DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and igcm-2

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001362087.1	Gene:	igcm-2 / 180913	WormBaseID:	WBGene00020130	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	718	Identity:	165/718 - (22%)
Similarity:	261/718 - (36%)	Gaps:	205/718 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 GPAVSLKCSAA--------------------------GNPTPQISWTL--DGFPLPSNGRFMIGQ 473
            |..::|.||.:                          |:.||.:...|  |||         :|
Worm    28 GAPITLPCSISLFNEESFSLDWRKDGQLILSAFGQEQGHVTPTLQGRLARDGF---------LG- 82

  Fly   474 YITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQH-----AARLNIYGLPYIRLIPKVTAV- 532
             ||:|.          |...|.|.|.||....:.:...     :|:| :..:|.:.:.|...|:
Worm    83 -ITIHS----------VTDGDAGVYQCIVTKFSKQPTRPEKGLSAKL-VVNVPPVIISPSKNAII 135

  Fly   533 ---SGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARN 594
               .|..|..:|...|.|..||.|.|.        .|.:.....||:|.::: .|.|:|||.|.|
Worm   136 HKKVGADLIFECKAEGAPSPEITWSRN--------EQIISTSPVLTLSNLEE-GDKGLYTCLAVN 191

  Fly   595 KQGHSAR----RSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPID 655
            .:|:|..    |..:.|::   .|.|....:::   |......|........::.:|..:.:||.
Worm   192 IEGNSTSSIDVRFTKATIL---DLIPLNKTVIE---GSNVFWHCHANAQATAISYSWLFEKKPIK 250

  Fly   656 PTQ---HMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQALL-VNVPPRWIVEPVD 716
            .|.   ..:::..|     |.::::....:|.|:|..:|||.|..:|.|.| |..||    ||:.
Worm   251 TTSLGLRSNIRSGD-----LSLQDVRKSDSGWYTCEAKNSAGETTSSTAYLHVFYPP----EPLS 306

  Fly   717 AN-----VERNRHIMLHCQAQGVPTP-SIVWKKATGSKSGEYEEVRERPFTKLLGNGSLLLQHVK 775
            ::     |...|:..:.|.....||| |..|     ||:|.|...:        .:..:::.:.|
Worm   307 SHQPVQTVASGRNTTVSCDVIANPTPTSYTW-----SKNGHYLPTQ--------ASSHIIISYAK 358

  Fly   776 EDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRS-VMVKKGDTALLQCAVSGDKPINIV- 838
            ....|.|.|||:|..|.|......|.|...|.|:....| :.|:.||...:.|...|| |:.||
Worm   359 PGDGGIYGCQADNIAGKGSIVETHLIVAEPPVFTVAPPSEIKVRLGDQVSIPCQGFGD-PMPIVY 422

  Fly   839 WMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQ 903
            |:|. |..:|.||                  |..:.|:..|.|.|.|..:|........|.|.|:
Worm   423 WIRD-KKRINQST------------------LTFKKVEHLDHGAYECVVANSVETISTRVMLLVE 468

  Fly   904 -EPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQQIEVKDP 967
             ..|...|.::...::|.|:.|.|.|...|..|.|  .....:.|.:|       ||..|:..
Worm   469 ITKPQMASSIKFTCLNSSSMRISWTPGYNGGFDQT--FAVHAQNDVTL-------QWTSIKTS-- 522

  Fly   968 PHFN-AMIENLKPATRYAF---RVIAEGS-------------------------------AGRSA 997
              .| .::::|:|...|..   .|.|:||                               |...|
Worm   523 --LNETILDHLEPFVSYRVSIESVNAKGSTNSTTYNRRSCTSLHAPDKLYFCGYNELCWTAAEGA 585

  Fly   998 PSQELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPELRHGDIQGYNVGYKLSSSGNTAYN 1062
            .|..:..||||        |.:.:||:  |:|.::              |.:|..:..:..|.:.
Worm   586 SSYRIESRTEP--------SKNFQPLA--EVLETY--------------YRLGKDVDETKQTIFR 626

  Fly  1063 FTS 1065
            ..|
Worm   627 VRS 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653	23/112 (21%)
		IGc2	436..507	CDD:197706	21/97 (22%)
		I-set	521..610	CDD:254352	27/96 (28%)
		IGc2	533..597	CDD:197706	20/63 (32%)
		Ig	630..699	CDD:143165	14/71 (20%)
		IG_like	714..802	CDD:214653	23/93 (25%)
		Ig	725..802	CDD:299845	20/77 (26%)
		Ig	823..894	CDD:143165	19/71 (27%)
		FN3	906..1006	CDD:238020	26/134 (19%)
		FN3	1013..1111	CDD:238020	9/53 (17%)
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
igcm-2	NP_001362087.1	IG_like	23..101	CDD:214653	21/93 (23%)
		Ig	124..200	CDD:386229	24/84 (29%)
		IG_like	214..298	CDD:214653	19/91 (21%)
		Ig_3	309..371	CDD:372822	18/74 (24%)
		Ig	389..467	CDD:386229	27/97 (28%)
		FN3	476..548	CDD:238020	20/84 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810