DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and IGSF9B

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:NP_001264214.1 Gene:IGSF9B / 22997 HGNCID:32326 Length:1437 Species:Homo sapiens


Alignment Length:1634 Identity:347/1634 - (21%)
Similarity:573/1634 - (35%) Gaps:468/1634 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   337 PNVLSVHMGGTAEFRC----LVTSNGSPVGMQNILWYKDGRQLP---------------SSGRV- 381
            |..::...|.:...||    .||....|..::   |:|.|..:|               .:||. 
Human    30 PEFVTARAGESVVLRCDVIHPVTGQPPPYVVE---WFKFGVPIPIFIKFGYYPPHVDPEYAGRAS 91

  Fly   382 ---EDTLVVPRVSRENRGMYQCVVRR--PEGDTFQATAELQLG-DAPPVLLYS---FIEQTLQPG 437
               :.:|.:.:|..|::|.|:|.|..  .:.|||...:.:.|. :|||....:   :||  .:.|
Human    92 LHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIE--AKEG 154

  Fly   438 PAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIA 502
            .::::.|:|.|||.|.::|..:|..|.::|::.:..         ..:.::.|..||.|.|.|.|
Human   155 GSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSD---------GSLTVTSVSREDRGAYTCRA 210

  Fly   503 ENRAGRVQHAARLNIYGLPYIRLIPK-VTAVSGETLNLKCPVAGYP---IEEIHWERGGRELPDD 563
            .:..|...|...|.:.|.|:|...|: :|....:...|.|....||   ....:|:.......:|
Human   211 YSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQND 275

  Fly   564 IRQRVQ--PDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPK---LSPFQTNILQ 623
            ::.||:  .||:|.|..| |..|||.|||...|..|.|...|..:||..|.:   :.|    ::.
Human   276 LKLRVRILIDGTLIIFRV-KPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPP----VIY 335

  Fly   624 LNMGDRASLTCSVVKGDLPLT-INWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSC 687
            :.:|....:.|. |..:.|.| :.|.|||||:...:::....::  :..:.||....:..|.|:|
Human   336 VPVGIHGYIRCP-VDAEPPATVVKWNKDGRPLQVEKNLGWTLME--DGSIRIEEATEEALGTYTC 397

  Fly   688 VVRNSAAEVENS--QALLVNVPPRWIVEP-VDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKS 749
            |..|:...:..|  ..|::..||.:.|.| .:...|..|.:::.|.|.|.|.|.|.|:| .|..|
Human   398 VPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRK-VGKPS 461

  Fly   750 GEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKV-NSSPY------ 807
                    |.....|.:|||..:.:.::..|.:.|.|.| :.|.|.....|.| .:||:      
Human   462 --------RSKHSALPSGSLQFRALSKEDHGEWECVATN-VVTSITASTHLTVIGTSPHAPGSVR 517

  Fly   808 --FSSTSRSVMVKKGDTALLQCAVSGDKPINIVWMRSGK--------------------NTLNPS 850
              .|.|:.:|..:.|..       .|.:....|||:..:                    :||.|.
Human   518 VQVSMTTANVSWEPGYD-------GGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPE 575

  Fly   851 TNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPL---PPSVL 912
            |.|:.||..: ...|.||..::.||: |.:.|                 :...||.:   ||..|
Human   576 TAYQFSVLAQ-NKLGTSAFSEVVTVN-TLAFP-----------------ITTPEPLVLVTPPRCL 621

  Fly   913 EAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQQIEVKDP---PHFNAMI 974
             .|..:.:.|.:.|.|....:..:.:||:|||.|          ::|:.::...|   ..|.|  
Human   622 -IANRTQQGVLLSWLPPANHSFPIDRYIMEFRVA----------ERWELLDDGIPGTEGEFFA-- 673

  Fly   975 ENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPEL 1039
            ::|...|.|.|||:        |..|:||  :||...||         :|||::.     |.|:|
Human   674 KDLSQDTWYEFRVL--------AVMQDLI--SEPSNIAG---------VSSTDIF-----PQPDL 714

  Fly  1040 RHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVG----- 1099
            .                              :.|....:|:|:.....:......|:.:.     
Human   715 T------------------------------EDGLARPVLAGIVATICFLAAAILFSTLAACFVN 749

  Fly  1100 -----------PGPLSEPTAAQTMEDVPSR---PPEDVRCAALSSQSLQVSWQP------PPIYH 1144
                       ..|||.....:::|...|.   .||.:|.....|:|.....||      .|...
Human   750 KQRKRKLKRKKDPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSESSDDQGQPAAKRMLSPTRE 814

  Fly  1145 TNGLLQGYKLIFEPIID-DIQPSKDEVESRKTTALTMVLTG---------------LRKYTNYSI 1193
            ..  |..||.....|.. ....:|.|.|:..||.:.::..|               |:.......
Human   815 KE--LSLYKKTKRAISSKKYSVAKAEAEAEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGF 877

  Fly  1194 QVLAHTRMGDGVVSKPLFCHSEED-----VPEAPADIK---VVSSSSQSLYI---SWLPPNEPNG 1247
            .....|.|      .|.|..|:|:     ||.:.|.:|   ...||||..|:   ::.|..:|.|
Human   878 PFAEETDM------YPEFRQSDEENEDPLVPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRG 936

