DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and IGSF10

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:XP_011511010.1 Gene:IGSF10 / 285313 HGNCID:26384 Length:2695 Species:Homo sapiens


Alignment Length:986 Identity:251/986 - (25%)
Similarity:380/986 - (38%) Gaps:206/986 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 HLRGPGFVMEPPGRV------EFSNSSGGW--LDCSASGSPQPTVDWVHADGSAVTE-IHGVRR- 81
            ||.....|:..|.|:      |.:..||..  |.|.|.|.|.|||.|:.|:.:.|:| ..|.|: 
Human  1805 HLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQA 1869

  Fly    82 -VLRNGTLVLMPFAAAAYHQDVHNT------IYRCIASNSVGRIVSRDVQVRAVVAQAYKVDV-- 137
             |..:|||||            ||.      .|:|:|||..|: .|..|:::.:.|....::.  
Human  1870 VVTVDGTLVL------------HNLSIYDRGFYKCVASNPGGQ-DSLLVKIQVIAAPPVILEQRR 1921

  Fly   138 EVLSAARGCTAILRCVV-----PTFVKELVRVVSWVHEPAIYIYPSLQGDGKFHLLPTGELLIHN 197
            :|:....|.:..|.|..     |:        |.||......:.|....:.|..|...|.|.|.|
Human  1922 QVIVGTWGESLKLPCTAKGTPQPS--------VYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRN 1978

  Fly   198 LQESDESQSFRC---------RSMHRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQVSQDE 253
            |..||.. ::.|         |.:..||.:..|:|| |:...|.:            ..:|:..:
Human  1979 LASSDRG-TYECIATSSTGSERRVVMLTMEERVTSP-RIEAASQK------------RTEVNFGD 2029

  Fly   254 GAVLLCVAQGCPSPEYSW----------------FTH---NGAGPLPVLSGPRVRLLGPILAIEA 299
            ..:|.|.|.|.|.|:..|                :.|   ||:                 |.|.:
Human  2030 KLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS-----------------LFIGS 2077

  Fly   300 VTGEDSGVYKCTAGNVGGE----ASAELRLTVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSP 360
            ||.:|||||.|.|.|..|:    ....|||   .|.:::.........:.| .:|:....::|||
Human  2078 VTEKDSGVYLCVARNKMGDDLILMHVSLRL---KPAKIDHKQYFRKQVLHG-KDFQVDCKASGSP 2138

  Fly   361 VGMQNILW-YKDGRQLPSSGRVED--------------TLVVPRVSRENRGMYQCVVRRPEGDTF 410
            |  ..|.| ..||..:.::.:.:|              ||...:|.....|.|.|..:...|...
Human  2139 V--PEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDE 2201

  Fly   411 QATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKCSAAGNPTPQISWTLDGFPLPSNG--RFMIGQ 473
            .......:..||.:...:...:.::.|....|.|...|:|.|:|.|.     ||||.  .|.|.:
Human  2202 MKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWL-----LPSNDMISFSIDR 2261

  Fly   474 YITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAARLNIYGLPYI-------RLIPKVTA 531
            | |.|.:  ..:.|:.|.:.|.|||.|:|.|.:|......:|::...|.:       |.:.|.||
Human  2262 Y-TFHAN--GSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATA 2323

  Fly   532 VSGETLNLKCPVAGYPIEEIHWERGGRELPDDI---------RQRVQPDGSLTISPVQKNSDSGV 587
            |.....:..|...|.|..|:.|     .:||:|         |..|..:|:|.|..| :.|||..
Human  2324 VRHSKKHFDCRAEGTPSPEVMW-----IMPDNIFLTAPYYGSRITVHKNGTLEIRNV-RLSDSAD 2382

  Fly   588 YTCWARNKQGHSARRSGEVTVIV---------PPKLSPFQTNILQLNMGDRASLTCSVVKGDLPL 643
            :.|.|||:.|.|      |.|:.         |...:||...|: ..:|...:|.|| |.|:.|.
Human  2383 FICVARNEGGES------VLVVQLEVLEMLRRPTFRNPFNEKIV-AQLGKSTALNCS-VDGNPPP 2439

