DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and Cntn5

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:XP_036010831.1 Gene:Cntn5 / 244682 MGIID:3042287 Length:1434 Species:Mus musculus


Alignment Length:1326 Identity:311/1326 - (23%)
Similarity:531/1326 - (40%) Gaps:232/1326 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 ARGCTAILR-CVVPTFVKELVRVVSWVH---------EP-------AIYIYPSLQGDGKFHLLPT 190
            |.|.||..| |..|....|:|:   |.:         :|       ||.::|..: |..|.:   
Mouse   223 AHGHTAAERHCSEPDRPNEMVK---WKNVLDNKWYGPDPILIRSRGAICVFPQNE-DNPFWV--- 280

  Fly   191 GELLIHNLQESDESQSFRCRSMHRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQVSQDEGA 255
            .|.|...:| :|:..:    ::.||.....|::..|..:..:..|.:|: .:::..:.......|
Mouse   281 PERLTRKIQ-TDQGNT----NVPRLGDVQGVNNKERAALGDNVDISTPN-DDYSEALSGLSTSYA 339

  Fly   256 VLLCVAQGCPSPEYSWFTHNGAGPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNV--GGE 318
            .||.:.:...||       .|:...|..|.|.   ||.| ::...:...:.....:.||:  ..:
Mouse   340 ALLRIKKSSTSP-------FGSKSRPRFSSPS---LGTI-SVSPPSWRGAAQQYHSPGNLYHSSD 393

  Fly   319 ASAELRLTVATPIQVEISPNVLSVHMGGTAE--FRCLVTSNGSPVGMQNILWYKDGRQ--LPSSG 379
            |..:.......|:.|:...:|:........:  ..|.|..|.||    :..|.::|.:  |.|..
Mouse   394 AFRQDESVDYGPVFVQEPDDVIFPTDSDEKKVALNCEVRGNPSP----SYRWLRNGTEIALESDY 454

  Fly   380 R---VEDTLVVPRVSR-ENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIEQT-----LQ 435
            |   ::.|.::...|. .:.|:|||:.....|......|.||.     ..|.:|..:|     ::
Mouse   455 RYSLIDGTFIISNPSELRDSGLYQCLATNSFGSILSREATLQF-----AYLGNFSGRTRSAVSVR 514

  Fly   436 PGPAVSLKCSAAGNPTPQI--SWTLDGFP--LPSNGRFMIGQYITVHGDVISHVNISHVMVEDGG 496
            .|..|.|.||...: :|:|  ||..:.||  :..:.|..|.|       ...::.||.|...|.|
Mouse   515 EGQGVVLMCSPPPH-SPEIIYSWVFNEFPSFVAEDSRRFISQ-------ETGNLYISKVQTSDVG 571

  Fly   497 EYACIAENRA--GRV----------------QHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPV 543
            .|.|:.:|..  .||                ::..::.:: .|:     .|||..|.|:.::|..
Mouse   572 SYICLVKNAVTNARVLSPPTPLTLRNDGVMGEYEPKIEVH-FPF-----TVTAAKGTTVKMECFA 630

  Fly   544 AGYPIEEIHWERGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTV 608
            .|.|:..|.|.:....:|...|.| :....|.|..:|.: |:|:|.|.|.|.:|.::.| |::.:
Mouse   631 LGNPVPTITWMKVNGYIPSKSRLR-KSQAVLEIPNLQLD-DAGIYECTAENSRGKNSFR-GQLQI 692

  Fly   609 IVPP----KLSPFQTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYN 669
            ...|    ||     |..||:.|......|.......| |..|.|:|.|:.|.     .:||..|
Mouse   693 FTYPHWVQKL-----NDTQLDSGSPLQWECKATGKPRP-TYRWLKNGAPLLPQ-----SRVDTVN 746

  Fly   670 SILVIENLGSDHTGNYSCVVRNSAAEVENSQAL-LVNVPPRWIVEPVDAN--VERNRHIMLHCQA 731
            .||.|:::.....|.|.|:..|....:..|..| ::..||.:.:..|..:  |.::|.:::.|:.
Mouse   747 GILAIQSVNQSDAGMYQCLAENKYGAIYASAELKILASPPSFELNQVKKSIIVTKDRGVLIECEP 811

  Fly   732 QGVPTPSIVWKK----ATGSKSGEY-----EEVR-------------ERPFTKLLGNGSLLLQHV 774
            ||.|.|:|.|:|    ...:||..:     :..|             .|....:|.:|||.:.:.
Mouse   812 QGSPKPAISWRKGDKAVRANKSVSFFSTVVQRTRGTCVVMNGWGPKLARRRIAILPDGSLRILNA 876