  Fly  1248 VITKYSLYTRVVNGREELNNEKRSLPSQQAYYEAKGLHPHMEYQFWVTAST------------RV 1300
            :.....|     .||.:...:.|. |:.:.::       |.:|..::::|:            .|
Human   937 LEGPGGL-----EGRLQATGQARP-PAPRPFH-------HGQYYGYLSSSSPGEVEPPPFYVPEV 988

  Fly  1301 GEGKSSRVSSQITTNRIPARIISFGGPVVRPWR----STVTLPCTAV---GKPKREWFKSDVALR 1358
            |...||.:||.......|     ||.|.:....    |..|||.|..   |:....|.:.:... 
Human   989 GSPLSSVMSSPPLPTEGP-----FGHPTIPEENGENASNSTLPLTQTPTGGRSPEPWGRPEFPF- 1047

  Fly  1359 QGGLHNSQLLDSGDL----IISSLQLADGGNYSCQVDNGIGTDRLTHTLIVQVPPTAPVLYVTSA 1419
             |||....::....|    :..|||...|      :..|:             |||:  |.|.:|
Human  1048 -GGLETPAMMFPHQLPPCDVPESLQPKAG------LPRGL-------------PPTS--LQVPAA 1090

  Fly  1420 TSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQ--LSRHASSHELKGLMCGSTYQIHLSAQ 1482
            ....:.:....|:.|.:|..|.......|......||  :|:....|..:|:             
Human  1091 YPGILSLEAPKGWAGKSPGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGM------------- 1142

  Fly  1483 NKVGTSPTSTILHVRTQGQSPGHPASTALLAPNSTSLLVRLHSWPDNGCPLLYFVLQYRAVTDDP 1547
             .:...|.          ..|..|.:               |..|.               |...
Human  1143 -GIPVLPY----------PEPAEPGA---------------HGGPS---------------TFGL 1166

  Fly  1548 DAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHNVAGISQAEFNFVTLTKDGDP-------PP 1605
            |..|.......:|..| .....:|| |:|:.::...::.::|:..:    ::.|.|       |.
Human  1167 DTRWYEPQPRPRPSPR-QARRAEPS-LHQVVLQPSRLSPLTQSPLS----SRTGSPELAARARPR 1225

  Fly  1606 PEIMHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYRHMLKNAPPLAEQSQIQKESLE 1670
            |.::.:....:.|        |.|. ||||              ...|:.|.....||      .
Human  1226 PGLLQQAEMSEIT--------LQPP-AAVS--------------FSRKSTPSTGSPSQ------S 1261

  Fly  1671 NRANSEAAQRERYYATI-----------------HKVSMQNNDKIP-ETSEDI----SPYATF-- 1711
            :|:.|.:.:....:.|:                 ..:.:......| .|.|::    :|..|.  
Human  1262 SRSGSPSYRPAMGFTTLATGYPSPPPGPAPAGPGDSLDVFGQTPSPRRTGEELLRPETPPPTLPT 1326

  Fly  1712 --QLSEAGGNMSQPHHGGPANTLLHSFMYHERALAEGCSSPPPAASKNRRRHSRKTEPESEESES 1774
              .|..|.||.:.|..       |.:..|..       ...|..:||.    |.|::..|::|.|
Human  1327 SGTLPPAPGNAAAPER-------LEALKYQR-------IKKPKKSSKG----SSKSKKRSDDSAS 1373

  Fly  1775 DQDQLTSSR 1783
            ...||.:|:
Human  1374 QTQQLPNSQ 1382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845
Ig 138..>203 CDD:299845
I-set 238..327 CDD:254352
Ig 247..327 CDD:299845
I-set 332..418 CDD:254352 23/105 (22%)
IGc2 344..407 CDD:197706 19/87 (22%)
IG_like 432..517 CDD:214653 21/84 (25%)
IGc2 436..507 CDD:197706 18/70 (26%)
I-set 521..610 CDD:254352 30/94 (32%)
IGc2 533..597 CDD:197706 21/68 (31%)
Ig 630..699 CDD:143165 17/69 (25%)
IG_like 714..802 CDD:214653 25/88 (28%)
Ig 725..802 CDD:299845 22/76 (29%)
Ig 823..894 CDD:143165 18/90 (20%)
FN3 906..1006 CDD:238020 27/105 (26%)
FN3 1013..1111 CDD:238020 14/113 (12%)
FN3 1119..1209 CDD:238020 21/111 (19%)
FN3 1219..1313 CDD:238020 25/111 (23%)
Ig 1336..1402 CDD:143165 15/72 (21%)
FN3 1409..1498 CDD:238020 16/90 (18%)
FN3 1515..1588 CDD:238020 11/72 (15%)
IGSF9BNP_001264214.1 IG_like 30..115 CDD:214653 19/87 (22%)
Ig 41..115 CDD:143165 17/76 (22%)
I-set 139..225 CDD:254352 24/96 (25%)
IGc2 153..210 CDD:197706 17/65 (26%)
I-set 229..321 CDD:254352 28/92 (30%)
Ig 235..321 CDD:299845 26/86 (30%)
IG_like 331..414 CDD:214653 20/89 (22%)
Ig <353..414 CDD:299845 16/62 (26%)
IG_like 426..505 CDD:214653 25/88 (28%)
Ig 442..505 CDD:299845 22/72 (31%)
FN3 510..601 CDD:238020 21/99 (21%)
FN3 617..699 CDD:238020 29/104 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 758..817 13/60 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 911..1081 42/208 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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