DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam2 and zig-2

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_510069.1	Gene:	zig-2 / 192087	WormBaseID:	WBGene00006979	Length:	238	Species:	Caenorhabditis elegans

Alignment Length:	214	Identity:	55/214 - (25%)
Similarity:	87/214 - (40%)	Gaps:	29/214 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 DAPPVLLYSFI--EQTLQPGPAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFMI-------GQYI 475
            |:.|:|.::..  :..:..|....|.|.|.|.|.|.|.|.|:|..:.......:       |:.:
Worm    28 DSQPLLKFTRTPNDSNVTFGEKFVLSCGANGAPLPSIYWELNGMRIQGEETSNVYENILNDGKQV 92

  Fly   476 TVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAAR-----------LNIYGLPYIRL-IPK 528
            :....|.||..|......:.|.|.||.:|...:::|.|:           ||..|.|:|.: :..
Worm    93 SNAAMVSSHYRIPCATARNSGAYKCIIDNGLTKLEHVAKVFVGGNKTNCALNDNGAPFISMTVDF 157

  Fly   529 VTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDD-IRQRVQPDGSLTISPVQKNSDSGVYTCWA 592
            ...:|...:.|.|  ......|..|.:|.:.|.:| .|.::.|.|.|.|..:.. ||.|.|.|.|
Worm   158 RLEISNNAVALSC--RSETATEWSWHKGEQLLTNDGERYQMFPSGDLIIRNISW-SDMGEYNCTA 219

  Fly   593 RNKQGHSARRSGEVTVIVP 611
            ||..|.:.    .:|.:.|
Worm   220 RNHFGETT----AITFLYP 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653	24/102 (24%)
		IGc2	436..507	CDD:197706	21/77 (27%)
		I-set	521..610	CDD:254352	25/90 (28%)
		IGc2	533..597	CDD:197706	21/64 (33%)
		Ig	630..699	CDD:143165
		IG_like	714..802	CDD:214653
		Ig	725..802	CDD:299845
		Ig	823..894	CDD:143165
		FN3	906..1006	CDD:238020
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
zig-2	NP_510069.1	I-set	34..134	CDD:254352	23/99 (23%)
		Ig	34..121	CDD:299845	20/86 (23%)
		Ig	<179..232	CDD:299845	19/57 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810