DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and Ncam1

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	XP_006510118.1	Gene:	Ncam1 / 17967	MGIID:	97281	Length:	1162	Species:	Mus musculus

Alignment Length:	1507	Identity:	305/1507 - (20%)
Similarity:	481/1507 - (31%)	Gaps:	526/1507 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 LTVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYK-DGRQL-PSSGRV------ 381
            |..|..:||:|.|:...:.:|.:..|.|.|..:...   ::|.|:. :|.:| |:..|:
Mouse    14 LGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKD---KDISWFSPNGEKLSPNQQRISVVWND 75

  Fly   382 --EDTLVVPRVSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKC 444
              ..||.:...:.::.|:|:|||...:|...:||..::                      :..|.
Mouse    76 DDSSTLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVK----------------------IFQKL 118

  Fly   445 SAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRV 509
            .....||||              .|..|:...:..||:|
Mouse   119 MFKNAPTPQ--------------EFKEGEDAVIVCDVVS-------------------------- 143

  Fly   510 QHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEIHWERGGRE--LPDDIRQRVQPDG 572
                     .||                           ..|.|:..||:  |..|:|..|..:.
Mouse   144 ---------SLP---------------------------PTIIWKHKGRDVILKKDVRFIVLSNN 172

  Fly   573 SLTISPVQKNSDSGVYTCWAR-NKQGHSARRSGEVTVIVPPKLSPFQTNI-LQLNMGDRASLTCS 635
            .|.|..::| :|.|.|.|..| ..:|....:..:|.|.|||.:...|:.: ...|:|...:|.|.
Mouse   173 YLQIRGIKK-TDEGTYRCEGRILARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCD 236

  Fly   636 VVKGDLPLTINWRKDGRPIDPTQHMSVKQV-DQYNSILVIENLGSDHTGNYSCVVRNSAAEVENS 699
             ..|....|::|.|||.||:..:....|.: ...:|.|.|.|:..:....|.|:..|.|.|.:.|
Mouse   237 -ADGFPEPTMSWTKDGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDAS 300

  Fly   700 QALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTKLL 764
            ..|.|...|:.........:|....:.|.|:|.|.|.|||.|:.:|.:.|.|.:....||..:..
Mouse   301 IHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQET 365

  Fly   765 GNG-----------SLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVK 818
            .:|           ||.|:.::....|.|:|.|:|.||.. .:.:.|:|..:|...... :|...
Mouse   366 LDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQGPV-AVYTW 428

  Fly   819 KGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPY 883
            :|:...:.|.|.......|.|.|.|:  |.||:||. ::|...||.  ::.|::......|.|.|
Mouse   429 EGNQVNITCEVFAYPSATISWFRDGQ--LLPSSNYS-NIKIYNTPS--ASYLEVTPDSENDFGNY 488

  Fly   884 FCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAMISSRSVNIKW-QPKTLGTGDVTKYIVEFREAD 947
            .|.|.|..|.:.....|...:.|..||:......|| :..::: :|:..|...:.||..|::
Mouse   489 NCTAVNRIGQESLEFILVQADTPSSPSIDRVEPYSS-TAQVQFDEPEATGGVPILKYKAEWK--- 549

  Fly   948 HSLPPALFVDQWQQIEVKDPPHFN------------AMIENLKPATRYAFRVIAEGSAGRSAPSQ 1000
                 :|..:.|         ||.            ..|..|||.|||:.|:.|....|....|.
Mouse   550 -----SLGEESW---------HFKWYDAKEANMEGIVTIMGLKPETRYSVRLAALNGKGLGEISA 600

  Fly  1001 ELIVRTEPQRPAGPPLSLSARPLSSTELL------ISW---VAPLPELRHGDIQGYNVGYKLSSS 1056
            ....:|:|.. :.|||:    |.:|:.|:      .:|   |.|..:|..|:.....:..::...
Mouse   601 ATEFKTQPVH-SPPPLA----PANSSTLVPLSPRATTWPLPVLPTTDLSKGEPSAPKLEGQMGED 660

  Fly  1057 GNTAYNFTSVSGDGDG--------------------------GNGELLLSGLAKFARYTVVVQAF 1095
            || :.....:..|..|                          |:..::|..|...|.|.|.|.|.
Mouse   661 GN-SIKVNLIKQDDGGSPIRHYLVKYRAKLASEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAE 724

  Fly  1096 NQVGPGPL--------SEPTAAQTMEDVPSRPPE------------------------DV----- 1123
            ||.|....        ::|||      :|:....                        |:
Mouse   725 NQQGKSKAAHFVFRTSAQPTA------IPANGSPTAGLSTGAIVGILIVIFVLLLVVMDITCYFL 783

