DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam2 and Il1rl1

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001020773.1	Gene:	Il1rl1 / 17082	MGIID:	98427	Length:	567	Species:	Mus musculus

Alignment Length:	424	Identity:	88/424 - (20%)
Similarity:	143/424 - (33%)	Gaps:	133/424 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 RLNIYGLPYIRLIPKVTAVSG---------ETLNLKCPVAG---YPIEEIHWERGGRELPDDIRQ 566
            |:.::.|..:.|...:|...|         |.|.::||..|   ||: |.::......:|...|.
Mouse     6 RMGLWALAILTLPMYLTVTEGSKSSWGLENEALIVRCPQRGRSTYPV-EWYYSDTNESIPTQKRN 69

  Fly   567 R--VQPDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNM--- 626
            |  |..| .|...|. :..|||:|.|..|:.   :..::|.:.|.:..|  |...||....|
Mouse    70 RIFVSRD-RLKFLPA-RVEDSGIYACVIRSP---NLNKTGYLNVTIHKK--PPSCNIPDYLMYST 127

  Fly   627 ---GDR-ASLTCSVVKGDL---PLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGN 684
               .|: ..:||..:  ||   ...:.|.|:.:.:...:..:      :.|.|.|:|:..|..|:
Mouse   128 VRGSDKNFKITCPTI--DLYNWTAPVQWFKNCKALQEPRFRA------HRSYLFIDNVTHDDEGD 184

  Fly   685 YSCVVRNSAAEVENSQALLVNVPPRWIVE-------PVDANVERNRHIMLHCQAQGVPTPSIVWK 742
            |:|    .....||....:|.....:.||       ||..|...|     |.....:..|:.:..
Mouse   185 YTC----QFTHAENGTNYIVTATRSFTVEEKGFSMFPVITNPPYN-----HTMEVEIGKPASIAC 240

  Fly   743 KATGSKSGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPY 807
            .|                  ..|.||..|..|        |.|.|.   |.:|...:.::..
Mouse   241 SA------------------CFGKGSHFLADV--------LWQINK---TVVGNFGEARIQE--- 273

  Fly   808 FSSTSRSVMVKKGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQI 872
                                             ..|:|  ..|:|         ..|.:::.|:|
Mouse   274 ---------------------------------EEGRN--ESSSN---------DMDCLTSVLRI 294

  Fly   873 RTVDATD-SGPYFCRASNLYGNDQQLVQLQVQEP 905
            ..|...| |..|.|.|.||:|..:..::|:.::|
Mouse   295 TGVTEKDLSLEYDCLALNLHGMIRHTIRLRRKQP 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653	1/2 (50%)
		IGc2	436..507	CDD:197706
		I-set	521..610	CDD:254352	26/102 (25%)
		IGc2	533..597	CDD:197706	22/77 (29%)
		Ig	630..699	CDD:143165	15/71 (21%)
		IG_like	714..802	CDD:214653	17/87 (20%)
		Ig	725..802	CDD:299845	13/76 (17%)
		Ig	823..894	CDD:143165	16/71 (23%)
		FN3	906..1006	CDD:238020	88/424 (21%)
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Il1rl1	NP_001020773.1	Ig	33..97	CDD:416386	20/66 (30%)
		Ig strand B	37..42	CDD:409353	1/4 (25%)
		Ig strand C	51..55	CDD:409353	2/4 (50%)
		Ig strand C'	60..62	CDD:409353	0/1 (0%)
		Ig strand D	70..74	CDD:409353	1/3 (33%)
		Ig strand E	76..80	CDD:409353	2/4 (50%)
		Ig strand F	89..97	CDD:409353	3/7 (43%)
		Ig2_IL1R-like	124..210	CDD:409415	20/97 (21%)
		Ig strand B	135..139	CDD:409415	0/3 (0%)
		Ig strand C	150..154	CDD:409415	0/3 (0%)
		Ig strand E	170..174	CDD:409415	2/3 (67%)
		Ig strand F	184..189	CDD:409415	2/8 (25%)
		Ig strand G	201..204	CDD:409415	0/2 (0%)
		Flexible linker. /evidence=ECO:0000250	204..216		2/11 (18%)
		Ig	<291..324	CDD:416386	11/32 (34%)
		Ig strand E	291..294	CDD:409353	1/2 (50%)
		Ig strand F	305..310	CDD:409353	2/4 (50%)
		Ig strand G	318..321	CDD:409353	0/2 (0%)
		TIR	385..540	CDD:396246
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910