DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and SDK1

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:2027 Identity:478/2027 - (23%)
Similarity:772/2027 - (38%) Gaps:459/2027 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   278 GPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNVGGEASAEL------------------- 323
            ||.|  |.||.       |.|...|:.:|     ||..||..:|:|                   
Human    45 GPEP--SRPRA-------APETSGGDTAG-----AGRCGGRRAAKLGPGRRGWWALLALQLHLLR 95

  Fly   324 ---RLTVATPIQVEISPNVLSVHMGGTAEFRCLVT--SNGS-PVGMQNILWYKDGRQLPSSGRVE 382
               :..||...:.|  |.:..:|:.|.   |.::|  :.|| |:..:   |.:|..:|.:... |
Human    96 ALAQDDVAPYFKTE--PGLPQIHLEGN---RLVLTCLAEGSWPLEFK---WMRDDSELTTYSS-E 151

  Fly   383 DTLVVPRVSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIE----QTLQPGPAVSLK 443
            ...::|.:.:.:.|.|:||||...|...|..:|:|:     ..:.||::    :|:..|.|..|.
Human   152 YKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEVQV-----AYMGSFMDTDQRKTVSQGRAAILN 211

  Fly   444 -CSAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIA----- 502
             ......|.||::|..:|..:..:.|..    ||:...::    |......|.|.|...|     
Human   212 LLPITSYPRPQVTWFREGHKIIPSNRIA----ITLENQLV----ILATTTSDAGAYYVQAVNEKN 268

  Fly   503 -ENRAGRVQHAARLNIYGLPYIR----LIP----KVTAVSGETLNLKCPVAGYPIEE--IHWERG 556
             ||:.....|.:.....|.|...    ::|    .|.|.|.|| .|:|..:..|:|:  :.|:|.
Human   269 GENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSET-TLECIASARPVEDLSVTWKRN 332

  Fly   557 GRELPDDIRQRVQPDGSLTIS-PVQKNSDSGVYTCWAR--NKQGHSARRSGEVTVIVPPKLSPFQ 618
            |..:...:....:   .|||| |.  ::|:|.|.|.|.  ......||.:..:.:|.||..:...
Human   333 GVRITSGLHSFGR---RLTISNPT--SADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEP 392

  Fly   619 TNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTG 683
            .:.:...:.:...:.|..:...|| |:.|.||...|...|:...|.:  .:..|.|:.|..:.:|
Human   393 ESRISAEVEETVDIGCQAMGVPLP-TLQWYKDAISISRLQNPRYKVL--ASGGLRIQKLRPEDSG 454

  Fly   684 NYSCVVRNSAAEVENSQAL-LVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKK---- 743
            .:.|...|...|::....| :.|:.|.:...|||..|......:|.|:..|.|.|:|.||:    
Human   455 IFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHI 519

  Fly   744 -ATGSKSGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPY 807
             |:||       || .|...||.:|.|.:..|.....|.|.|.|.|..|:         :|:|..
Human   520 LASGS-------VR-IPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGS---------LNASAT 567

  Fly   808 FSSTSRSVMVK--------KGDTALLQCAVSGDKPINI--VWMRSGKNTLNPSTNYKISVKQEAT 862
            .:..:|:.:|.        ||.||.|.|..:.|..:::  ||.:... .|.||:..:|.|:::.:
Human   568 LTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNV-ALTPSSTSRIVVEKDGS 631

  Fly   863 PDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAMISSRS--VNIK 925
                   |.|....:.|.|.|.|...:..|||.::.:|:|.|.|..|..|..:..||.|  |.:.
Human   632 -------LLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLS 689

  Fly   926 WQPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQ-QIEVKDPPHFNAMIENLKPATRYAFRVIA 989
            |.....|...:..||||..|.:         ..|: .:....|......:..|.||..|.|||.|
Human   690 WVRPFDGNSPILYYIVELSENN---------SPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCA 745

  Fly   990 EGSAGR---SAPSQELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPELRH-GDIQGYNVG 1050
            ....||   ||.:..|::..||  |:.||.::.|...::..:::.|..| ||..| |.::||.:.
Human   746 VNEVGRGQYSAETSRLMLPEEP--PSAPPKNIVASGRTNQSIMVQWQPP-PETEHNGVLRGYILR 807

  Fly  1051 YKLSSSGNTAYNFTSVSGDGDGGN------GELLLSGLAKFARYTVVVQAFNQVGPGPLSEPTAA 1109
            |:|:          .:.|:....|      ...|::.|..:.:|.:.|.|:|..|.|..|.....
Human   808 YRLA----------GLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTE 862