  Fly   775 KEDREGFYLCQANNGIGTGIGKVI-QLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPINIV 838
            .:..||.|:||..|..|:  .::| .|.|........|.:...:..|::.:|.|....|..:::.
Mouse   877 SKADEGKYICQGVNIFGS--AEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVT 939

  Fly   839 --WMRSGKN-TLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQL 900
              |...|:. .......:..:::.:|:    ||:|.||.:....:|.|.||......:.....:|
Mouse   940 FYWTLKGQPIDFEKEGGHFENIRAQAS----SADLMIRNILLMHAGRYGCRVQTTADSVSDEAEL 1000

  Fly   901 QVQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQQIEVK 965
            .|:.||.||.|:....|:..:..:.|.|.|.....::.|.::.|..        |...||  .||
Mouse  1001 LVRGPPGPPGVVIVEEITESTATLSWSPATDNHSPISSYNLQARSP--------FSLGWQ--TVK 1055

  Fly   966 DPPHF------NAMIENLKPATRYAFRVIAEGSAGRSAPS-QELIVRTEPQRPAGPPLSLSARPL 1023
            ..|..      :||..:|.|...|.|||:|....|...|| ...::||....|...|.::|.|..
Mouse  1056 TVPEVITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSIPSRMIRTNEAVPKTAPSNVSGRSG 1120

  Fly  1024 SSTELLISWVAPLPELRHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKF--- 1085
            ...||:|:|.....|.::|:..||.|.::  .:|...:....|:.           |..:||   
Mouse  1121 RRHELVIAWEPVSEEFQNGEGFGYIVAFR--PNGTRGWKEKMVTS-----------SEASKFIYR 1172

  Fly  1086 -------ARYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIY 1143
                   ..:.|.|..:|..|.||.|:.....:.|..|:..|.||...::|...:.|.|:  .:.
Mouse  1173 DESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPTAAPTDVTATSVSVSEIFVVWK--HVK 1235

  Fly  1144 HTNGLLQGYKLIFEPIIDDIQPSKDEVESRKT--TALTMVLTGLRKYTNYSIQVLAHTRMGDGVV 1206
            .:.|..||:::.:   ..|.:| :|.||:.:|  ....::||||...|.|.:.|.|:...|.|..
Mouse  1236 ESLGRPQGFEISY---WKDTEP-EDSVETVRTRGNESFVMLTGLEGNTLYHLTVRAYNGAGYGPP 1296

  Fly  1207 SKPLFCHSEEDVP-EAPADIKVVSSSSQSLYISWLP--PNEPNGVITKYSLYTRVVNGREELNNE 1268
            |:.....::...| |.|.:::.....|| :.:.|.|  |......:..|.::.     |:|.::|
Mouse  1297 SREASTTTKRHPPREPPGNLRWEQQGSQ-VSLGWEPVRPLANESEVMGYKVFY-----RQEGHSE 1355

  Fly  1269 KRSLPSQQAYYEAKGLHPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWR 1333
            .:.:.:|    :.:.:.|..|...::.......||.....||||   |:|    |:.|..:...:
Mouse  1356 GQVIETQ----KPQAVVPLPEAGVYIIEVRAYSEGGDGTASSQI---RVP----SYSGGKITSAQ 1409

