Fly   740 KLKNGGMNSATLPHSAAA---------TVNGGGAGNGGG---ASLPRNQRHEI---QQSQQSNGF 789

  Fly  1103 LSEP--------------------TAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPP------ 1141
            |.:|                    |.:..:..:|  ||.....||..:        |||
  Fly   790 LGQPLLQNGIDSRFSAIYGNPYLRTNSSLLPPLP--PPSTANPAATPA--------PPPYHAARH 844

  Fly  1142 --IYHTNGLLQGY 1152
              .:|.||.|:.:
  Fly   845 GHAHHANGGLKHF 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653	23/95 (24%)
		IGc2	436..507	CDD:197706	18/81 (22%)
		I-set	521..610	CDD:254352	24/105 (23%)
		IGc2	533..597	CDD:197706	19/74 (26%)
		Ig	630..699	CDD:143165	14/81 (17%)
		IG_like	714..802	CDD:214653	20/88 (23%)
		Ig	725..802	CDD:299845	18/77 (23%)
		Ig	823..894	CDD:143165	26/72 (36%)
		FN3	906..1006	CDD:238020	21/125 (17%)
		FN3	1013..1111	CDD:238020	15/117 (13%)
		FN3	1119..1209	CDD:238020	11/42 (26%)
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
kirre	NP_001245505.1	Ig	87..183	CDD:299845	23/97 (24%)
		IG_like	88..182	CDD:214653	23/96 (24%)
		C2-set_2	189..279	CDD:285423	22/90 (24%)
		Ig_2	307..379	CDD:290606	11/71 (15%)
		I-set	382..462	CDD:254352	21/94 (22%)
		IGc2	396..446	CDD:197706	12/63 (19%)
		Ig	466..561	CDD:299845	32/96 (33%)
		IG_like	478..561	CDD:214653	28/82 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810