DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and Sdk2

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_766388.2	Gene:	Sdk2 / 237979	MGIID:	2443847	Length:	2176	Species:	Mus musculus

Alignment Length:	1919	Identity:	457/1919 - (23%)
Similarity:	740/1919 - (38%)	Gaps:	430/1919 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 PIQVEISPNVLSVHMGGTAEFRCLVT--SNGS-PVGMQNILWYKDGRQLPSSGRVEDTLVVPRVS 391
            |...:..|....||:.|.   |.::|  :.|| |:..:   |..:.|:| :...:|...::..:.
Mouse    29 PPYFKTEPVRTQVHLEGN---RLVLTCMAEGSWPLEFK---WLHNNREL-TRFSLEYRYMITSLD 86

  Fly   392 RENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIE----QTLQPGPAVSLKCSAAGN-PT 451
            |.:.|.|:|:||...|...|...|:|:     ..:.||.|    |::..|.|..::.....: |.
Mouse    87 RTHAGFYRCIVRNRMGALLQRQTEVQV-----AYMGSFEEGEKRQSVNHGEAAVIRAPRISSFPR 146

  Fly   452 PQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIA------ENRAGRVQ 510
            ||::|..||..:|.:.|..    ||:...::    |...:..|.|.|...|      :|:..:..
Mouse   147 PQVTWFRDGRKIPPSSRIA----ITLENTLV----ILSTVAPDAGRYYVQAVNDKNGDNKTSQPI 203

  Fly   511 HAARLNIYG-----LPYIRLIPKVTAVSGET--LNLKCPVAGYPIEEIH--WERGGRELP---DD 563
            ..|..|:.|     .|.|.:.||.|:|...|  :.::|.....|:.::|  |::.|..|.   .|
Mouse   204 TLAVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTMECVANARPLIKLHIVWKKDGAPLSSGISD 268

  Fly   564 IRQRVQPDGSLTI-SPVQKNSDSGVYTCWA--RNKQGHSARRSGEVTVIVPPKLSPFQTNILQLN 625
            ..:|      ||| :|..  ||:|.|.|.|  |:.......|...::|:.||:........:...
Mouse   269 YNRR------LTIANPTV--SDAGYYECEAMLRSSSVAPVTRGAYLSVLEPPQFVREPERHITAE 325

  Fly   626 MGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVR 690
            |.....:.|. .||..|.:|.|.||...::..:....||  :.:..|.|..|..|.||...|...
Mouse   326 MEKVVDIPCR-AKGVPPPSITWYKDAALVEVGKLTRFKQ--RSDGGLQISGLLPDDTGMLQCFAH 387

  Fly   691 NSAAEVENSQALLV-NVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKK-----ATGSKS 749
            |:|.|.:.|..|.| ::.|.....|:|:.|.....::|.|:..|.|.|:|.|:|     |:||
Mouse   388 NAAGEAQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGS-- 450

  Fly   750 GEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRS 814
                 |:...|| ||.:||||:........|.|.|.|.|..|...... .|.|.:....:...:.
Mouse   451 -----VQLPRFT-LLESGSLLISPTHISDAGTYTCLATNSRGVDEASA-DLVVWARTRITKPPQD 508

  Fly   815 VMVKKGDTALLQCAVSGDKPINI--VWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDA 877
            ..|.||..|.:.|.|:.|..:.:  ||.:.|. ||...||.:|.:.:       :..|.|....:
Mouse   509 QSVIKGTQASMVCGVTHDPRVTVRYVWEKDGA-TLAVETNPRIRLDR-------NGSLHISQTWS 565

  Fly   878 TDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPS--VLEAAMISSRSVNIKWQPKTLGTGDVTKYI 940
            .|.|.|.||..:..|||.:...|:|::.|..|.  |...:.:..|::|:.|.....|...:.:|:
Mouse   566 GDIGTYTCRVLSAGGNDSRNAHLRVRQLPHAPEHPVATLSTVERRAINLTWAKPFDGNSPLMRYV 630

  Fly   941 VEFREADHSLPPALFVDQWQQIEVK-DPPHFNAMIENLKPATRYAFRVIAEGSAGR---SAPSQE 1001
            :|..|  ::.|       |..:... ||...:.|::.|.||..|.||:.|....|:   |..::.
Mouse   631 LEMSE--NNAP-------WTILLASVDPEATSVMVKGLVPARSYQFRLCAVNDVGKGQFSKDTER 686

  Fly  1002 LIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPELRHGDIQGYNVGYKLSSSGNTAYNFTSV 1066
            :.:..||  |..||.::.|...::..::|.|..|....::|.::||.:.|.|:.. ...|.|.::
Mouse   687 VSLPEEP--PTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGL-PVGYQFKNI 748