  Fly  1334 ST---------VTLPCTAVGKPKREW 1350
            ||         ||| ..|:..|...|
Mouse  1410 STLHSLSKWSSVTL-LLALMLPSSSW 1434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845
Ig 138..>203 CDD:299845 19/76 (25%)
I-set 238..327 CDD:254352 16/90 (18%)
Ig 247..327 CDD:299845 15/81 (19%)
I-set 332..418 CDD:254352 21/93 (23%)
IGc2 344..407 CDD:197706 16/70 (23%)
IG_like 432..517 CDD:214653 25/111 (23%)
IGc2 436..507 CDD:197706 22/76 (29%)
I-set 521..610 CDD:254352 26/88 (30%)
IGc2 533..597 CDD:197706 19/63 (30%)
Ig 630..699 CDD:143165 18/68 (26%)
IG_like 714..802 CDD:214653 28/112 (25%)
Ig 725..802 CDD:299845 25/99 (25%)
Ig 823..894 CDD:143165 15/73 (21%)
FN3 906..1006 CDD:238020 28/106 (26%)
FN3 1013..1111 CDD:238020 24/107 (22%)
FN3 1119..1209 CDD:238020 26/91 (29%)
FN3 1219..1313 CDD:238020 20/96 (21%)
Ig 1336..1402 CDD:143165 6/15 (40%)
FN3 1409..1498 CDD:238020
FN3 1515..1588 CDD:238020
Cntn5XP_036010831.1 Ig strand D 741..745 CDD:409353 2/3 (67%)
Ig strand E 747..752 CDD:409353 2/4 (50%)
Ig strand F 761..768 CDD:409353 2/6 (33%)
Ig strand G 772..781 CDD:409353 2/8 (25%)
Ig 786..903 CDD:416386 29/118 (25%)
Ig strand A 786..791 CDD:409353 1/4 (25%)
Ig strand A' 794..799 CDD:409353 0/4 (0%)
Ig strand B 803..810 CDD:409353 1/6 (17%)
Ig strand C 818..822 CDD:409353 1/3 (33%)
Ig strand D 865..868 CDD:409353 1/2 (50%)
Ig strand E 869..874 CDD:409353 3/4 (75%)
Ig strand F 882..890 CDD:409353 4/7 (57%)
Ig strand G 896..903 CDD:409353 2/6 (33%)
Ig 905..1006 CDD:416386 19/104 (18%)
Ig strand A 905..911 CDD:409353 0/5 (0%)
Ig strand A' 914..919 CDD:409353 0/4 (0%)
Ig strand B 922..930 CDD:409353 2/7 (29%)
Ig strand C 939..943 CDD:409353 0/3 (0%)
Ig strand D 964..967 CDD:409353 1/6 (17%)
Ig strand E 968..972 CDD:409353 2/3 (67%)
Ig strand F 981..988 CDD:409353 4/6 (67%)
Ig strand G 995..999 CDD:409353 0/3 (0%)
FN3 1006..1103 CDD:238020 28/106 (26%)
FN3 1111..1203 CDD:238020 24/104 (23%)
FN3 1213..1304 CDD:238020 26/96 (27%)
FN3 1311..1397 CDD:238020 20/98 (20%)
Integrase_Zn 26..62 CDD:396557
rve 78..172 CDD:395538
IN_DBD_C 243..288 CDD:395437 10/51 (20%)
Ig 404..499 CDD:416386 23/103 (22%)
Ig strand A 406..410 CDD:409353 1/3 (33%)
Ig strand A' 413..418 CDD:409353 1/4 (25%)
Ig strand B 424..432 CDD:409353 1/7 (14%)
Ig strand C 437..443 CDD:409353 2/9 (22%)
Ig strand C' 445..448 CDD:409353 1/2 (50%)
Ig strand D 455..459 CDD:409353 1/3 (33%)
Ig strand E 461..467 CDD:409353 1/5 (20%)
Ig strand F 474..483 CDD:409353 4/8 (50%)
Ig strand G 486..499 CDD:409353 4/17 (24%)
Ig 508..593 CDD:416386 24/92 (26%)
Ig strand A 509..514 CDD:409353 0/4 (0%)
Ig strand B 518..524 CDD:409353 2/5 (40%)
Ig strand C 532..538 CDD:409353 3/5 (60%)
Ig strand C' 543..545 CDD:409353 0/1 (0%)
Ig strand D 550..555 CDD:409353 2/4 (50%)
Ig strand E 558..562 CDD:409353 0/3 (0%)
Ig strand F 572..580 CDD:409353 2/7 (29%)
Ig strand G 582..593 CDD:409353 2/10 (20%)
Ig 606..693 CDD:416386 26/95 (27%)
Ig strand A 606..611 CDD:409353 0/4 (0%)
Ig strand A' 614..619 CDD:409353 2/9 (22%)
Ig strand B 622..631 CDD:409353 2/8 (25%)
Ig strand C 637..641 CDD:409353 1/3 (33%)
Ig strand C' 644..646 CDD:409353 0/1 (0%)
Ig strand D 654..657 CDD:409353 1/3 (33%)
Ig strand E 658..663 CDD:409353 1/4 (25%)
Ig strand F 671..679 CDD:409353 4/7 (57%)
Ig strand G 682..693 CDD:409353 3/11 (27%)
Ig 698..781 CDD:416386 26/93 (28%)
Ig strand A' 704..708 CDD:409353 1/3 (33%)
Ig strand B 712..720 CDD:409353 1/7 (14%)
Ig strand C 726..731 CDD:409353 2/4 (50%)
Ig strand C' 733..736 CDD:409353 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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