DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and unc-89

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001020985.1	Gene:	unc-89 / 171990	WormBaseID:	WBGene00006820	Length:	8081	Species:	Caenorhabditis elegans

Alignment Length:	2210	Identity:	437/2210 - (19%)
Similarity:	748/2210 - (33%)	Gaps:	680/2210 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LDCSASGSPQPTVDWVHADGSAVTEIHGVRRVLRNGTLVLMPFAAAAYHQDVHNT---------- 105
            |.||..|||||     |.|..:.:|...|...:.:.:.:       |...|..||
Worm  3106 LSCSVKGSPQP-----HVDFYSFSETTKVETKITSSSRI-------AIEHDQTNTHWRMVISQIT 3158

  Fly   106 -----IYRCIASNSVGRIVSRDVQVRAVVAQAY---------------KVDVEVLSAARGC---- 146
                 .|:.||:||:|...|.......|.|..:               |::|:|..:|...
Worm  3159 KEDIVSYKAIATNSIGTATSTSKITTKVEAPVFEQGLKKTSVKEKEEIKMEVKVGGSAPDVEWFK 3223

  Fly   147 ------------------TAILRCVV------------------------------------PTF 157
                              |.:...||                                    |||
Worm  3224 DDKPVSEDGNHEMKKNPETGVFTLVVKQAATTDAGKYTAKASNPAGTAESSAEAEVTQSLEKPTF 3288

  Fly   158 VKELVR-------------VVSWVHEPAI--------------YIYPSLQGDGKFHLLPTGELLI 195
            |:|||.             .|..|.:|::              ::...::|.|.:.:......|
Worm  3289 VRELVTTEVKINETATLSVTVKGVPDPSVEWLKDGQPVQTDSSHVIAKVEGSGSYSITIKDARL- 3352

  Fly   196 HNLQESDESQSFRCRSMHRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQVSQDEGAVLLCV 260
                  ::|..:.||:.:     ....:.|.......:.::.|..||..:.::|.:.|...|...
Worm  3353 ------EDSGKYACRATN-----PAGEAKTEANFAVVKNLVPPEFVEKLSPLEVKEKESTTLSVK 3406

  Fly   261 AQGCPSPEYSWFTHNGAGPLPVLSGPRVRLLGPILAI--------EAVTGEDSGVYKCTAGNVGG 317
            ..|.|.|...||..:    .|: |...|.::....|:        :|..| |.|:|.|.|.|..|
Worm  3407 VVGTPEPSVEWFKDD----TPI-SIDNVHVIQKQTAVGSFSLTINDARQG-DVGIYSCRARNEAG 3465

  Fly   318 EASAELRLTVAT--PIQVEISPNV------LSVHMGGTAEFRCLVTSNGSPVGMQNILWYKDGRQ 374
            ||     ||.|.  .|:..|.|..      |.|....|.:.:  ||..|:||  .|:.|:||.:.
Worm  3466 EA-----LTTANFGIIRDSIPPEFTQKLRPLEVREQETLDLK--VTVIGTPV--PNVEWFKDDKP 3521

  Fly   375 L---------PSSGRVEDTLVVPRVSRENRGMYQCVVRRPEGDTFQATAELQLGD--APPVLLYS 428
            :         ...|....||.:.:...|:.|:|.|......|:. :.||.:.:.:  ..|:.:..
Worm  3522 INIDNSHIFAKDEGSGHHTLTIKQARGEDVGVYTCKATNEAGEA-KTTANMAVQEEIEAPLFVQG 3585

  Fly   429 FIEQTLQPGPAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMV- 492
            .....::.|....|.....|.|.|::.|..||.|:..:.:.:|.:    .|:     |.||.:|
Worm  3586 LKPYEVEQGKPAELVVRVEGKPEPEVKWFKDGVPIAIDNQHVIEK----KGE-----NGSHTLVI 3641

  Fly   493 -----EDGGEYACIAENRAGRVQHAARLNI--YGLP----------YIRLIPKVTAVSGETLNLK 540
                 .|.|:|.|.|.|:||:.:....|.|  |...          :|..:.:..||.|:|:.|:
Worm  3642 KDTNNADFGKYTCQATNKAGKDETVGELKIPKYSFEKQTAEEVKPLFIEPLKETFAVEGDTVVLE 3706

