DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and Igsf9b

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	XP_011240777.1	Gene:	Igsf9b / 235086	MGIID:	2685354	Length:	1443	Species:	Mus musculus

Alignment Length:	1663	Identity:	340/1663 - (20%)
Similarity:	556/1663 - (33%)	Gaps:	522/1663 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 PNVLSVHMGGTAEFRC----LVTSNGSPVGMQNILWYKDGRQLP---------------SSGRV- 381
            |..::...|.....||    .||....|..::   |:|.|..:|               .:||.
Mouse    32 PEFVTARAGEGVVLRCDVIHPVTGQPPPYVVE---WFKFGVPIPIFIKFGYYPPHVDPEYAGRAS 93

  Fly   382 ---EDTLVVPRVSRENRGMYQCVVRR--PEGDTFQATAELQLG-DAPPVLLYS---FIEQTLQPG 437
               :.:|.:.:|..|::|.|:|.|..  .:.|||...:.:.|. :|||....:   :||  .:.|
Mouse    94 LHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIE--AKEG 156

  Fly   438 PAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIA 502
            .::::.|:|.|||.|.::|..:|..|.::.::.:..         ..:.::.|..||.|.|.|.|
Mouse   157 GSITMTCTAFGNPKPIVTWLKEGTLLGASAKYQVSD---------GSLTVTSVSREDRGAYTCRA 212

  Fly   503 ENRAGRVQHAARLNIYGLPYIRLIPK-VTAVSGETLNLKCPVAGYP---IEEIHWERGGRELPDD 563
            .:..|...|...|.:.|.|:|...|: :|....:...|.|....||   ....:|:.......:|
Mouse   213 YSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQND 277

  Fly   564 IRQRVQ--PDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPK---LSPFQTNILQ 623
            ::.||:  .||:|.|..| |..|:|.|||...|..|.|...|..:||..|.:   :.|    ::.
Mouse   278 LKLRVRILIDGTLIIFRV-KPEDAGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPP----VIY 337

  Fly   624 LNMGDRASLTCSVVKGDLPLT-INWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSC 687
            :.:|....:.|. |..:.|.| :.|.|||||:         ||:        :|||
Mouse   338 VPVGIHGYIRCP-VDAEPPATVVKWNKDGRPL---------QVE--------KNLG--------- 375

  Fly   688 VVRNSAAEVENSQALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEY 752
                                                                 |
Mouse   376 -----------------------------------------------------W----------- 376

  Fly   753 EEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGT-GIGKVIQLKVNSSPYFS-STSRSV 815
                     .|:.:||:.::...|:..|.|.|...|.:|| |.....:|.:...|||: ......
Mouse   377 ---------TLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEY 432

  Fly   816 MVKKGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDS 880
            ..:.|...|:.||.:||....|.|.:.||    ||.:     |..|.|.|   .||.|.:...|.
Mouse   433 RQEAGRELLIPCAAAGDPFPVITWRKVGK----PSRS-----KHNALPSG---SLQFRALSKEDH 485

  Fly   881 GPYFCRASNLYGNDQQLVQLQV--QEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYI--- 940
            |.:.|.|:|:..:......|.|  ..|..|.||  ...:|..:.|:.|:|...|..:.|..:
Mouse   486 GEWECVATNVVTSITASTHLTVIGTSPHAPGSV--RVHVSMTTANVSWEPGYDGGYEQTFSVWYG 548

  Fly   941 -----VEFREADHSLPPALFVDQWQQIEVKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSAPSQ 1000
                 .:|...|           |..:.|...|.: .::::|:|.|.|.|.|:|:...|.||.|:
Mouse   549 PLMKRAQFGPHD-----------WLSLSVPPGPSW-LLVDSLEPETAYQFSVLAQNRLGTSAFSE 601

  Fly  1001 ELIVRT--------EPQRPAGPPLSLSARPLSSTELLISWVAP----LPELRHGDIQGYNVG--- 1050
            .:.|.|        ||.....||..|:|. .:...:|:||:.|    .|..|:  |..:.||
Mouse   602 VVTVNTLAFPVTTPEPLVLVTPPRCLTAN-RTQQGVLLSWLPPANHSFPIDRY--IMEFRVGERW 663

  Fly  1051 --------------YKLSSSGNTAYNF-------------TSVSGDG-----------DGGNGEL 1077
                          :....|.:|.|.|             ::::|..           |.|....
Mouse   664 EMLDDAIPGTDGDFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTDDGLARP 728

  Fly  1078 LLSGLAKFARYTVVVQAFNQVG----------------PGPLSEPTAAQTMEDVPSR---PPEDV 1123
            :|:|:.....:......|:.:.                ..|||.....:::|...|.   .||.:
Mouse   729 VLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSGKVSPESI 793

  Fly  1124 RCAALSSQSLQVSWQP------PPIYHTNGLLQGYKLIFEPIID-DIQPSKDEVESRKTTALTMV 1181
            |.....|:|.....||      .|.....  |..||.....|.. ....:|.|.|:..||.:.::
Mouse   794 RTLRAPSESSDDQGQPAAKRMLSPTREKE--LSLYKKTKRAISSRKYSVAKAEAEAEATTPIELI 856

  Fly  1182 LTGL-RKYTNYSIQVLAHTRMGDGVVSK--------------PLFCHSEED-----VPEAPADIK 1226
            ..|. .::      |:..:.|...|..:              |.|..|:|:     ||.:.|.:|
Mouse   857 SRGPDGRF------VMGPSEMEPSVKGRRIEGFPFAEETDMYPEFRQSDEENEDPLVPTSVAALK 915

