DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and Ntm

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001344522.1	Gene:	Ntm / 235106	MGIID:	2446259	Length:	367	Species:	Mus musculus

Alignment Length:	352	Identity:	84/352 - (23%)
Similarity:	140/352 - (39%)	Gaps:	57/352 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   602 RSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVVKGDLPLT-INW---------RKDGRPIDP 656
            |||:.|.       |...:.:.:..|:.|:|.|::   |..:| :.|         ..|...:||
Mouse    32 RSGDATF-------PKAMDNVTVRQGESATLRCTI---DNRVTRVAWLNRSTILYAGNDKWCLDP 86

  Fly   657 TQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQALLVNVPPRWIVEPVDANVER 721
            ...:......||:  :.|:|:.....|.|:|.|:.......:...|:|.|.|:.:....|.::..
Mouse    87 RVVLLSNTQTQYS--IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINE 149

  Fly   722 NRHIMLHCQAQGVPTPSIVWK----KATGSKS-GEYEEVRERPFTKLLGNGSLLLQHVKEDREGF 781
            ..:|.|.|.|.|.|.|::.|:    ||.|..| .||.|:                |.:..::.|.
Mouse   150 GNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEI----------------QGITREQSGE 198

  Fly   782 YLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPINIVWMRSGKNT 846
            |.|.|:|.:...:.:.:::.||..||.|. ::...|..|....|||..|........|.:..|..
Mouse   199 YECSASNDVAAPVVRRVKVTVNYPPYISE-AKGTGVPVGQKGTLQCEASAVPSAEFQWFKDDKRL 262

  Fly   847 LNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPSV 911
            :..    |..||.|..|  ..::|....|...|.|.|.|.|||..|:....:.|.....|...::
Mouse   263 VEG----KKGVKVENRP--FLSKLTFFNVSEHDYGNYTCVASNKLGHTNASIMLFELNEPTSSTL 321

  Fly   912 LEAAMISSRSVNIKWQPKTLGTGDVTK 938
            |:....::.:   .|:    |.|.|::
Mouse   322 LQEVKTTALT---PWK----GPGAVSE 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653
		IGc2	436..507	CDD:197706
		I-set	521..610	CDD:254352	4/7 (57%)
		IGc2	533..597	CDD:197706
		Ig	630..699	CDD:143165	17/78 (22%)
		IG_like	714..802	CDD:214653	22/92 (24%)
		Ig	725..802	CDD:299845	21/81 (26%)
		Ig	823..894	CDD:143165	21/70 (30%)
		FN3	906..1006	CDD:238020	6/33 (18%)
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Ntm	NP_001344522.1	Ig	44..132	CDD:416386	19/92 (21%)
		Ig strand A'	44..49	CDD:409353	0/4 (0%)
		Ig strand B	51..59	CDD:409353	3/7 (43%)
		CDR1	59..63	CDD:409353	1/6 (17%)
		FR2	64..70	CDD:409353	2/5 (40%)
		Ig strand C	64..70	CDD:409353	2/5 (40%)
		CDR2	71..83	CDD:409353	1/11 (9%)
		Ig strand C'	72..76	CDD:409353	0/3 (0%)
		Ig strand C'	80..83	CDD:409353	1/2 (50%)
		FR3	84..118	CDD:409353	9/35 (26%)
		Ig strand D	87..94	CDD:409353	0/6 (0%)
		Ig strand E	97..103	CDD:409353	2/7 (29%)
		Ig strand F	110..118	CDD:409353	3/7 (43%)
		CDR3	119..123	CDD:409353	0/3 (0%)
		Ig strand G	123..132	CDD:409353	1/8 (13%)
		FR4	125..132	CDD:409353	1/6 (17%)
		Ig_3	136..205	CDD:404760	22/84 (26%)
		Ig strand A'	144..148	CDD:409353	1/3 (33%)
		Ig strand B	151..160	CDD:409353	3/8 (38%)
		Ig strand F	197..205	CDD:409353	4/7 (57%)
		Ig_3	222..299	CDD:404760	23/83 (28%)
		putative Ig strand A	223..229	CDD:409353	3/6 (50%)
		Ig strand B	239..243	CDD:409353	1/3 (33%)
		Ig strand C	252..256	CDD:409353	0/3 (0%)
		Ig strand E	278..282	CDD:409353	1/3 (33%)
		Ig strand F	292..297	CDD:409353	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900