  Fly   644 TINWRKDGRPIDP--TQHMSVKQVDQY----NSILVIENLGSDHTGNYSCVVRNSAAEVENSQAL 702
            .|.|      |.|  |:..:..|..||    |...:|.....:..|.|.|..||....:|....|
Human  2440 EIIW------ILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVIL 2498

  Fly   703 LVNVPPRWIV-EPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTK---- 762
            .:...|..:. .|..........:.|||.:.|:|.|:|.|...:|       .|.:||...    
Human  2499 EIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSG-------YVVDRPQINGKYI 2556

  Fly   763 LLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSS-TSRSVMVKKGDTALLQ 826
            |..||:|:::.......|.|:|:|.|.:|..:..|..:.|...|..:: ..||::.:.|....|.
Human  2557 LHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLH 2621

  Fly   827 CAVSGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLY 891
            |...|.....|.|.....:.|:.::..:....::....|.   |.|:....:|||.|.|.|.|..
Human  2622 CVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGT---LVIQNPQTSDSGIYKCTAKNPL 2683

  Fly   892 GNDQQLVQLQV 902
            |:|.....:||
Human  2684 GSDYAATYIQV 2694

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845 30/84 (36%)
Ig 138..>203 CDD:299845 17/69 (25%)
I-set 238..327 CDD:254352 27/111 (24%)
Ig 247..327 CDD:299845 27/102 (26%)
I-set 332..418 CDD:254352 18/100 (18%)
IGc2 344..407 CDD:197706 17/77 (22%)
IG_like 432..517 CDD:214653 28/86 (33%)
IGc2 436..507 CDD:197706 26/72 (36%)
I-set 521..610 CDD:254352 31/104 (30%)
IGc2 533..597 CDD:197706 21/72 (29%)
Ig 630..699 CDD:143165 22/74 (30%)
IG_like 714..802 CDD:214653 24/91 (26%)
Ig 725..802 CDD:299845 23/80 (29%)
Ig 823..894 CDD:143165 17/70 (24%)
FN3 906..1006 CDD:238020
FN3 1013..1111 CDD:238020
FN3 1119..1209 CDD:238020
FN3 1219..1313 CDD:238020
Ig 1336..1402 CDD:143165
FN3 1409..1498 CDD:238020
FN3 1515..1588 CDD:238020
IGSF10XP_011511010.1 leucine-rich repeat 111..130 CDD:275380
leucine-rich repeat 131..154 CDD:275380
LRR_8 153..213 CDD:290566
leucine-rich repeat 155..178 CDD:275380
leucine-rich repeat 179..202 CDD:275380
LRR_8 201..267 CDD:290566
leucine-rich repeat 203..226 CDD:275380
leucine-rich repeat 227..250 CDD:275380
leucine-rich repeat 260..282 CDD:275380
LRRCT 291..>309 CDD:214507
IG_like 557..640 CDD:214653
Ig 559..627 CDD:299845
IG_like 654..734 CDD:214653
IGc2 659..724 CDD:197706
IG 1731..1812 CDD:214652 2/6 (33%)
Ig 1740..1812 CDD:299845 2/6 (33%)
IG_like 1825..1909 CDD:214653 33/96 (34%)
Ig 1832..1899 CDD:299845 28/78 (36%)
IG 1929..2005 CDD:214652 19/84 (23%)
IGc2 1929..1996 CDD:197706 18/75 (24%)
IG 2020..2097 CDD:214652 24/105 (23%)
IGc2 2028..2095 CDD:197706 22/83 (27%)
IG_like 2125..2208 CDD:214653 18/85 (21%)
Ig 2132..2208 CDD:299845 16/77 (21%)
I-set 2213..2296 CDD:254352 28/90 (31%)
IGc2 2228..2292 CDD:197706 26/71 (37%)
IG_like 2331..2402 CDD:214653 25/82 (30%)
Ig 2333..2402 CDD:299845 25/80 (31%)
IG 2417..2500 CDD:214652 25/90 (28%)
IGc2 2424..2490 CDD:197706 22/72 (31%)
IG_like 2511..2591 CDD:214653 23/86 (27%)
IGc2 2518..2585 CDD:197706 21/73 (29%)
Ig 2600..2694 CDD:299845 22/96 (23%)
IG_like 2607..2694 CDD:214653 21/89 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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