DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and lad-2

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001023496.1	Gene:	lad-2 / 177078	WormBaseID:	WBGene00002243	Length:	1187	Species:	Caenorhabditis elegans

Alignment Length:	1136	Identity:	285/1136 - (25%)
Similarity:	438/1136 - (38%)	Gaps:	251/1136 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 RCLVTSN---------GSP--VGMQNILWYKDGRQLPSSGRVEDTLVVPRVSRENRGMYQCVVRR 404
            ||....|         |.|  :..:::||.|:.:    ||    ::|..:....::|.|||....
Worm    52 RCEADENTDRYSWLKDGEPFVIDSEDVLWEKESQ----SG----SIVFTKPHASHQGYYQCFASN 108

  Fly   405 PEGDTFQATAELQLGDAPPVLLYSFIEQ-----TLQPGPAVSLKCS-AAGNPTPQISW---TLDG 460
            ..|........|:||.     |..|.::     .::.|.:::|.|: ..|.|.|:|.|   :||.
Worm   109 IFGTALSNKMHLRLGS-----LEHFPKRDVKLLRVKEGESLTLNCTPPRGTPDPKIVWLYRSLDD 168

  Fly   461 FPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGE---YACIA-------ENRAG-RVQHAAR 514
            ..:....|   .::|||..:  .|::.|.|.:.||..   |.|.|       |.|:| |:|
Worm   169 SSVIETIR---SRHITVDNE--GHLHFSSVELSDGKATLVYECAATSPVLRGEYRSGDRIQ---- 224

  Fly   515 LNI-------YGLPYIRLIP-KVTAVSGETLNLKCPVAGYPIEEIHWERGGRELP----DDIRQR 567
            |:|       :.:..:.:.| :||..:|..|.|:|...|.|:..|.|.:...|||    .|:...
Worm   225 LDIEPSQDKSHPVKKMSVSPSEVTVRAGGQLKLQCIFGGRPLPTIFWSKIDGELPKSRIKDLTSH 289

  Fly   568 VQPDG-SLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKLSPF----QTNILQLNMG 627
            ....| ||.:..|..: |:|.|.|..|    |...     ||.|....:||    ....:.|...
Worm   290 ESDFGRSLIVENVHPD-DAGAYECRGR----HLVH-----TVNVRVMAAPFWEFDPPRDISLPEE 344

  Fly   628 DRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSD-HTGNYSC---- 687
            ....|.|.......|: |.|..:|:.:......|.:.:..:..||.:.||..| .||.|.|
Worm   345 STGELECLAGGQPTPI-ITWSMNGKFLHELAEDSRRVLLDHGRILRVRNLNHDLDTGVYQCNASN 408

  Fly   688 ----VVRNSAAEVENSQALLVNVPP--RWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATG 746
                |..|:...| .:.|....:|.  .|       .|..:..::|.|.....|...:.|..|.
Worm   409 PLGYVFANAFVHV-RAHAPFFRMPAARHW-------KVVLHSTVVLDCDVDAAPEAMVRWVDAD- 464

  Fly   747 SKSGEYEEVRERPF------TKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVI-QLKVNS 804
                      :||.      .||..|.:.::..|....||.|.|..:|..  ||.:.. :|:|..
Worm   465 ----------DRPLQVVEGKNKLFPNHTFMVYDVNSADEGLYYCNVSNKY--GINRATNRLQVFK 517

  Fly   805 SPYF--SSTSRSVMVKKGDTALLQCAVSGDK--PINIVWMRSGKNTLNPSTNYKISVKQEATPDG 865
            ..||  ..|.:.::::.|:||.:.|....|.  ||...|..:|| .|..|..|:|      .||
Worm   518 PTYFVRIPTPKRLILEAGETAEVFCEAVADPRLPIRYQWTINGK-VLTESQYYEI------LPD- 574

  Fly   866 VSAELQIRTVDATDSGPYFCRASNLYGNDQQL--VQLQVQEPPLPPSVLEAAMISSRSVNIKWQP 928
               .|:.|:|....||...|.|  :...|.:|  :||.|::.|..| |:|.|..|.|...:||..
Worm   575 ---RLRFRSVRGRHSGIIDCAA--ITDVDVKLASMQLIVKDVPAHP-VVETAHCSERKATVKWVA 633

  Fly   929 KTLGTGDVTKYIVEFREADHSLPPALFVD----QWQQI--EVK-DPPHFNAMIENLKPATRYAFR 986
            .:.....:.|||||           :|.|    :|:.|  ||. :...|...| .|.|...|.||
Worm   634 ASDHGDSIKKYIVE-----------MFTDFKKNEWEVINEEVNVNKETFEVDI-TLTPWVNYTFR 686

