back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and Robo2

DIOPT Version :10

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	XP_006523098.1	Gene:	Robo2 / 268902	MGIID:	1890110	Length:	1598	Species:	Mus musculus

Alignment Length:	1782	Identity:	407/1782 - (22%)
Similarity:	652/1782 - (36%)	Gaps:	430/1782 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 VVRRP-EGDTFQATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKCSAAGNPTPQISWTLDG---- 460
            :.|.| :|..::..:.|:..|.||.::....:..:..|...:|.|.|.|.|||.|.|..||
Mouse    31 LTRTPWKGKPWKGGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVE 95

  Fly   461 ----------FPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGR-VQHAAR 514
                      ..|||...|.:.   .|||         .....|.|.|.|:|.|..|. |...|.
Mouse    96 TDKDDPRSHRMLLPSGSLFFLR---IVHG---------RRSKPDEGSYVCVARNYLGEAVSRNAS 148

  Fly   515 LNIYGL-PYIRLIP-KVTAVSGETLNLKC-PVAGYPIEEIHWERGGRELPDDIRQRVQ-PDGSLT 575
            |.:..| ...|..| .|...:||...|:| |..|:|...|:|::....: ||..:|:. ..|.|.
Mouse   149 LEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRI-DDKEERISIRGGKLM 212

  Fly   576 ISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKL--SPFQTNILQLNMGDRASLTCSVVK 638
            ||..:| ||:|:|||...|..|.......|:||...|..  .|....:|:   .:.....|. |:
Mouse   213 ISNTRK-SDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLE---EEAVEFRCQ-VQ 272

  Fly   639 GDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQALL 703
            ||...|:.|:||...: |.....:|  |.|.  |.|:...|...|.|.|:..|...:||.|..|.
Mouse   273 GDPQPTVRWKKDDADL-PRGRYDIK--DDYT--LRIKKAMSTDEGTYVCIAENRVGKVEASATLT 332

  Fly   704 VNV----PPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTK-- 762
            |.|    ||:::|.|.|..|.:.|.:...|:.:|.|.|::.|:| .||::..:....::|.::
Mouse   333 VRVRPVAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQK-EGSQNLLFPNQPQQPNSRCS 396

  Fly   763 LLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNS------SPYFSSTSRSVMVKKGD 821
            :...|.|.:.:::....|:|:|||....|:.:.|. ||:|..      .|.......:..:....
Mouse   397 VSPTGDLTITNIQRSDAGYYICQALTVAGSILAKA-QLEVTDVLTDRPPPIILQGPINQTLAVDG 460

  Fly   822 TALLQCAVSGDKPINIV-WMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFC 885
            ||||:|..:|: |:.:: |::.|...|  ..:.:.:::.:.|       |||:.:..:|:|.|.|
Mouse   461 TALLKCKATGE-PLPVISWLKEGFTFL--GRDPRATIQDQGT-------LQIKNLRISDTGTYTC 515

  Fly   886 RASNLYGNDQQLVQLQVQEP-------------PLPPSVLEAAMISSRSVNIKWQPKTLGTGDVT 937
            .|::..|.......|.|.|.             |.|||..:...:|..||.:.|||.|.|....:
Mouse   516 VATSSSGETSWSAVLDVTESGATISKNYDMNDLPGPPSKPQVTDVSKNSVTLSWQPGTPGVLPAS 580

  Fly   938 KYIVEFREADHSLPPALFVDQWQQI--EVKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSAPS- 999
            .||:|......|       :.||.:  .||...:   .:..|:|.|.|.|.|.|....|.|.||
Mouse   581 AYIIEAFSQSVS-------NSWQTVANHVKTTLY---TVRGLRPNTIYLFMVRAINPQGLSDPSP 635

  Fly  1000 -------QEL------IVRTEPQRPAGPPLSLSARP--LSSTELLISW-VAPLPELRHGDIQGYN 1048
                   |::      :...:.|:..|..:.....|  |:.|.:.::| |...|:.    ||||.
Mouse   636 MSDPVRTQDISPPAQGVDHRQVQKELGDVVVRLHNPVVLTPTTVQVTWTVDRQPQF----IQGYR 696

  Fly  1049 VGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVGPGPLSEPTAAQTME 1113
            |.|:.:|....:..:.::..........:|:: |.|...|.:.|:.:.....|..||....:|.|
Mouse   697 VMYRQTSGLQASTVWQNLDAKVPTERSAVLVN-LKKGVTYEIKVRPYFNEFQGMDSESKTVRTTE 760

  Fly  1114 DVPSRPPEDVRCAAL---SSQSLQVSWQPPPIYHTNGLLQGYKLIFEPIIDDIQPSKDEVESRKT 1175
            :.||.||:.|....:   :|.|:.|||.|||..|.||::|.||:.       ...::......||
Mouse   761 EAPSAPPQSVTVLTVGSHNSTSISVSWDPPPADHQNGIIQEYKIW-------CLGNETRFHINKT 818

  Fly  1176 ---TALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKP-----------LFCHSEEDVPEAPADIK 1226
               ...::|:.||.....|.::|.|.|..|.||.|:|           :...:...:.|...|:
Mouse   819 VDAAIRSVVIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGGRNEVVITENNNSITEQITDV- 882

