DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and CNTN6

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001276009.1	Gene:	CNTN6 / 27255	HGNCID:	2176	Length:	1028	Species:	Homo sapiens

Alignment Length:	1203	Identity:	285/1203 - (23%)
Similarity:	457/1203 - (37%)	Gaps:	286/1203 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 RLTRQVVVSSPTRLRINSHR--GIISPSVVEHTAH-----VQVSQDEGAVLLCVAQGCPSPEYSW 271
            ||..::|:..|.   |||..  |::|..:.....|     :.:|:.| .:|.|.|.|.|||.|.|
Human     2 RLLWKLVILLPL---INSSAGDGLLSRPIFTQEPHDVIFPLDLSKSE-VILNCAANGYPSPHYRW 62

  Fly   272 FTHNGAGPLPVLSGPRVRLLGPILAIEAV-TGEDSGVYKCTAGNVGG---EASAELRLTVATPIQ 332
             ..||. .:........||.|..|||.:. |.:|.|:|:|.|.|:.|   ...|:|:.......:
Human    63 -KQNGT-DIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFE 125

  Fly   333 VEISPNVLSVHMGGTAEFRC-----------LVTSNGSPVGMQNILWYKDGRQLPSSGRVEDT-- 384
            .: :.:.:||..|......|           ..|.|.:|:.:|     :|.|:..|    ::|
Human   126 TK-TRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQ-----EDNRRFVS----QETGN 180

  Fly   385 LVVPRVSRENRGMYQCVVRRPEGDTFQATAELQ-------------LGDAPPVLLYSFIEQTLQP 436
            |.:.:|...:.|.|.|.:...|     |...:|             :|:..|.:...|.| |:|.
Human   181 LYIAKVEPSDVGNYTCFITNKE-----AQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPE-TIQA 239

  Fly   437 G--PAVSLKCSAAGNPTPQISW-TLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEY 498
            .  .:|.|:|.|.|||.|.||| .|||.|||...::...|.|         :.|.:...||.|.|
Human   240 AKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAI---------LEIPNFQQEDEGFY 295

  Fly   499 ACIAENRAGRVQHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDD 563
            .|||.|..||.....:|..|..|                              .||
Human   296 ECIASNLRGRNLAKGQLIFYAPP------------------------------EWE--------- 321

  Fly   564 IRQRVQPDGSLTISPVQKNSDSGVY--TCWARNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNM 626
              |::|            |:...:|  ..|       ..:.||        |.:|:.|
Human   322 --QKIQ------------NTHLSIYDNLLW-------ECKASG--------KPNPWYT------- 350

  Fly   627 GDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRN 691
                                |.|:|..::|.:.:.::     |..|:|..|....:|.|.|...|
Human   351 --------------------WLKNGERLNPEERIQIE-----NGTLIITMLNVSDSGVYQCAAEN 390

  Fly   692 SAAEV-ENSQALLVNVPPRWIVEPVDAN--VERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYE 753
            ....: .|::..::...|.:...||...  |:....|::.|:....|..:|.||:.|       |
Human   391 KYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGT-------E 448

  Fly   754 EVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGT--GIGKVIQLKVNSSPYFSSTSRSVM 816
            .:|:.....||.:|||.:.::.....|.|.|.|.|..||  ..|.:|   |......:.....:.
Human   449 TLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLI---VKERTVITVPPSKMD 510

  Fly   817 VKKGDTALLQCAVSGDKPINI--VWMRSGKNTLNPSTNYKISVKQEATPDGVS----------AE 869
            |..|::.:|.|.||.|..|.:  ||..:|.         .|.:|:     ||:          .:
Human   511 VTVGESIVLPCQVSHDPSIEVVFVWFFNGD---------VIDLKK-----GVAHFERIGGESVGD 561

  Fly   870 LQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTG 934
            |.||.:....||.|.|.......:...:..:.|:.||.||..::...|||.:..:.|:
Human   562 LMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWR------- 619

  Fly   935 DVTKYIVEFREADHSLPPALFVDQ--------WQQI----EVKDPPHFNAMIENLKPATRYAFRV 987
                     ...|::.|..:|..|        ||.:    |:.:...:||.:..|.|...|.|||
Human   620 ---------AGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRV 675

  Fly   988 IAEGSAGRSAPSQ--ELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPELRHGDIQGYNVG 1050
            :|..|.|...||:  ||: ||:...|...|:::.....|.:||:|:|.:...||::|:..||.:.
Human   676 VAGNSIGIGEPSEPSELL-RTKASVPVVAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIM 739

  Fly  1051 YKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVGPGPLSEPTAAQTMEDV 1115
            ::  ..|:|.::...|| ..:..........:...:.:.|.|..:|..|.|.||..|...:.||.
Human   740 FR--PVGSTTWSKEKVS-SVESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDE 801

  Fly  1116 PSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLIFEPIIDDIQPS---KDEVESRKTTA 1177
            |...|......:.|:..::|||.........|.:.||::::  ..||.:.|   |..|....|
Human   802 PQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLY--WTDDSKESMIGKIRVSGNVT-- 862

  Fly  1178 LTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVP-EAPADI--KVVSSSSQSLYISW 1239
             |..:|||:..|.|...|.|:...|.|..|.|:...:::..| :.||:|  |:.:|   .|.::|
Human   863 -TKNITGLKANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNS---KLCLNW 923

  Fly  1240 --LPPNEPNGVITKYSLYTRVVNGRE------ELNNEKRSL--PSQQAYYEAKGLHPHMEYQFWV 1294
              :...|....:..|.:..|  ..|:      |.||....|  |.::            :|...:
Human   924 EHVKTMENESEVLGYKILYR--QNRQSKTHILETNNTSAELLVPFEE------------DYLIEI 974

  Fly  1295 TASTRVGEGKSSRVSSQITTNRIPARIISFGGP 1327
            ...:..|:|.||........:.:.:|.|.|..|
Human   975 RTVSDGGDGSSSEEIRIPKMSSLSSRGIQFLEP 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352	30/97 (31%)
		Ig	247..327	CDD:299845	29/83 (35%)
		I-set	332..418	CDD:254352	20/111 (18%)
		IGc2	344..407	CDD:197706	15/75 (20%)
		IG_like	432..517	CDD:214653	33/87 (38%)
		IGc2	436..507	CDD:197706	28/73 (38%)
		I-set	521..610	CDD:254352	10/90 (11%)
		IGc2	533..597	CDD:197706	7/65 (11%)
		Ig	630..699	CDD:143165	12/69 (17%)
		IG_like	714..802	CDD:214653	26/91 (29%)
		Ig	725..802	CDD:299845	23/78 (29%)
		Ig	823..894	CDD:143165	20/82 (24%)
		FN3	906..1006	CDD:238020	29/113 (26%)
		FN3	1013..1111	CDD:238020	23/97 (24%)
		FN3	1119..1209	CDD:238020	25/92 (27%)
		FN3	1219..1313	CDD:238020	22/106 (21%)
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
CNTN6	NP_001276009.1	Ig	26..118	CDD:325142	30/94 (32%)
		Ig	120..214	CDD:325142	20/108 (19%)
		Ig	227..315	CDD:325142	36/97 (37%)
		Ig	319..403	CDD:325142	25/153 (16%)
		Ig	424..496	CDD:325142	23/81 (28%)
		Ig	515..598	CDD:325142	21/96 (22%)
		FN3	598..691	CDD:238020	27/108 (25%)
		FN3	703..796	CDD:238020	23/95 (24%)
		FN3	805..898	CDD:238020	26/97 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..908		4/20 (20%)
		FN3	906..991	CDD:238020	21/101 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010