  Fly   541 CPVAGYPIEEIHWERGGRELPDDIRQRVQ----PDGSLTISPVQ--KNSDSGVYTCWARNKQG-- 597
            |.|......:|.:.:  .:.|.:|.|.:|    .||::.:: :|  |..|.|.|.|.|.|..|
Worm  3707 CKVNKESHPQIKFFK--NDQPVEIGQHMQLEVLEDGNIKLT-IQNAKKEDVGAYRCEAVNVAGKA 3768

  Fly   598 ----------------HSARRSGEVTVIVPPKLSPFQTNILQLNMGDRAS--------------- 631
                            |....||::     .::..|:|      :||.||
Worm  3769 NTNADLKIQFAAKVEEHVTDESGQL-----EEIGQFET------VGDTASSKTDTGRGAPEFVEL 3822

  Fly   632 -LTCSV-----------VKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGN 684
             .:|:|           |||:....|.|.|:|:.::.:..:..:..|.....|..:|:.....|.
Worm  3823 LRSCTVTEKQQAILKCKVKGEPRPKIKWTKEGKEVEMSARVRAEHKDDGTLTLTFDNVTQADAGE 3887

  Fly   685 YSCVVRNSAAEVENSQALLVNV---------PPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIV 740
            |.|...|..........::|.:         .|.::.....|.|......:|..:..|.|.||:.
Worm  3888 YRCEAENEYGSAWTEGPIIVTLEGAPKIDGEAPDFLQPVKPAVVTVGETAVLEGKISGKPKPSVK 3952

  Fly   741 WKKATGSKSGEYEEVRERPFTKLLGNGS--LLLQHVKEDREGFYLCQANNGIG---TGIGKVIQL 800
            |     .|:||..:..:|...:.|.:|:  |.:.:.|.|....|.|:|:|..|   :.:...::.
Worm  3953 W-----YKNGEELKPSDRVKIENLDDGTQRLTVTNAKLDDMDEYRCEASNEFGDVWSDVTLTVKE 4012

  Fly   801 KVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDG 865
            ....:|.|.....::.||:.:||..:|.|||.|| ::.|.:.|    .|....| .|..|:|.||
Worm  4013 PAQVAPGFFKELSAIQVKETETAKFECKVSGTKP-DVKWFKDG----TPLKEDK-RVHFESTDDG 4071

  Fly   866 VSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAMISSR---------- 920
             :..|.|......|.|.|....||..|         |....:|.:|:.:..:..:
Worm  4072 -TQRLVIEDSKTDDQGNYRIEVSNDAG---------VANSKVPLTVVPSETLKIKKGLTDVNVTQ 4126

  Fly   921 ------SVNIKWQPKTL----GTGDVTK----YIVEFREADHSLPPALFVDQWQQIEVKDPPHF- 970
                  ||.::.:|||:    ||..||.    .||:..|:::.|       :.:..|:.|...:
Worm  4127 GTKILLSVEVEGKPKTVKWYKGTETVTSSQTTKIVQVTESEYKL-------EIESAEMSDTGAYR 4184

  Fly   971 ------------NAMIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARPL 1023
                        :|.:...|.|.:.:.....:|.|.:|.|.             |.||.|... :
Worm  4185 VVLSTDSFSVESSATVTVTKAAEKISLPSFKKGLADQSVPK-------------GTPLVLEVE-I 4235

  Fly  1024 SSTELLISWVAPLPELRHGDIQGYNVGYKLSSSGNTAYNFT------------SVSGDGDGGNGE 1076
            ......:.|.....|::.|         |:...||..|..|            ||:...:.|..|
Worm  4236 EGKPKDVKWYKNGDEIKDG---------KVEDLGNGKYRLTIPDFQEKDVGEYSVTAANEAGEIE 4291

  Fly  1077 L-----------LLSGLAKFARYTVVVQ----AFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCA 1126
            .           ::|||..    |.|.|    .||....||:......:..:::|....:|   .
Worm  4292 SKAKVNVSAKPEIVSGLVP----TTVKQGETATFNVKVKGPVKGVKWYKNGKEIPDAKTKD---N 4349