  Fly  1067 SGDGDGGNGELLLSGLAKFARYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQ 1131
            : |.|..|  |||..|..:..|.:.|.|:|..|.|..|......|::.||:.||.:|...|.:|.
Mouse   749 T-DADVNN--LLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNST 810

  Fly  1132 SLQVSWQPPPIYHTNGLLQGYKLI-FEPIIDDIQPSKDEVESRKTTALTMV-------------- 1181
            :::.:|..|.....||:.|||||| :||      ..::||        |||
Mouse   811 TIRFTWNAPSPQFINGINQGYKLIAWEP------AQEEEV--------TMVTARPNFQDSIHVGF 861

  Fly  1182 LTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPEAPADIKVVSSSSQSLYISWLPPNEPN 1246
            ::||:|:|.|...||..|..|||..|.|....:.||||.....:........||.:||..|.|.|
Mouse   862 VSGLKKFTEYFTSVLCFTTPGDGPRSSPQLVRTHEDVPGPVGHLSFNDILDTSLKVSWQEPGEKN 926

  Fly  1247 GVITKYSLYTRVVNGREELNNEK----RSLPSQQAYYEAKGLHPHMEYQFWVTASTRVGEGKSSR 1307
            |::|.|.:      ..||.|...    ..||:....|...||.....|...|.|.|..|:|   :
Mouse   927 GILTGYRI------SWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQG---Q 982

  Fly  1308 VSSQITTNRIPARI--------ISFGGP-----VVRPW--------RSTVTLPCTAVGKPKREWF 1351
            ||:...::.:|..:        ||..||     ..||.        |..|......:|:.: ||.
Mouse   983 VSASTISSGVPPELPGAPTNLGISNIGPRSVTLQFRPGYDGKTSISRWVVEAQVGVIGEGE-EWL 1046

  Fly  1352 KSDVALRQGGLHNSQLLDSGDLIISSLQLADGGN----YSCQVD--NGIGT------DRLTHTLI 1404
               :..:.|...:::.::..||           |    ||.::.  |.:||      .|...||
Mouse  1047 ---LIYQLGNEPDARSMEVPDL-----------NPFTYYSFRMRQVNIVGTSPPSQPSRKIQTL- 1096

  Fly  1405 VQVPPTAPVLYVT--SATSSSILMHW----KCGFTGNAPITGYTLFYRRANG------NTDEMQL 1457
             |.||......||  :|:.:|:.:.|    :..:.||....||.:.|.|::|      :|.:.::
Mouse  1097 -QAPPDIAPANVTLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYGRSDGHGKTLSHTVQDRV 1160

  Fly  1458 SRHASSHELKGLMCGSTYQIHLSAQNKVGTSPTSTILHVRTQGQSPGH-PASTALLAPNSTSLLV 1521
            .|..:..:|:.   .:.|::.:.|.|.:|:.|.|..:..||:...|.. |.:.:.||..|:|:||
Mouse  1161 EREYTIEDLEE---WTEYRVQVQAFNAIGSGPWSQAVVGRTRESVPSSGPTNVSALATTSSSMLV 1222

  Fly  1522 RLHSWPD---NGCPLLYFVLQYRAVTDDPDAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHN 1583
            |....|:   ||..|.|.|......:|.....|::..|:   .|...:..|....||::::.|..
Mouse  1223 RWSEIPEADRNGLVLGYKVRYKEKDSDSQPRFWLVEGNS---SRSAQLTGLGKYVLYEVQVLAFT 1284

  Fly  1584 VAGISQAEFNFVTLTKDGDPPPPEIMHRGRSG----QTTVIF-----ANINLLIPTIAAVSGMFC 1639
            ..|             ||.|..|.|:.|....    ...::|     .::.|:....||.:|
Mouse  1285 RIG-------------DGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNG--- 1333

  Fly  1640 TIIMIIVCYR--HMLKNA-----------PPLAEQ---SQIQKESL--------ENRANSEAAQ- 1679
                ||:.|:  |.| ||           .|.|.|   :.::.||:        ..:...|||:
Mouse  1334 ----IILAYQITHRL-NATTANTATVEVLAPSARQYMATGLKPESVYLFRITAQTRKGWGEAAEA 1393

  Fly  1680 -------RERYYATIHKVSMQNNDKIPET-------SEDISP--YATFQLSEAGGNMSQPHHGGP 1728
                   |:|.......|..|.:.|....       |:.:||  |.|.|..|.           |
Mouse  1394 LVVTTEKRDRPQPPSKPVVQQEDVKARSVLLSWEPGSDGLSPVRYYTIQTREL-----------P 1447

  Fly  1729 ANT-LLHSFMYHERALAEGCSSPPPAASKNRRRHSRKTEPESEESESDQDQLTSSRTE------- 1785
            :.. .|||......|.|.......|..|...|..:.....:||.|| :.:.||:.:..
Mouse  1448 SGRWALHSASVSHNASAFTVDRLKPFTSYKFRVKATNDIGDSEFSE-ESESLTTLQAAPDEAPTI 1511

