DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and CNTN4

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:NP_001193884.1 Gene:CNTN4 / 152330 HGNCID:2174 Length:1026 Species:Homo sapiens


Alignment Length:1272 Identity:291/1272 - (22%)
Similarity:454/1272 - (35%) Gaps:370/1272 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LLLLNLDNTCSEPFEAHLRGPGFVMEPPGRVEF---SNSSGGWLDCSASGSPQPTVDWVHADGSA 72
            :|.|..|:|        |.||.|:.| |..|.|   |......|:|...|:|:|.:.| ..:|:.
Human    14 ILCLADDST--------LHGPIFIQE-PSPVMFPLDSEEKKVKLNCEVKGNPKPHIRW-KLNGTD 68

  Fly    73 VTEIHGVRRVLRNGTLVLMPFAAAAYHQDVHNT----IYRCIASNSVGRIVSRDVQVRAVVAQAY 133
            |......|..:..|:|::         .:.:.|    .|:|.|:||.|.||||:.:::......:
Human    69 VDTGMDFRYSVVEGSLLI---------NNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNF 124

  Fly   134 KVDV-EVLSAARGCTAILRCVVPTFVKELVRVVSWVHEPAIYIYPSLQGDGKFHLLPTGELLIHN 197
            |... ..:|..||...:|.|..|....||  ..:|:...    |||.|.:.:|....||.|.|..
Human   125 KTRTRSTVSVRRGQGMVLLCGPPPHSGEL--SYAWIFNE----YPSYQDNRRFVSQETGNLYIAK 183

  Fly   198 LQESDESQSFRCRSMHRLTRQVVVSSPTR--LRINSHRGIISPSV-VEHTAHVQVSQDEGAVLLC 259
            :::||.. ::.|...:.:|...|:..||.  ||.:...|...|.: |:....|..::.....|.|
Human   184 VEKSDVG-NYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLEC 247

  Fly   260 VAQGCPSPEYSWFTHNGAGPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNVGGEASAELR 324
            .|.|.|.|...|...:|.   |:....|......||.|.....||:|:|:|.|.|..|:..|..:
Human   248 FALGNPVPTIIWRRADGK---PIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQ 309

  Fly   325 LT-VATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGM-QNILWYKDGRQLPSSGRVEDTLVV 387
            || .|.|..::   .:..:|                 |.| :|:.|                   
Human   310 LTFYAQPNWIQ---KINDIH-----------------VAMEENVFW------------------- 335

  Fly   388 PRVSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKCSAAGNPTP 452
                                                                   :|.|.|.|.|
Human   336 -------------------------------------------------------ECKANGRPKP 345

  Fly   453 QISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAARLNI 517
            ...|..:|.||.:..|..|.|         ..:||:.|.:.|.|.|.|:|||:.|.:...|.|::
Human   346 TYKWLKNGEPLLTRDRIQIEQ---------GTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSV 401

  Fly   518 --YGLPYIR-LIPKVT--AVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQRVQPDGSLTIS 577
              .|..:.| |:.:||  .|.||.: ::|.....|.....|::|...|.::.|..:..||:|.|.
Human   402 IAVGPDFSRTLLKRVTLVKVGGEVV-IECKPKASPKPVYTWKKGRDILKENERITISEDGNLRII 465

  Fly   578 PVQKNSDSGVYTCWARNKQGHSARRSGEVT------VIVPPKLSPFQTNILQLNMGDRASLTCSV 636
            .|.| ||:|.|||.|.|..| :|..:|.:.      |:|||       :.:.:.:|:...|.|.|
Human   466 NVTK-SDAGSYTCIATNHFG-TASSTGNLVVKDPTRVMVPP-------SSMDVTVGESIVLPCQV 521

  Fly   637 VKG-DLPLTINWRKDGRPIDPTQHMSVKQVDQYNSI--------LVIENLGSDHTGNYSCVVRNS 692
            ... .|.:...|..:|..||     ..:..|.:..:        |:|.|:...|.|.|.|:|:.|
Human   522 THDHSLDIVFTWSFNGHLID-----FDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTS 581

  Fly   693 AAEVENSQALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVP-----------TPSIVWKKATG 746
            ...:..:..|:|..||                        |.|           |..:.|:....
Human   582 VDRLSAAADLIVRGPP------------------------GPPEAVTIDEITDTTAQLSWRPGPD 622