  Fly  1227 VVSSSSQSLYIS------WLPPNEPNGVITKYS--LYTRVVNGREELNNEKRSLPSQQAYYEAKG 1283
                ..|..:|:      |:       ::..:|  ||.| ...|:.|:|...:.........:.|
Mouse   883 ----VKQPAFIAGIGGACWV-------ILMGFSIWLYWR-RKKRKGLSNYAVTFQRGDGGLMSNG 935

  Fly  1284 LHPHM------EYQF----WVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTL 1338
            ..|.:      .|.:    |...|..|....|.           |..|.:||       |..|..
Mouse   936 SRPGLLNAGDPNYPWLADSWPATSLPVNNSNSG-----------PNEIGNFG-------RGDVLP 982

  Fly  1339 PCTAVGKPKREWFKSDVALRQGGLHNSQLLDSGDLIISSLQLADGGNY-SCQV--DNGIGTDRLT 1400
            |....|.      |:...|..|.:::|....:.....||.|:.....| :.|:  .|.|
Mouse   983 PVPGQGD------KTATMLSDGAIYSSIDFTTKTTYNSSSQITQATPYATTQILHSNSI------ 1035

  Fly  1401 HTLIVQVPPTAPVLYVTSATSSSILMHWKCGF--------TGNAPITGYTLFYRRANGNTDEM-- 1455
            |.|.|.:|...   :.:|....:.||    ||        .||..:. |...||.|.|.::.|
Mouse  1036 HELAVDLPDPQ---WKSSVQQKTDLM----GFGYSLPDQNKGNNALL-YIPDYRLAEGLSNRMPH 1092

  Fly  1456 -------QLSRHASSHELKGLMCGSTYQIHLSAQN--KVGTSPTSTILHV--------RTQGQSP 1503
                   ..|.|.|| |..|.:.|.........:|  |...:..||..:|        ...|...
Mouse  1093 NQSQDFSTTSSHNSS-ERSGSLSGGKGGKKKKTKNSSKAQKNNGSTWANVPLPPPPVQPLPGTEL 1156

  Fly  1504 GHPASTALLAPNSTSLLVRLHSWPDNGCPLLYFVLQY---------------------RAVTDDP 1547
            ||.|:......:|           |:.||.|. |..|                     |.|...|
Mouse  1157 GHYAAEQENGYDS-----------DSWCPPLP-VQTYLHQGMEDELEEDEDRVPTPPVRGVASSP 1209

  Fly  1548 DAEWVLVSNA-LKPQRRIVINNLQPSTLYQLRMEAHNVAGISQA-EFNFVTLT---KDGDPPP-P 1606
            ...:...|.| |.|..|   ..:||      .::|| :..:::| :|:....|   :...||| |
Mouse  1210 AISFGQQSTATLTPSPR---EEMQP------MLQAH-LDELTRAYQFDIAKQTWHIQSNTPPPQP 1264

  Fly  1607 EIMHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIV------CYRHMLKNAPPLAEQSQIQ 1665
            .                    .|.:..|||...:.:...|      .....|:...||....|..
Mouse  1265 P--------------------APPLGYVSGALISDLETDVPDEDADDEEEPLEIPRPLRALDQTP 1309

  Fly  1666 KESLENRANS----------EAAQRERYYATIHKVSMQNNDKIPETSEDISPYATFQLSEAGGNM 1720
            ..|::|..:|          .|:..:|.::: |:.|:       .:|.|.|.:|:
Mouse  1310 GSSMDNLDSSVTGSMVNGWGSASDEDRNFSS-HRSSV-------GSSSDGSIFAS---------- 1356

  Fly  1721 SQPHHGGPANTLLHSFMYHERA--LAEGCSSPPPAASKNRRRHSRKTEPESEESESDQDQLTSSR 1783
                 |..|..|:.:   .::|  ..:|.|......:.:..:..|.|.|.|.:|.:...|..|.|
Mouse  1357 -----GSFAKALVAA---ADKAGFRLDGTSLTRTGKAFSSSQRQRPTSPFSTDSNTSAAQNQSQR 1413

  Fly  1784 TESSNQHE-GKIKHSIIYHGAQSSTSSDLSPMSEQKSLPRRGRSRYHHQQYQFSTNTTPRHHNSN 1847
            ...:.:|: |::....:....:.....||.|..:    |..|:..  .||...|      .|:.|
Mouse  1414 PRPTKKHKGGRMDPQPVLPHRREGMPDDLPPPPD----PPPGQGL--RQQIGLS------QHSGN 1466

  Fly  1848 KMNNNTTSNTNTTATNTTATPSTSSNSNKILSPRGGNLKSISSTFKSQDSIQCHIPTL------- 1905
            ..|                  ||....:.:...:..||:...|      |:.|...|:
Mouse  1467 VEN------------------STERKGSSLERQQAANLEDTKS------SLDCPAKTVLEWQRQT 1507

  Fly  1906 ---VKSPSISTQQQKQFHKQQL-------------------QNSSTNNSQHSSSNPNSSSLKQQQ 1948
               :.|.....:.:|..|||.:                   .:||..:|...|:.|..:.:.:..
Mouse  1508 QDWINSTERQEETRKAPHKQGVGSEESLVPYSKPSFPSPGGHSSSGTSSSKGSTGPRKADVLRGS 1572

  Fly  1949 PLLITPKLHQLEANGQELLGLDGIGNS 1975
                    ||..||  :||.:..:|::
Mouse  1573 --------HQRNAN--DLLDIGYVGSN 1589

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.