  Fly  1127 ALSSQSLQVSWQPPPIYHTNGLLQ---GYKLIFEPIIDDIQPS-----------KDEVESRKTTA 1177
            ...|.||::         .|..::   .||::......|...|           ||:|:....:.
Worm  4350 GDGSYSLEI---------PNAQVEDAADYKVVVSNDAGDADSSAALTVKLADDGKDKVKPEIVSG 4405

  Fly  1178 LTMVLTGLRKYTNYSIQVLAHTRM------------------GDGVVSKPLFCHSEEDVPEA--- 1221
            |........:...::::|....:.                  |||..|.        ::|.|
Worm  4406 LIPTTVKQGETATFNVKVKGPVKQVKWYKNGKEIPNAKAKDNGDGSYSL--------EIPNAQLD 4462

  Fly  1222 -PADIKVVSS-------SSQSLYISWLPPNEPNGVITKYSLYTRVVNGRE-----ELN------- 1266
             .||.|||.|       ||.:|.:..     |...|.|......|..|::     |.|
Worm  4463 DTADYKVVVSNDAGDADSSAALTVKL-----PGIAIVKGLEDAEVPKGKKAVLQVETNKKPKEIK 4522

  Fly  1267 ---NEKRSLPSQQAYYEAKGLH-PHM-----------EYQFWVTASTRVGEGKSSRVSSQITTNR 1316
               |.|...||.:|...:.|.: |.:           ||:..:|     .|..::..||...|.:
Worm  4523 WYKNGKEITPSDKAQPGSDGDNKPQLVIPDAGDDDAAEYKVVLT-----DEDGNTADSSCALTVK 4582

  Fly  1317 IPAR-----------IISFGGPVVRPWRSTVTLPCTAVGKPKR-EWFKSDVALRQGGLHNSQLLD 1369
            :||:           ::|.|.|        :.|.....|.||. :|:|:...|........::..
Worm  4583 LPAKEPKIIKGLEDQVVSIGSP--------IKLEIETSGSPKTVKWYKNGKELPGAAAKTIKIQK 4639

  Fly  1370 SGD----LIISSLQLADGGNYSCQVDNGIGTDRLTHTLIVQVPPT--APV------------LYV 1416
            ..|    |.|.|..:.|.|:|..:|.|..|:...:..:.|:...|  .|:            ..|
Worm  4640 IDDNKYVLEIPSSVVEDTGDYKVEVANEAGSANSSGKITVEPKITFLKPLKDQSITEGENAEFSV 4704

  Fly  1417 TSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQLSRHASSHELKGLMCGSTYQIHLSA 1481
            .:.|...|:..:|.|    ..|...:.|......:|....:.::|...:      ..||:|.|
Worm  4705 ETNTKPRIVKWYKNG----QEIKPNSRFIIEQKTDTKYQLVIKNAVRDD------ADTYKIVL-- 4757

  Fly  1482 QNKVGTSPTSTILHVRTQGQSPGHPASTALLAPNSTSLLVRLHSWPDNGCPLLYFVLQYRAVTDD 1546
            :|..|.:.:|..|.|:..      .|....:.......:|.      .|..:::.|    .:..:
Worm  4758 ENTAGEAESSAQLTVKKA------KAGLCKIVKGLEDQVVA------KGAKMVFEV----KIQGE 4806

  Fly  1547 P-DAEWVLVSNALKPQRRIVINNLQPSTLYQL-------------RMEAHNVAGISQAEFNFVTL 1597
            | |..|:..:|.:......:|..:..:| |:|             .:|..|.:|.::::
Worm  4807 PEDVRWLRDANVISAGANAIIEKIDDTT-YRLIIPSADLKDAGEYTVEVINESGKAKSD------ 4864

  Fly  1598 TKDGDPPPPEIMHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYRHMLKNAPPLAEQS 1662
            .|......|||: ||..          |:.||  .....:|...:           :||  ..|.
Worm  4865 AKGEVDEKPEIV-RGLE----------NIEIP--EGDDDVFKVEV-----------SAP--VRQV 4903

  Fly  1663 QIQKESLENRANSEAAQR----ERYYATIHKVSMQNNDKIPETSEDISPYATFQLSEAGGNMSQP 1723
            :..|...|.:.||....:    ::|...|::..:          :|.:.|... ||.|.|:..
Worm  4904 KWYKNDQEIKPNSHLEAKKIGPKKYELAINRAQL----------DDGADYKVV-LSNAAGDCD-- 4955

