DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and Kirrel2

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:NP_766486.1 Gene:Kirrel2 / 243911 MGIID:2442334 Length:700 Species:Mus musculus


Alignment Length:675 Identity:150/675 - (22%)
Similarity:244/675 - (36%) Gaps:144/675 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   419 GDAPPVLLYSFIEQ----TLQPGPAVSLKCSAAGNPTPQISWTLDGF------PLPSNGRFMI-- 471
            |.:|     .|::|    .:..|....|.| |.|.....:.||.||.      .||...|:.|  
Mouse    18 GSSP-----HFLQQPEDMVVLLGEEARLPC-ALGAYRGLVQWTKDGLALGGERDLPGWSRYWISG 76

  Fly   472 ----GQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAARLNIYGLPYIRLI---PKV 529
                ||:         .::|..|.:||...|.|.| ::||.....|:|::...|....:   |.|
Mouse    77 NSASGQH---------DLHIKPVELEDEASYECQA-SQAGLRSRPAQLHVMVPPEAPQVLGGPSV 131

  Fly   530 TAVSGETLNLKCPVAG--YPIEEIHWERGGRELP-DDIRQRVQPD-------GSLTISPVQKNSD 584
            :.|:|...||.|...|  .|..|:.|.|.|..|. ....|....|       .:|.::| ..:.|
Mouse   132 SLVAGVPGNLTCRSRGDSRPAPELLWFRDGIRLDGSSFHQTTLKDKATGTVENTLFLTP-SSHDD 195

  Fly   585 SGVYTCWARNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVVKGDLPLT-INWR 648
            .....|.||::...:.|.:.....:..|.:.........:..|::.:..|... ...|:| ..|.
Mouse   196 GATLICRARSQALPTGRDTAVTLSLQYPPMVTLSAEPQTVQEGEKVTFLCQAT-AQPPVTGYRWA 259

  Fly   649 KDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQALLVNVPPRWIVE 713
            |.|.|:...:...::.|.....:          |...||.|.|:......|.||.|...|....:
Mouse   260 KGGSPVLGARGPRLEVVADATFL----------TEPVSCEVSNAVGSANRSTALEVLYGPILQAK 314

  Fly   714 PVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTKLLGNG-SLLLQHVKED 777
            |...:|:..:.....|..:|.|.|.|.|.:..||              ::|.:| :|.|..|..:
Mouse   315 PKSVSVDVGKDASFSCVWRGNPLPRITWTRMGGS--------------QVLSSGPTLRLPSVALE 365

  Fly   778 REGFYLCQA---NNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAV-SGDKPINIV 838
            ..|.|:|:|   ..|:|.|..:. :|.||:.|..::...:....:| .|.|||.| :...|.::|
Mouse   366 DAGDYVCRAEPRRTGLGGGKAQA-RLTVNAPPVVTALQPAPAFLRG-PARLQCVVFASPAPDSVV 428

  Fly   839 WMRSGKNTLNPSTNYKISVKQEATPD-------GVSAELQIRTVDATDSGPYF-CRASNLYGNDQ 895
            |... :..|...:..:..|:....|:       |:.:.|.|.....:|....| |.|.|..|..:
Mouse   429 WSWD-EGFLEAGSLGRFLVEAFPAPEVEGGQGPGLISVLHISGTQESDFTTGFNCSARNRLGEGR 492

  Fly   896 QLVQLQVQEPPLPPSVLEAAMISSRSVNIK----------WQPKTL------------------- 931
              ||:.:....|.|:|...|..:|.:.::.          |:..:|                   
Mouse   493 --VQIHLGRRDLLPTVRIVAGAASAATSLLMVITGVVLCCWRHGSLSKQKNLVRIPGSSEGSSSR 555

  Fly   932 ------GTGDVTKYIVEFREADHSLPPALFVDQWQQIEVKDPPHFNAMIENLKPATRYAFRVIAE 990
                  |:.:....||   ..|||   .|.:::.:.:|.|||.:           ..|..|.::.
Mouse   556 GPEEETGSSEDRGPIV---HTDHS---DLVLEEKEALETKDPTN-----------GYYRVRGVSV 603