  Fly  1786 -SSNQH-------------EGKIK----------HSIIYHGAQSSTS----------SDLSPMSE 1816
             |...|             |.||.          ..::|.|.:..|.          ::|:.:..
Mouse  1512 LSVTPHTTTSVLIRWQPPSEDKINGILLGFRIRYRELLYDGLRGFTLRGINNPGAKWAELTSLYS 1576

  Fly  1817 QKSLPRRGRSRYH------HQQYQ--------------------FSTNTTPRHHNSNKMNNNTTS 1855
            .::|.|...::|.      |::|:                    |.....|.....|...::.|:
Mouse  1577 MRNLTRPSLTQYELDNLSKHRRYEIRMSIYNAVGEGPLSPPQEVFVGEAVPTAAPQNVAIHSATA 1641

  Fly  1856 NTNTTATNTTATPSTSSNSNKILS---------PRGGNLKSISSTFKSQDSIQC----------- 1900
                |..:.|..|....|.|..:.         .|....:.:.:.|.:::|::.
Mouse  1642 ----TQLDVTWEPPPLDNQNGDIQGYKIYFWEVQRRNLTERVKTLFLAENSVKLKNLTGYTAYMV 1702

  Fly  1901 -------------HIPTLVKSPSISTQQQKQFHKQQLQNSSTNNSQHSSSNPNSSSLKQQQPL-- 1950
                         ..||..::...:..........:|..:|.|.|..:...||.       ||
Mouse  1703 SVAAFNAAGDGPRSTPTRGQTQQAAPSAPGSVKFSELTTTSVNVSWDAPQFPNG-------PLEG 1760

  Fly  1951 --LI----TPKLHQLEANG-QELLGLDGIGNSPL 1977
              |:    ||      .:| .:::.:|..|||||
Mouse  1761 YRLVYEPCTP------VDGVSKIVTVDVKGNSPL 1788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352	22/88 (25%)
		IGc2	344..407	CDD:197706	16/65 (25%)
		IG_like	432..517	CDD:214653	20/91 (22%)
		IGc2	436..507	CDD:197706	18/77 (23%)
		I-set	521..610	CDD:254352	28/98 (29%)
		IGc2	533..597	CDD:197706	20/73 (27%)
		Ig	630..699	CDD:143165	20/68 (29%)
		IG_like	714..802	CDD:214653	30/92 (33%)
		Ig	725..802	CDD:299845	27/81 (33%)
		Ig	823..894	CDD:143165	20/72 (28%)
		FN3	906..1006	CDD:238020	24/105 (23%)
		FN3	1013..1111	CDD:238020	27/97 (28%)
		FN3	1119..1209	CDD:238020	34/104 (33%)
		FN3	1219..1313	CDD:238020	27/97 (28%)
		Ig	1336..1402	CDD:143165	14/77 (18%)
		FN3	1409..1498	CDD:238020	22/100 (22%)
		FN3	1515..1588	CDD:238020	20/75 (27%)
Sdk2	NP_766388.2	IG_like	44..113	CDD:214653	19/75 (25%)
		IGc2	44..102	CDD:197706	16/64 (25%)
		IG_like	124..207	CDD:214653	19/90 (21%)
		Ig	136..192	CDD:299845	15/63 (24%)
		IG_like	226..308	CDD:214653	24/89 (27%)
		IGc2	237..290	CDD:197706	17/60 (28%)
		I-set	312..401	CDD:254352	24/91 (26%)
		Ig	330..398	CDD:143165	21/70 (30%)
		I-set	406..496	CDD:254352	31/98 (32%)
		Ig	420..496	CDD:299845	27/84 (32%)
		Ig	506..590	CDD:299845	26/91 (29%)
		IG_like	506..590	CDD:214653	26/91 (29%)
		FN3	594..685	CDD:238020	24/99 (24%)
		FN3	697..790	CDD:238020	27/96 (28%)
		FN3	798..894	CDD:238020	35/109 (32%)
		FN3	899..987	CDD:238020	27/96 (28%)
		FN3	997..1091	CDD:238020	20/108 (19%)
		FN3	1103..1198	CDD:238020	21/97 (22%)
		FN3	1205..1294	CDD:238020	26/104 (25%)
		FN3	1305..1398	CDD:238020	20/100 (20%)
		FN3	1404..1488	CDD:238020	19/94 (20%)
		FN3	1507..1620	CDD:238020	14/112 (13%)
		FN3	1630..1723	CDD:238020	12/96 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1712..1734		2/21 (10%)
		FN3	1728..1809	CDD:238020	18/74 (24%)
		FN3	1841..1920	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2013..2032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2043..2070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2102..2176
		PDZ-binding. /evidence=ECO:0000269\|PubMed:20219992	2170..2176
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810