  Fly   987 VIAEGSAGRS------APSQE-LIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPL-------P 1037
            |:|..|.|||      .|.:: |..:|.|..|...|..:.........|:||| .||       |
Worm   687 VVAVNSHGRSDMKIDGQPKEDWLTCQTRPSFPYTNPTGVKGEGTEPDNLVISW-KPLDRYYWNAP 750

  Fly  1038 ELRHGDIQGYNVGYKLSS--SGNTAY-------NFTSVSGDGDGGNGELLLSGLAKFARYTVVVQ 1093
            .::      |.|.|||..  .|.|.:       |||             ::.....|.:|.:.||
Worm   751 NMQ------YLVRYKLDEPIHGWTEFLVEDSLANFT-------------IIRDQPTFRKYLIQVQ 796

  Fly  1094 AFNQVGPGPLSEPTA--AQTMEDVPSRPPEDVRC-AALSSQSLQVSWQPPPIYHTNGLLQGYKLI 1155
            :.|.|||. :.||..  ..:.||||...|.|... ..::..::..:|.|......||...||::.
Worm   797 SVNSVGPS-IVEPEIHHGWSGEDVPDEAPRDFHIDTQINFTTINFTWNPVDANTVNGHFVGYEIE 860

  Fly  1156 FEPIIDDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPE 1220
            :....:.|:....::.:..|   ..|:......||||    ||.|..:..:......:....:||
Worm   861 YWKAENTIRKYSIKIPANST---YKVINSFHAVTNYS----AHIRTRNKRLRSAPSDYVSFAMPE 918

  Fly  1221 APA----DIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREELNNEKRSLPSQQAYYEA 1281
            .|.    :::|.|..|.::.:.|..|.:|||.|..|.:..:    .|:...|:..:..:|.:|..
Worm   919 GPPGKVHNLRVYSVGSTAILLQWDAPLQPNGRIRGYFISFQ----NEKNETEETYVIHRQKHYLH 979

  Fly  1282 KGLHPHMEYQFWVTASTRVGEGKSSRVSSQITTNRI---PARI----------ISFGGPVVRPWR 1333
            :...|...|:..|.|.||.|||       .:|...:   ||||          ||....||. |:
Worm   980 EKSEPDTGYKVSVWAETRAGEG-------PVTLRPVRTWPARIPDAPIFRVKNISLDSFVVE-WQ 1036

  Fly  1334 ----STVTLPCTA-----VGKPKREWFKSDV 1355
                |...:|..|     ..:..:.||:|::
Worm  1037 PNNHSVWKMPGAAFFVNYTAESSKTWFQSEI 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352	17/77 (22%)
		IGc2	344..407	CDD:197706	15/66 (23%)
		IG_like	432..517	CDD:214653	28/104 (27%)
		IGc2	436..507	CDD:197706	24/84 (29%)
		I-set	521..610	CDD:254352	27/94 (29%)
		IGc2	533..597	CDD:197706	21/68 (31%)
		Ig	630..699	CDD:143165	19/77 (25%)
		IG_like	714..802	CDD:214653	20/94 (21%)
		Ig	725..802	CDD:299845	19/83 (23%)
		Ig	823..894	CDD:143165	21/72 (29%)
		FN3	906..1006	CDD:238020	35/113 (31%)
		FN3	1013..1111	CDD:238020	28/115 (24%)
		FN3	1119..1209	CDD:238020	18/90 (20%)
		FN3	1219..1313	CDD:238020	26/97 (27%)
		Ig	1336..1402	CDD:143165	5/25 (20%)
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
lad-2	NP_001023496.1	IG_like	48..116	CDD:214653	16/71 (23%)
		Ig	49..121	CDD:299845	16/76 (21%)
		Ig	124..214	CDD:299845	24/99 (24%)
		IG_like	244..325	CDD:214653	28/90 (31%)
		Ig	255..325	CDD:299845	24/79 (30%)
		I-set	335..421	CDD:254352	19/86 (22%)
		Ig4_L1-NrCAM_like	344..422	CDD:143179	19/79 (24%)
		IG_like	438..515	CDD:214653	20/89 (22%)
		Ig	443..516	CDD:299845	19/85 (22%)
		IG_like	527..608	CDD:214653	27/93 (29%)
		Ig	535..>593	CDD:299845	22/68 (32%)
		FN3	610..697	CDD:238020	32/99 (32%)
		FN3	721..804	CDD:238020	25/102 (25%)
		fn3	823..909	CDD:278470	18/92 (20%)
		FN3	921..1010	CDD:238020	24/99 (24%)
		FN3	1016..1108	CDD:238020	11/53 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910