  Fly   991 GSAGRSAPSQELIVRTEPQRPAGPP 1015
            ..:...||...|.:  .|..|.|.|
Mouse   604 SLSLGEAPGGGLFL--PPPSPIGLP 626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845
Ig 138..>203 CDD:299845
I-set 238..327 CDD:254352
Ig 247..327 CDD:299845
I-set 332..418 CDD:254352
IGc2 344..407 CDD:197706
IG_like 432..517 CDD:214653 27/100 (27%)
IGc2 436..507 CDD:197706 22/82 (27%)
I-set 521..610 CDD:254352 24/101 (24%)
IGc2 533..597 CDD:197706 19/73 (26%)
Ig 630..699 CDD:143165 13/69 (19%)
IG_like 714..802 CDD:214653 23/91 (25%)
Ig 725..802 CDD:299845 21/80 (26%)
Ig 823..894 CDD:143165 20/79 (25%)
FN3 906..1006 CDD:238020 23/134 (17%)
FN3 1013..1111 CDD:238020 2/3 (67%)
FN3 1119..1209 CDD:238020
FN3 1219..1313 CDD:238020
Ig 1336..1402 CDD:143165
FN3 1409..1498 CDD:238020
FN3 1515..1588 CDD:238020
Kirrel2NP_766486.1 IG 27..116 CDD:214652 26/99 (26%)
Ig 122..220 CDD:416386 23/98 (23%)
Ig strand A 123..126 CDD:409353 0/2 (0%)
Ig strand A' 129..133 CDD:409353 2/3 (67%)
Ig strand B 140..147 CDD:409353 3/6 (50%)
Cell attachment site. /evidence=ECO:0000255 146..148 0/1 (0%)
Ig strand C 153..158 CDD:409353 1/4 (25%)
Ig strand C' 161..163 CDD:409353 1/1 (100%)
Ig strand D 166..173 CDD:409353 1/6 (17%)
Ig strand E 180..188 CDD:409353 1/7 (14%)
Ig strand F 197..205 CDD:409353 2/7 (29%)
Ig strand G 211..217 CDD:409353 1/5 (20%)
Ig_3 223..292 CDD:404760 14/79 (18%)
Ig strand B 241..245 CDD:409353 0/3 (0%)
Ig strand C 255..259 CDD:409353 0/3 (0%)
Ig strand E 272..275 CDD:409353 0/2 (0%)
Ig strand F 281..290 CDD:409353 3/18 (17%)
Ig strand G 298..301 CDD:409353 0/2 (0%)
Ig 315..392 CDD:416386 23/91 (25%)
Ig strand A' 316..321 CDD:409353 0/4 (0%)
Ig strand B 324..333 CDD:409353 1/8 (13%)
Ig strand C 339..343 CDD:409353 1/3 (33%)
Ig strand C' 346..348 CDD:409353 0/1 (0%)
Ig strand D 351..354 CDD:409353 1/2 (50%)
Ig strand E 355..360 CDD:409353 1/4 (25%)
Ig strand F 368..376 CDD:409353 4/7 (57%)
Ig strand G 382..392 CDD:409353 3/10 (30%)
Ig 394..498 CDD:416386 24/107 (22%)
Ig strand A 395..399 CDD:409353 1/3 (33%)
Ig strand A' 401..404 CDD:409353 0/2 (0%)
Ig strand B 412..419 CDD:409353 4/6 (67%)
Ig strand C 426..431 CDD:409353 2/4 (50%)
Ig strand C' 433..436 CDD:409353 0/2 (0%)
Ig strand D 444..451 CDD:409353 1/6 (17%)
Ig strand E 461..468 CDD:409353 2/6 (33%)
Ig strand F 479..486 CDD:409353 3/6 (50%)
Ig strand G 489..496 CDD:409353 3/8 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..576 4/36 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 671..700
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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