  Fly  1110 QTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLIFEPIIDDIQPSKDEVESRK 1174
            .|::.||:.||::|:..|::|.::|..|.|||....||:.|||||:..|        .|..|:  
Human   863 YTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWP--------ADAPEA-- 917

  Fly  1175 TTALTMV----------LTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPEAPADIKVVS 1229
            .|.:|:.          :|.|:|:|.|...||..|..|||..|.|....::||.|.|...:....
Human   918 VTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTE 982

  Fly  1230 SSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREELNNEKR---SLPSQQAYYEAKGLHPHMEYQ 1291
            ....||.:||..|.|.||:||.|.:...|. ||    |:.|   :|.|....|:.:||.....|.
Human   983 ILDTSLKVSWQEPLEKNGIITGYQISWEVY-GR----NDSRLTHTLNSTTHEYKIQGLSSLTTYT 1042

  Fly  1292 FWVTASTRVGEG--KSSRVSSQI-------TTNRIPARI------ISF-----GGPVVRPWRSTV 1336
            ..|.|.|.||.|  .||.:||.:       .:|.:.:.|      :.|     |...:..|  .|
Human  1043 IDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRW--IV 1105

  Fly  1337 TLPCTAVGKPKREWFKSDVAL-RQGGLHNSQLLDSGDLI--------ISSLQLADGGNYSCQVDN 1392
            .....|:| .:.||    |.| .:....::|:|:..:|.        :..:.:.....||     
Human  1106 EGQVGAIG-DEEEW----VTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYS----- 1160

  Fly  1393 GIGTDRLTHTLIVQVPP-TAPV-LYVTSATSSSILMHW----KCGFTGNAPITGYTLFYRRANGN 1451
              .:.|:..||  |.|| .||. :.|.:|:.:|:.:.|    ...:.||....||.:.|.|::..
Human  1161 --PSSRVIQTL--QAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQ 1221

  Fly  1452 TDEM------QLSRHASSHELKGLMCGSTYQIHLSAQNKVGTSPTSTILHVRTQGQSP-GHPAST 1509
            :..:      :|.|..:..||:..|   .|::.:.|.|.||..|.|.::..||:...| ..|.:.
Human  1222 SSAVAQVVSDRLEREFTIEELEEWM---EYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENV 1283

  Fly  1510 ALLAPNSTSLLVRLHSWPD---NGCPLLYFVLQYRAVTDDPDAEWVLVSNALKPQRRIVINN--- 1568
            :..|.:||.:|:...|.|:   ||..|.|.:| :||...||:           |:..||..|   
Human  1284 SAEAVSSTQILLTWTSVPEQDQNGLILGYKIL-FRAKDLDPE-----------PRSHIVRGNHTQ 1336

  Fly  1569 ------LQPSTLYQLRMEAHNVAGISQAEFNFV-TLTKDGDPPPPEIMHRGRSGQTTVIFANINL 1626
                  |:...||:|::.|....|........: ..|||..|.||                 :.|
Human  1337 SALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPP-----------------VRL 1384

  Fly  1627 LIPTIAAVS------------GMFCTIIMIIVCYRHMLKNAPPLAEQSQIQKESLENRANSEAAQ 1679
            :.|.:...|            |:   |:...:.||        ||..|.....::|         
Human  1385 VFPEVRLTSVRIVWQPPEEPNGI---ILGYQIAYR--------LASSSPHTFTTVE--------- 1429

  Fly  1680 RERYYATIHKVSMQNNDKIPETSEDISPYAT--FQLSEAGGNMSQPHHGGPANTLLHSFMYHERA 1742
               ..||:.:.          |:.|::|.:.  |:||.    .::...|.|....:.:....|| 
Human  1430 ---VGATVRQF----------TATDLAPESAYIFRLSA----KTRQGWGEPLEATVITTEKRER- 1476

  Fly  1743 LAEGCSSPP-----PAASKNRRRHSRKTEPESEESESDQDQLTSSRTESSNQHEGKIKHSIIYHG 1802
                 .:||     |.|....|....:..|.|:  .:...:..:.:.....:.|.:...|.|.|.
Human  1477 -----PAPPRELLVPQAEVTARSLRLQWVPGSD--GASPIRYFTMQVRELPRGEWQTYSSSISHE 1534