  Fly  1227 ---VVSSSSQSLYI---SWLPPNEPNGVITKYSLYTRVVNGREELNNEKRSLPSQQAYYEAKGLH 1285
               ...||||..|:   ::.|..:|.|:.....|     .||.:...:.|. |:.:.:
Mouse   916 PQLTPMSSSQDSYLPPPAYSPRFQPRGLEGPSGL-----GGRLQATGQARP-PAPRPF------- 967

  Fly  1286 PHMEYQFWVTAST------------RVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWR----S 1334
            .|.:|..::::|:            .||...||.:||.......|     ||.|.:....    |
Mouse   968 QHGQYYGYLSSSSPGEVEPPPFYMPEVGSPLSSVMSSPPLHTEGP-----FGHPTIPEENGENAS 1027

  Fly  1335 TVTLPCTAV---GKPKREWFKSDVALRQGGLHNSQLLDSGDL----IISSLQLADGGNYSCQVDN 1392
            ..|||.|..   |:....|.:.:...  |||....::....|    :..|||     ..:| :..
Mouse  1028 NSTLPLTQTPTGGRSPEPWGRPEFPF--GGLETPAMMFPHQLHPCDVAESLQ-----PKAC-LPR 1084

  Fly  1393 GIGTDRLTHTLIVQVPPTAPVLYVTSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQL 1457
            |:              |.|| |.|.:|....:.:....|:.|.:|..|
Mouse  1085 GL--------------PPAP-LQVPAAYPGMLSLEAPKGWVGKSPGRG----------------- 1117

  Fly  1458 SRHASSHELKGLMCGSTYQIHLSAQNKVGTSPTSTILHVRTQGQSPGHPASTALLAPNSTSLLVR 1522
                              .|......|....|...::   :|||          |...|..:.:.
Mouse  1118 ------------------PIPAPPATKWQERPMQPLV---SQGQ----------LRHTSQGMGIP 1151

  Fly  1523 LHSWPD------NGCPLLYFVLQYRAVTDDPDAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEA 1581
            :..:|:      :|.|..:.:          |..|.......:|..| .....:|| |:|:.::.
Mouse  1152 VLPYPEPAEPGGHGGPSTFGL----------DTRWYEPQPRPRPSPR-QARRAEPS-LHQVVLQP 1204

  Fly  1582 HNVAGISQAEFNFVTLTKDGDP-------PPPEIMHRGRSGQTTVIFANINLLIPTIAAVSGMFC 1639
            ..::.::|:..:    ::.|.|       |.|.::.:....:.|        |.|. ||||
Mouse  1205 SRLSPLTQSPLS----SRTGSPELAARARPRPGLLQQAEMSEIT--------LQPP-AAVS---- 1252

  Fly  1640 TIIMIIVCYRHMLKNAPPLAEQSQIQKESLENRANSEAAQRERYYATIHKVSMQNNDKIPETSED 1704
                      ...|:.|     |.....|..:|:.|.:     |..|:...::...  .|.....
Mouse  1253 ----------FSRKSTP-----SSTGSPSQSSRSGSPS-----YRPTMGFTTLATG--YPSPPPG 1295

  Fly  1705 ISPYATFQLSEAGGNMSQPHHGG-------PANTLLHSFMYHERALAEGCSSPPPAAS------- 1755
            .:|.|.....:..|....|...|       |..||..|          |...|.|..:
Mouse  1296 PAPPAPGDTLDVFGQTPSPRRMGEEPLRPEPPTTLPTS----------GILPPAPGNAAVPERLE 1350

  Fly  1756 ----------KNRRRHSRKTEPESEESESDQDQLTSSR 1783
                      |...:.|.|::..|:.|.|...||.||:
Mouse  1351 ALRYQRIKKPKKSSKGSSKSKKRSDGSASQAQQLPSSQ 1388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352	23/105 (22%)
		IGc2	344..407	CDD:197706	19/87 (22%)
		IG_like	432..517	CDD:214653	20/84 (24%)
		IGc2	436..507	CDD:197706	17/70 (24%)
		I-set	521..610	CDD:254352	29/94 (31%)
		IGc2	533..597	CDD:197706	20/68 (29%)
		Ig	630..699	CDD:143165	15/69 (22%)
		IG_like	714..802	CDD:214653	13/88 (15%)
		Ig	725..802	CDD:299845	13/77 (17%)
		Ig	823..894	CDD:143165	23/70 (33%)
		FN3	906..1006	CDD:238020	26/107 (24%)
		FN3	1013..1111	CDD:238020	26/158 (16%)
		FN3	1119..1209	CDD:238020	21/111 (19%)
		FN3	1219..1313	CDD:238020	25/111 (23%)
		Ig	1336..1402	CDD:143165	15/72 (21%)
		FN3	1409..1498	CDD:238020	13/88 (15%)
		FN3	1515..1588	CDD:238020	12/78 (15%)
Igsf9b	XP_011240777.1	Ig	43..117	CDD:319273	17/76 (22%)
		I-set	141..227	CDD:369462	23/96 (24%)
		Ig	231..323	CDD:386229	27/92 (29%)
		Ig	<355..416	CDD:386229	25/159 (16%)
		Ig	440..504	CDD:319273	23/75 (31%)
		FN3	512..607	CDD:238020	27/108 (25%)
		FN3	623..705	CDD:238020	17/84 (20%)
		PHA03247	<900..1248	CDD:223021	83/460 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810