DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam2 and Papln

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001192272.1	Gene:	Papln / 170721	MGIID:	2386139	Length:	1302	Species:	Mus musculus

Alignment Length:	504	Identity:	139/504 - (27%)
Similarity:	183/504 - (36%)	Gaps:	148/504 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 INSHRGIISPSVVE-----HTAHVQVSQ------------DEGAVLLCVAQGCPSPEYS-WFTHN 275
            :|:.||...|...|     |.|||...|            ..||.:    ...|||..| |....
Mouse   819 MNTCRGQHGPRRPEAGAAGHRAHVDGGQRGPGGQQEPDWHRAGATI----PRLPSPSGSPWRREQ 879

  Fly   276 GAGP-----LPVL----SGPRVRLLGPIL---AIEAVTGEDSGVYKCTAGNVGGEASAELRLTVA 328
            ...|     :|..    .|..:|...|.|   |..||....|..|:...      |.:|..|..|
Mouse   880 EPAPGEPPHIPAYGNRPGGQEIRPRVPGLDREARPAVPPTHSPSYRIRL------AGSEPSLVQA 938

  Fly   329 TP---IQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKDGRQLPSSG---RVEDTLVV 387
            .|   :|:....|:.|....|                     |.|:||.:.|:.   :.:.:|::
Mouse   939 APGQAVQLFCPGNIPSEFQAG---------------------WQKEGRPISSNRYQLQADGSLII 982

  Fly   388 PRVSRENRGMYQCVVRR--------------------PEGDT--FQATAELQLGDAPP------- 423
            .|:..|:.|:|.|...|                    |||..  |.......||..||
Mouse   983 SRLRPEDAGIYSCGSHRPGHEPQEIQLRVTGGDMAVFPEGQPRHFPEPRNPDLGHGPPHRGTGAE 1047

  Fly   424 -----VLLYSF--------IEQT------LQPGPAVSLKCSAAGNPTPQISWTLDGFPLPSNGRF 469
                 ||..|.        :::|      ..||..:.|.|.|.|.|.|.|.|..|| .|.|:.|
Mouse  1048 AGGHRVLSPSHPRPATRLRLDRTQPGVVDASPGQRIRLTCRAEGFPVPTIEWQRDG-QLVSSPR- 1110

  Fly   470 MIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQH------AARLNIYGLPYIRLIPK 528
               ..:...|.::    ||.|.|||||.|:|:|.|...|.|.      ...|.|.|||     |.
Mouse  1111 ---HQVQPDGSLV----ISRVDVEDGGYYSCVAFNGQDRDQRWVQLRVLRELTITGLP-----PA 1163

  Fly   529 VTAVSGETLNLKCPVAGYPIEEIHWERGGRELP---DDIRQRVQPDGSLTISPVQKNSDSGVYTC 590
            ||...|:|..|.|.|||..: .|.|.|.|  ||   |..|....|||:|.|..::.. |.|.|||
Mouse  1164 VTVAEGDTARLLCVVAGESV-NIRWSRNG--LPIQADGHRVHQSPDGTLLIHNLRPR-DEGSYTC 1224

  Fly   591 WA-RNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASL-TCSVV 637
            .| |..|..|  ||.||.|.:|...:  |:..|..:..|:..| .|:::
Mouse  1225 SAFRGSQAVS--RSTEVKVALPAPAA--QSRDLGKDCIDQPELANCALI 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352	28/118 (24%)
		Ig	247..327	CDD:299845	23/104 (22%)
		I-set	332..418	CDD:254352	20/110 (18%)
		IGc2	344..407	CDD:197706	14/85 (16%)
		IG_like	432..517	CDD:214653	32/96 (33%)
		IGc2	436..507	CDD:197706	28/70 (40%)
		I-set	521..610	CDD:254352	38/92 (41%)
		IGc2	533..597	CDD:197706	27/67 (40%)
		Ig	630..699	CDD:143165	2/9 (22%)
		IG_like	714..802	CDD:214653
		Ig	725..802	CDD:299845
		Ig	823..894	CDD:143165
		FN3	906..1006	CDD:238020
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Papln	NP_001192272.1	TSP1	30..81	CDD:214559
		ADAM_spacer1	184..299	CDD:368694
		TSP1	309..362	CDD:214559
		TSP1	389..447	CDD:214559
		TSP1	447..504	CDD:214559
		TSP1	511..562	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..737
		Kunitz_BPTI	771..822	CDD:333766	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..924		26/105 (25%)
		Papilin_u7	831..922	CDD:374683	22/94 (23%)
		Ig	932..>995	CDD:386229	18/83 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1064		8/39 (21%)
		I-set	1070..1141	CDD:369462	29/79 (37%)
		Ig	1157..1241	CDD:386229	40/94 (43%)
		PLAC	1257..1289	CDD:370061	3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900