  Fly  1803 AQSSTSSDLSPMSEQKSLPRRGRSRYHHQQYQFSTNTTPRHHNSNKMNNNTTSNTNTTAT----- 1862
            |.:.....|.|.:..|.                      |...:|.:.::..|:.....|     
Human  1535 ATACVVDRLRPFTSYKL----------------------RLKATNDIGDSDFSSETEAVTTLQDV 1577

  Fly  1863 ------NTTATPSTSSNSNKIL----SPRGGNLKSISSTFKSQDSIQCHIPTLVKSPSISTQQQK 1917
                  :.:|||.|:|:   :|    .||..:|..:...::      .:...|.......|:.:.
Human  1578 PGEPPGSVSATPHTTSS---VLIQWQPPRDESLNGLLQGYR------IYYRELEYEAGSGTEAKT 1633

  Fly  1918 QFHKQQLQNSSTNNSQHSSSNPNSSSLKQQQPLLITPKLHQLEANGQELLGLDGIGNSP------ 1976
            .  |..:...:...:|.|....||||......|....|..:.|.   .:...:.||.||      
Human  1634 L--KNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEV---IMTAYNIIGESPASAPVE 1693

  Fly  1977 ------LVACMPPSSQFRPIPHKSIMPAHE--PPHHHNHSQQSH-----PHQQQQQQQHPGTLLN 2028
                  ..|..|.:.|..|:....:....:  ||...|.:.|.:     ....|.:.:....|..
Human  1694 VFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFL 1758

  Fly  2029 PSTA------------MLS-SKFFTAPTLPKXDTANGGSEYVGGAMEAMDGFGYDSGEISCTYMD 2080
            |...            ::| |.|..|...|| |...|.:........:...|    .||:.|   
Human  1759 PEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAF----SEITST--- 1816

  Fly  2081 PIDQTXDLAYGE 2092
                | ::::||
Human  1817 ----TLNVSWGE 1824

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845
Ig 138..>203 CDD:299845
I-set 238..327 CDD:254352 16/70 (23%)
Ig 247..327 CDD:299845 16/70 (23%)
I-set 332..418 CDD:254352 23/88 (26%)
IGc2 344..407 CDD:197706 17/65 (26%)
IG_like 432..517 CDD:214653 20/91 (22%)
IGc2 436..507 CDD:197706 18/77 (23%)
I-set 521..610 CDD:254352 26/101 (26%)
IGc2 533..597 CDD:197706 20/68 (29%)
Ig 630..699 CDD:143165 17/68 (25%)
IG_like 714..802 CDD:214653 29/92 (32%)
Ig 725..802 CDD:299845 25/81 (31%)
Ig 823..894 CDD:143165 18/72 (25%)
FN3 906..1006 CDD:238020 29/105 (28%)
FN3 1013..1111 CDD:238020 24/104 (23%)
FN3 1119..1209 CDD:238020 34/99 (34%)
FN3 1219..1313 CDD:238020 34/105 (32%)
Ig 1336..1402 CDD:143165 13/74 (18%)
FN3 1409..1498 CDD:238020 25/100 (25%)
FN3 1515..1588 CDD:238020 24/84 (29%)
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73 14/41 (34%)
I-set 104..188 CDD:254352 24/97 (25%)
Ig 122..176 CDD:143165 15/57 (26%)
Ig 219..265 CDD:299845 13/53 (25%)
IGc2 312..364 CDD:197706 16/56 (29%)
I-set 386..475 CDD:254352 19/91 (21%)
Ig 404..472 CDD:143165 17/70 (24%)
I-set 480..570 CDD:254352 32/106 (30%)
Ig 494..570 CDD:299845 27/92 (29%)
I-set 575..664 CDD:254352 25/96 (26%)
Ig 580..664 CDD:299845 24/91 (26%)
FN3 668..759 CDD:238020 28/99 (28%)
fn3 771..857 CDD:278470 23/96 (24%)
FN3 872..967 CDD:238020 35/104 (34%)
FN3 972..1054 CDD:238020 29/86 (34%)
FN3 1070..1166 CDD:238020 18/109 (17%)
FN3 1176..1271 CDD:238020 24/97 (25%)
fn3 1279..1365 CDD:278470 26/97 (27%)
FN3 1378..1471 CDD:238020 24/146 (16%)
FN3 1477..1572 CDD:238020 18/118 (15%)
FN3 1580..1694 CDD:238020 25/127 (20%)
FN3 1704..1797 CDD:238020 18/92 (20%)
FN3 1802..1883 CDD:238020 7/34 (21%)
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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