  Fly  1124 -RCAALSSQSLQVSWQPPPIYHTNGLLQGYKLIF------EPII-----DDIQPSKD---EVESR 1173
             :|..|...::.:..:..|......:.:| |..|      |||:     ::..|:.|   ..|..
Mouse   784 NKCGLLMCIAVNLCGKAGPGAKGKDMEEG-KAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPN 847

  Fly  1174 KTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPEAPAD-----------IKV 1227
            :||.||                                      .||.|||           :..
Mouse   848 ETTPLT--------------------------------------EPELPADTTATVEDMLPSVTT 874

  Fly  1228 VSSSSQSLYISW-LPPNEPNGVITKYSLYTRVVNGREELNNEKRSLPSQQAYYEAKGLHPHMEYQ 1291
            |:::|.::..:: ...|.|....|   ..|..:........:..|:|:.|| ..:||
Mouse   875 VTTNSDTITETFATAQNSPTSETT---TLTSSIAPPATTVPDSNSVPAGQA-TPSKG-------- 927

  Fly  1292 FWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTLPCTAVGKPKREWFKSDVA 1356
              ||||:      ||..|:                |.|.|   .|.|..|....|......|.|.
Mouse   928 --VTASS------SSPASA----------------PKVAP---LVDLSDTPTSAPSASNLSSTVL 965

  Fly  1357 LRQGGLHNSQLLDSGDLIISSLQLADGGNYSCQVDNGIGTDRLTHTLIVQVPP---TAPVLYVTS 1418
            ..||.            ::|....|..|..|                  :.||   .:|....|.
Mouse   966 ANQGA------------VLSPSTPASAGETS------------------KAPPASKASPAPTPTP 1000

  Fly  1419 ATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQLSRHASSHELKGLMCGSTYQIHLSAQN 1483
            |.::|             |:...      |...||..|..:.|.|.:
Mouse  1001 AGAAS-------------PLAAV------AAPATDAPQAKQEAPSTK------------------ 1028

  Fly  1484 KVGTSPTSTILHVRTQGQSPGHPASTALLAPNSTSLLVRLHSWPDNGCPLLYFVLQYRAVTDDPD 1548
              |..|..|         .||                                     .|.:.|:
Mouse  1029 --GPDPEPT---------QPG-------------------------------------TVKNPPE 1045

  Fly  1549 AEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHNVAGISQAEFNFVT----LTKD-----GDPP 1604
            |.....|    |:.:....|  ||....|:|:          |.||.|    |.||     |.|.
Mouse  1046 AATAPAS----PKSKAATTN--PSQGEDLKMD----------EGNFKTPDIDLAKDVFAALGSPA 1094

  Fly  1605 PPEIMHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYRHMLKNAPPLAEQSQIQKESL 1669
            |.    .|.|||.:.       |.|:.|..:                :..||...|:..::.:|.
Mouse  1095 PA----TGASGQASE-------LAPSTADSA----------------VPPAPAKTEKGPVETKSE 1132

  Fly  1670 ENRANSEAAQRE 1681
            ...:.::.|..|
Mouse  1133 PPESEAKPAPTE 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352	1/1 (100%)
		Ig	247..327	CDD:299845	1/1 (100%)
		I-set	332..418	CDD:254352	24/95 (25%)
		IGc2	344..407	CDD:197706	17/72 (24%)
		IG_like	432..517	CDD:214653	10/84 (12%)
		IGc2	436..507	CDD:197706	10/70 (14%)
		I-set	521..610	CDD:254352	20/91 (22%)
		IGc2	533..597	CDD:197706	16/66 (24%)
		Ig	630..699	CDD:143165	20/69 (29%)
		IG_like	714..802	CDD:214653	27/98 (28%)
		Ig	725..802	CDD:299845	26/87 (30%)
		Ig	823..894	CDD:143165	22/70 (31%)
		FN3	906..1006	CDD:238020	25/112 (22%)
		FN3	1013..1111	CDD:238020	29/140 (21%)
		FN3	1119..1209	CDD:238020	17/133 (13%)
		FN3	1219..1313	CDD:238020	24/105 (23%)
		Ig	1336..1402	CDD:143165	12/65 (18%)
		FN3	1409..1498	CDD:238020	15/91 (16%)
		FN3	1515..1588	CDD:238020	10/72 (14%)
Ncam1	XP_006510118.1	Ig1_NCAM-1	20..115	CDD:143273	24/119 (20%)
		IG	124..190	CDD:214652	25/142 (18%)
		Ig3_NCAM-1_like	211..308	CDD:143207	28/97 (29%)
		Ig_NCAM-1	307..413	CDD:143277	28/106 (26%)
		Ig_3	417..494	CDD:372822	23/82 (28%)
		FN3	509..606	CDD:238020	25/114 (22%)
		fn3	649..731	CDD:365830	15/82 (18%)
		PHA03247	<905..1140	CDD:223021	77/428 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900