DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and Ncam2

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus

Alignment Length:	898	Identity:	230/898 - (25%)
Similarity:	360/898 - (40%)	Gaps:	145/898 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 GDAPPVLLYSFIEQTLQPGPAVSLKCSAAGNPTPQISW-TLDGFPLPSNGRFMIGQYITVHGDVI 482
            |.|...:..|..:..|..|.:....|:|.|.| ..|.| ...|..:.|..|.|:.:     ..|.
Mouse    17 GQALLQVTISLSKVELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVMLQK-----EGVR 75

  Fly   483 SHVNISHVMVEDGGEYACIAENRAGRVQHA-ARLNIY-GLPYIRLIPKVTAVSGETLNLKCPVAG 545
            |.:.|.:..:||.|.|.|.|.:..|:.|.| ..|.|| .|.:..::.......||...:.|.|:.
Mouse    76 SRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSS 140

  Fly   546 YPIEEIHWERGGRE---LPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWAR-NKQGHSARRSGEV 606
            .|...:.|.....|   :||: |..|..:.:|.|..:.| ||.|:|.|..| ..:|....|...|
Mouse   141 SPAPAVSWLYHNEEVTTIPDN-RFAVLANNNLQILNINK-SDEGIYRCEGRVEARGEIDFRDIIV 203

  Fly   607 TVIVPPK-LSPFQTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNS 670
            .|.|||. :.|.::.......|:..:|||. ..|....||:|.::|:.|:..:...:|   ..|:
Mouse   204 IVNVPPAIMMPQKSFNATAERGEEMTLTCK-ASGSPDPTISWFRNGKLIEENEKYILK---GSNT 264

  Fly   671 ILVIENLGSDHTGNYSCVVRNSAAEVENSQALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVP 735
            .|.:.|:.:...|:|.|...|.|.|.:....|.|.|.|. |::..:.....|.|:.|.|:|:|.|
Mouse   265 ELTVRNIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPH-ILQLKNETTSENGHVTLVCEAEGEP 328

  Fly   736 TPSIVWKKA-------TGSKSGEYE-EVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGT 792
            .|.|.||:|       .|.||.:.. ||:.:.     |..||.::.||....|.|.|:|.:.||
Mouse   329 VPEITWKRAIDGVMFSEGDKSPDGRIEVKGQH-----GRSSLHIRDVKLSDSGRYDCEAASRIG- 387

  Fly   793 GIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPINIVWMRS-----GKNTLNPSTN 852
            |..:.:.|.:..:|.|.|........:|:...:.|.|:.:.|.:|.|.|.     .|||.:..|:
Mouse   388 GHQRSMHLDIEYAPKFVSNQTMYYSWEGNPINISCDVTANPPASIHWRREKLLLPAKNTTHLKTH 452

  Fly   853 YKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAMI 917
               ||       |....|:|......|.|.|.|.|:|..|...|...|::.:.|..|..::...:
Mouse   453 ---SV-------GRKMILEIAPTSDNDFGRYNCTATNRIGTRFQEYILELADVPSSPHGVKIIEL 507

  Fly   918 SSRSVNIKW-QPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQQIEVKDPPHFNAMIENLKPAT 981
            |..:..|.: :|::.|...:..|.|:.:|        :..:.|:.:. ........::.:|:|.|
Mouse   508 SQTTAKISFNKPESHGGVPIHHYQVDVKE--------VASETWKIVR-SHGVQTMVVLSSLEPNT 563

  Fly   982 RYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARPLSSTELLISWV------APLPELR 1040
            .|..||.|....|:...|:..|.:|.|.|...|| |:..:|.|.....||..      ||:.|
Mouse   564 TYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPP-SIHGQPSSGKSFKISITKQDDGGAPILE-- 625

  Fly  1041 HGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVGPGPLSE 1105
                  |.|.|: |......:....|.|:.|    .::|..|.....|.|.:.|.|::|   .||
Mouse   626 ------YIVKYR-SKDKEDQWLEKKVQGNKD----HIILEHLQWTMGYEVQITAANRLG---YSE 676

  Fly  1106 PTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHT--NGLLQG-------YKLIFEPIID 1161
            ||..:.     |.||                 :|..|..|  |||..|       ..|:...::.
Mouse   677 PTVYEF-----SMPP-----------------KPNIIKDTLFNGLGLGAIIGLGVAALLLILVVT 719

  Fly  1162 DIQPSKDEVESRKTTALTMVLT----GLRKYTNYSIQVLAHTR---MGDGVVSKPLFCHSEEDVP 1219
            |:     .....:...|.|.:|    |.:..::...:.|...:   :.||         |:|.:.
Mouse   720 DV-----SCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDG---------SKEPIV 770

  Fly  1220 E-APADIKVVSSSSQSLYISWLPPNEPNGV--ITK-YSLYTRVVNGREELNNE 1268
            | ...|.::.:....|      |.||||..  :|: ..|..:..||:|.||.|
Mouse   771 EMRTEDERITNHEDGS------PVNEPNETTPLTEPEKLPLKEENGKEVLNAE 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653	25/86 (29%)
		IGc2	436..507	CDD:197706	20/71 (28%)
		I-set	521..610	CDD:254352	24/92 (26%)
		IGc2	533..597	CDD:197706	20/67 (30%)
		Ig	630..699	CDD:143165	19/68 (28%)
		IG_like	714..802	CDD:214653	30/95 (32%)
		Ig	725..802	CDD:299845	28/84 (33%)
		Ig	823..894	CDD:143165	22/75 (29%)
		FN3	906..1006	CDD:238020	20/100 (20%)
		FN3	1013..1111	CDD:238020	28/103 (27%)
		FN3	1119..1209	CDD:238020	18/105 (17%)
		FN3	1219..1313	CDD:238020	16/54 (30%)
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274	26/96 (27%)
		I-set	22..111	CDD:254352	26/94 (28%)
		I-set	117..193	CDD:254352	20/77 (26%)
		IGc2	128..189	CDD:197706	19/62 (31%)
		Ig	208..301	CDD:299845	25/96 (26%)
		I-set	215..298	CDD:254352	21/86 (24%)
		Ig	300..397	CDD:299845	33/103 (32%)
		IG_like	308..395	CDD:214653	29/92 (32%)
		IG_like	413..491	CDD:214653	24/87 (28%)
		IGc2	414..482	CDD:197706	22/77 (29%)
		FN3	496..588	CDD:238020	20/100 (20%)
		fn3	594..678	CDD:278470	26/100 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810		13/60 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810