  Fly   747 SKSGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSST 811
            :.|         |.|                   .|:.||......|...|            ||
Human   623 NHS---------PIT-------------------MYVIQARTPFSVGWQAV------------ST 647

  Fly   812 SRSVMVKKGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVD 876
            ...::..|..||    .|.|               |||...|                 :.||| 
Human   648 VPELIDGKTFTA----TVVG---------------LNPWVEY-----------------EFRTV- 675

  Fly   877 ATDSGPYFCRASNLYGNDQQLVQLQVQEPPLP----------PSVLEAAMI----SSRSVNIKWQ 927
                      |:|:.|         :.||..|          |.|..|.:.    |...:.|.|:
Human   676 ----------AANVIG---------IGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWE 721

  Fly   928 --PKTLGTGDVTKYIVEFREADHSLPPALFVDQWQQIEVKDPPHFNAMIENLKPATRYAFRVIAE 990
              |:.|..|....|:|.||      |....:.....:...|...:....|::.|.:.:..:|...
Human   722 TVPEELQNGRGFGYVVAFR------PYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVF 780

  Fly   991 GSAGRSAPSQELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPELRHGDIQGYNVGY---- 1051
            .:.|....|...:|.:..:.|..||.|:.||.||:|::.:.|.:|| |...|.||||.|.|    
Human   781 NNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPL-EKNRGRIQGYEVKYWRHE 844

  Fly  1052 -------KLSSSGN-TAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVGPGPLSEPTA 1108
                   |:.:.|| |:...|::.|.                ..|.:.|:|:|..|.||.|....
Human   845 DKEENARKIRTVGNQTSTKITNLKGS----------------VLYHLAVKAYNSAGTGPSSATVN 893

  Fly  1109 AQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLIFEPIIDDIQPSKDEVESR 1173
            ..|.:..||:||.::...: |...:.::|...........::|||:::.   .:.|.|...:|:.
Human   894 VTTRKPPPSQPPGNIIWNS-SDSKIILNWDQVKALDNESEVKGYKVLYR---WNRQSSTSVIETN 954

  Fly  1174 KTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPL 1210
            ||:    |...|....:|.|::...:..|||..|:.:
Human   955 KTS----VELSLPFDEDYIIEIKPFSDGGDGSSSEQI 987

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845 22/79 (28%)
Ig 138..>203 CDD:299845 19/64 (30%)
I-set 238..327 CDD:254352 27/90 (30%)
Ig 247..327 CDD:299845 25/80 (31%)
I-set 332..418 CDD:254352 5/86 (6%)
IGc2 344..407 CDD:197706 4/63 (6%)
IG_like 432..517 CDD:214653 25/84 (30%)
IGc2 436..507 CDD:197706 22/70 (31%)
I-set 521..610 CDD:254352 31/97 (32%)
IGc2 533..597 CDD:197706 22/63 (35%)
Ig 630..699 CDD:143165 18/77 (23%)
IG_like 714..802 CDD:214653 12/98 (12%)
Ig 725..802 CDD:299845 12/87 (14%)
Ig 823..894 CDD:143165 13/70 (19%)
FN3 906..1006 CDD:238020 22/115 (19%)
FN3 1013..1111 CDD:238020 33/109 (30%)
FN3 1119..1209 CDD:238020 20/89 (22%)
FN3 1219..1313 CDD:238020
Ig 1336..1402 CDD:143165
FN3 1409..1498 CDD:238020
FN3 1515..1588 CDD:238020
CNTN4NP_001193884.1 Ig 25..118 CDD:325142 30/103 (29%)
Ig 120..213 CDD:325142 26/99 (26%)
Ig 225..313 CDD:325142 27/90 (30%)
Ig 318..401 CDD:325142 30/185 (16%)
Ig5_Contactin 422..494 CDD:319278 25/74 (34%)
Ig6_Contactin-4 513..597 CDD:143261 20/88 (23%)
FN3 597..690 CDD:238020 33/212 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..710 5/24 (21%)
FN3 703..795 CDD:238020 18/97 (19%)
FN3 804..896 CDD:238020 33/108 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 886..907 8/20 (40%)
FN3 904..989 CDD:238020 20/92 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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