  Fly  1724 HHGGPANTLLHSFMYHERALAEG-----CSSPPPAASKNR----------RRHSRKTEPES---- 1769
                 ::..|.....:...:.:|     ...|.|...|.:          .::.::.:|::
Worm  4956 -----SSAALTVVKPNVLKIVDGLKDVDVEEPQPVELKVKVEGIPKVIKWYKNGQELKPDADGFK 5015

  Fly  1770 --EESESDQDQLTSSRTESSN---------QHEGKIKHSIIYHGAQSSTSSD-------LSPMSE 1816
              |:.||.:..||...::.|:         ..:|::....:.| .:|:.||:       |||:.:
Worm  5016 FEEKPESGEFSLTIPSSKKSDGGAYRVVLGNDKGEVYSGSVVH-VKSAKSSEPTSGANFLSPLKD 5079

Fly 1817 1816
Worm 5080 5079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845	23/90 (26%)
		Ig	138..>203	CDD:299845	18/149 (12%)
		I-set	238..327	CDD:254352	27/96 (28%)
		Ig	247..327	CDD:299845	24/87 (28%)
		I-set	332..418	CDD:254352	24/100 (24%)
		IGc2	344..407	CDD:197706	17/71 (24%)
		IG_like	432..517	CDD:214653	24/90 (27%)
		IGc2	436..507	CDD:197706	21/76 (28%)
		I-set	521..610	CDD:254352	27/122 (22%)
		IGc2	533..597	CDD:197706	20/69 (29%)
		Ig	630..699	CDD:143165	18/95 (19%)
		IG_like	714..802	CDD:214653	22/92 (24%)
		Ig	725..802	CDD:299845	20/81 (25%)
		Ig	823..894	CDD:143165	24/70 (34%)
		FN3	906..1006	CDD:238020	24/136 (18%)
		FN3	1013..1111	CDD:238020	26/124 (21%)
		FN3	1119..1209	CDD:238020	18/121 (15%)
		FN3	1219..1313	CDD:238020	31/131 (24%)
		Ig	1336..1402	CDD:143165	17/70 (24%)
		FN3	1409..1498	CDD:238020	20/102 (20%)
		FN3	1515..1588	CDD:238020	14/86 (16%)
unc-89	NP_001020985.1	SH3	65..124	CDD:302595
		RhoGEF	153..328	CDD:238091
		PH_unc89	341..455	CDD:270134
		Ig	568..634	CDD:143165
		I-set	<570..638	CDD:254352
		I-set	648..737	CDD:254352
		Ig	661..728	CDD:299845
		I-set	748..837	CDD:254352
		IGc2	761..827	CDD:197706
		I-set	844..935	CDD:254352
		I-set	946..1034	CDD:254352
		Ig	954..1034	CDD:299845
		I-set	1044..1133	CDD:254352
		Ig	<1060..1132	CDD:299845
		I-set	1140..1237	CDD:254352
		Ig	1146..1237	CDD:299845
		RCSD	1384..1491	CDD:282963
		RCSD	1481..1590	CDD:282963
		RCSD	1576..1678	CDD:282963
		RCSD	1735..1819	CDD:282963
		RCSD	1789..>1860	CDD:282963
		I-set	1982..2068	CDD:254352
		Ig	2009..2069	CDD:299845
		Ig_TrkABC_d4	2075..2164	CDD:143173
		I-set	2081..2164	CDD:254352
		I-set	2171..2262	CDD:254352
		Ig	<2198..2262	CDD:299845
		I-set	2269..2360	CDD:254352
		Ig	2270..2360	CDD:299845
		I-set	2367..2456	CDD:254352
		IGc2	2380..2446	CDD:197706
		I-set	2463..2554	CDD:254352
		Ig	2490..2554	CDD:299845
		I-set	2563..2652	CDD:254352
		Ig	2579..2647	CDD:143165
		I-set	2659..2747	CDD:254352
		Ig	2667..2747	CDD:299845
		I-set	2754..2843	CDD:254352
		Ig	2777..2841	CDD:143165
		I-set	2887..2981	CDD:254352
		Ig	2904..2978	CDD:143165
		I-set	2994..3082	CDD:254352
