DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and Il1rap

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:XP_038943965.1 Gene:Il1rap / 25466 RGDID:2893 Length:697 Species:Rattus norvegicus


Alignment Length:661 Identity:127/661 - (19%)
Similarity:215/661 - (32%) Gaps:242/661 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   215 LTRQVVVSSPTRLRINSHRGIISPSVVEHTAH----------------VQVSQDEGAVLLCVAQG 263
            |.:.:|...|:.|  .||.|:.....| ..||                :||.:||.|.:.|    
  Rat     2 LQKFLVTGCPSSL--ESHLGLQYKGSV-RLAHFPSERCDDWGLDTMRQIQVFEDEPARIKC---- 59

  Fly   264 CPSP------EYSWFTHNGAG----------------PLPV-LSGPRVRLLGPILAIEAVTGEDS 305
               |      :|::.|.:.:|                |:.. |...|:.....:|........|:
  Rat    60 ---PLFEHFLKYNYSTAHSSGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDT 121

  Fly   306 GVYKCTAGNVGGEASAELRLT-----VATPIQVE------ISPNVLSVHM----GGTAEFRCLVT 355
            |.|.|.           ||.|     ||.|::|.      .||..|.||.    .|.....|...
  Rat   122 GNYTCM-----------LRNTTYCSKVAFPLEVVQKDSCFNSPMRLPVHRLYIEQGIHNITCPNV 175

  Fly   356 SNGSPVGMQ-NILWYKDGRQLPSSGRVED-----TLVVPRVSRENRGMYQCVVRRPE-GDTFQAT 413
            ....|..:: ::.|||...::.:...|:.     :..:|.||  |.|.|.|||...| |..|..|
  Rat   176 DGYFPSSVKPSVTWYKGCTEIVNFHNVQPKGMNLSFFIPLVS--NNGNYTCVVTYLENGRLFHLT 238

  Fly   414 AELQL------GDAPPVLLYSFIEQTL---QPGPAVSLKC----SAAGNPTPQISWTLDGFPLPS 465
            ..:.:      .||.|..:||..::.:   :||..:.:.|    |...:...:|.||:|| ..|.
  Rat   239 RTMTVKVVGSPKDAVPPHIYSPNDRVVYEKEPGEELVIPCKVYFSFIMDSHNEIWWTIDG-KKPD 302

  Fly   466 NGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAARLNIYGLPYIRLIPKVT 530
            :          |..|:..:.::|:...||        |.|.               .|..|.|||
  Rat   303 D----------VPVDITINESVSYSSTED--------ETRT---------------QILSIKKVT 334

  Fly   531 AVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARNK 595
                                          |:|:::.                    |.|.|||.
  Rat   335 ------------------------------PEDLKRN--------------------YVCHARNA 349

  Fly   596 QGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVV------KGDLPLTINWRK----- 649
            :|.:.:.:.....::||:.:      ::|..|..|::...||      ...|.:.:.:|.     
  Rat   350 EGEAEQAAKVKQKVIPPRYT------VELACGFGATVFLVVVLIVVYHVYWLEMVLFYRAHFGTD 408

  Fly   650 ----DGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAE-----------VENS 699
                ||:..|.....:....::...:|.:..:..:..|...|:....:..           ::.|
  Rat   409 ETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGNTVEAVFDFIQRS 473

  Fly   700 QALLVNVPPRWIVEPVDANVERNRHIMLHCQAQ-------------GVPTPSIV----------W 741
            :.::|.:.|.::.|...:.:|....:|  ||..             ..|.|.|:          |
  Rat   474 RRMIVVLSPDYVTEKSISMLEFKLGVM--CQNSIATKLIVVEYRPLEQPHPGIMQLKESVSFVSW 536

  Fly   742 K----KATGSK 748
            |    |.:|||
  Rat   537 KGEKSKHSGSK 547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845
Ig 138..>203 CDD:299845
I-set 238..327 CDD:254352 24/132 (18%)
Ig 247..327 CDD:299845 21/107 (20%)
I-set 332..418 CDD:254352 26/102 (25%)
IGc2 344..407 CDD:197706 17/73 (23%)
IG_like 432..517 CDD:214653 17/91 (19%)
IGc2 436..507 CDD:197706 17/74 (23%)
I-set 521..610 CDD:254352 13/88 (15%)
IGc2 533..597 CDD:197706 7/63 (11%)
Ig 630..699 CDD:143165 11/94 (12%)
IG_like 714..802 CDD:214653 13/62 (21%)
Ig 725..802 CDD:299845 12/51 (24%)
Ig 823..894 CDD:143165
FN3 906..1006 CDD:238020
FN3 1013..1111 CDD:238020
FN3 1119..1209 CDD:238020
FN3 1219..1313 CDD:238020
Ig 1336..1402 CDD:143165
FN3 1409..1498 CDD:238020
FN3 1515..1588 CDD:238020
Il1rapXP_038943965.1 Ig1_IL1R_like 37..144 CDD:409584 24/124 (19%)
Ig strand B 55..59 CDD:409584 1/3 (33%)
Ig strand C 79..83 CDD:409584 0/3 (0%)
Ig strand E 109..113 CDD:409584 1/3 (33%)
Ig strand F 123..128 CDD:409584 2/15 (13%)
Ig strand G 136..139 CDD:409584 1/2 (50%)
Ig 155..247 CDD:416386 23/93 (25%)
Ig strand A 157..162 CDD:409353 2/4 (50%)
Ig strand A 157..162 CDD:409353 2/4 (50%)
Ig strand B 168..172 CDD:409353 0/3 (0%)
Ig strand B 168..172 CDD:409353 0/3 (0%)
Ig strand C 186..191 CDD:409353 1/4 (25%)
Ig strand C 186..191 CDD:409353 1/4 (25%)
Ig strand C' 194..196 CDD:409353 0/1 (0%)
Ig strand C' 194..196 CDD:409353 0/1 (0%)
Ig strand D 201..205 CDD:409353 1/3 (33%)
Ig strand D 201..205 CDD:409353 1/3 (33%)
Ig strand E 207..212 CDD:409353 0/4 (0%)
Ig strand E 207..212 CDD:409353 0/4 (0%)
Ig strand F 221..230 CDD:409353 4/8 (50%)
Ig strand F 221..230 CDD:409353 4/8 (50%)
Ig strand G 233..246 CDD:409353 2/12 (17%)
Ig strand G 233..246 CDD:409353 2/12 (17%)
Ig3_IL1RAP 255..361 CDD:409525 32/189 (17%)
Ig strand B 274..278 CDD:409525 0/3 (0%)
Ig strand C 291..295 CDD:409525 1/3 (33%)
Ig strand E 326..330 CDD:409525 1/3 (33%)
Ig strand F 341..346 CDD:409525 2/24 (8%)
Ig strand G 353..356 CDD:409525 0/2 (0%)
TIR 416..559 CDD:214587 21/134 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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