		IGc2	3009..3072	CDD:197706
		I-set	3087..3183	CDD:254352	23/88 (26%)
		Ig	3101..3179	CDD:299845	22/84 (26%)
		I-set	3189..3279	CDD:254352	7/89 (8%)
		Ig	3206..3276	CDD:299845	7/69 (10%)
		I-set	3286..3377	CDD:254352	17/102 (17%)
		Ig	3303..3374	CDD:143165	10/82 (12%)
		I-set	3384..3472	CDD:254352	28/98 (29%)
		Ig	3402..3472	CDD:143165	23/80 (29%)
		I-set	3482..3573	CDD:254352	23/95 (24%)
		Ig	3501..3570	CDD:143165	18/73 (25%)
		I-set	3580..3671	CDD:254352	25/99 (25%)
		IGc2	3593..3661	CDD:197706	21/76 (28%)
		I-set	3686..3776	CDD:254352	24/92 (26%)
		IGc2	3699..3766	CDD:197706	20/69 (29%)
		I-set	3817..3902	CDD:254352	16/84 (19%)
		Ig	3834..3899	CDD:143165	14/64 (22%)
		I-set	3920..4010	CDD:254352	23/94 (24%)
		Ig	3921..4010	CDD:299845	22/93 (24%)
		I-set	4018..4107	CDD:254352	31/104 (30%)
		Ig	4046..4107	CDD:299845	20/76 (26%)
		Ig	4108..4201	CDD:299845	16/99 (16%)
I-set	4114..4202	CDD:254352	16/94 (17%)
I-set	4212..4298	CDD:254352	20/108 (19%)
IGc2	4226..4288	CDD:197706	14/71 (20%)
I-set	4302..4388	CDD:254352	20/101 (20%)
Ig	4319..4384	CDD:143165	13/76 (17%)
I-set	4400..4486	CDD:254352	17/93 (18%)
Ig	4417..4482	CDD:143165	14/72 (19%)
I-set	4493..4581	CDD:254352	19/92 (21%)
Ig	4518..>4566	CDD:299845	9/47 (19%)
I-set	4588..4679	CDD:254352	20/98 (20%)
Ig	4599..4679	CDD:299845	20/87 (23%)
I-set	4685..4772	CDD:254352	18/98 (18%)
Ig	<4713..4772	CDD:299845	14/70 (20%)
I-set	4781..4869	CDD:254352	15/104 (14%)
Ig	4790..4869	CDD:299845	15/95 (16%)
I-set	4873..4962	CDD:254352	25/132 (19%)
Ig	4891..4960	CDD:299845	16/99 (16%)
I-set	4969..5059	CDD:254352	13/90 (14%)
Ig	4985..5051	CDD:143165	9/65 (14%)
I-set	5073..5161	CDD:254352	3/7 (43%)
Ig	5094..5161	CDD:299845
I-set	5171..5260	CDD:254352
Ig	5189..5255	CDD:143165
I-set	5277..5367	CDD:254352
IGc2	5291..5357	CDD:197706
I-set	5383..5473	CDD:254352
IGc2	5397..5463	CDD:197706
I-set	5487..5577	CDD:254352
IGc2	5501..5567	CDD:197706
I-set	5595..5684	CDD:254352
Ig	5614..5681	CDD:143165
I-set	5701..5791	CDD:254352
IGc2	5714..5781	CDD:197706
I-set	5815..5905	CDD:254352
IGc2	5828..5895	CDD:197706
I-set	5925..6015	CDD:254352
Ig	5939..6015	CDD:299845
I-set	6038..6131	CDD:254352
Ig	6058..6126	CDD:143165
I-set	6150..6240	CDD:254352
Ig	6168..6237	CDD:143165
FN3	6275..6358	CDD:214495
IG_like	6413..6501	CDD:214653
Ig	6427..6499	CDD:143165
I-set	6507..6597	CDD:254352
Ig	6529..6594	CDD:143165
PK_Unc-89_rpt1	6620..6878	CDD:271011
S_TKc	6640..6878	CDD:214567
I-set	7528..7616	CDD:254352
Ig	7546..7616	CDD:299845
FN3	7621..7716	CDD:238020
STKc_Unc-89_rpt2	7781..8035	CDD:271014
S_TKc	7793..8035	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910