DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and Dscaml1

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001074739.2	Gene:	Dscaml1 / 114873	MGIID:	2150309	Length:	2053	Species:	Mus musculus

Alignment Length:	2153	Identity:	664/2153 - (30%)
Similarity:	1023/2153 - (47%)	Gaps:	215/2153 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWISSRFFVILLLLNLDNTCSEPFEAHLRGPGFVMEPPGRVEFSNSSGGWLDCSASGSPQPTVDW 65
            ||:.:   .:|||.:|.....|.....|.   ||.:....|.||:|.|..:.|.|:|||...:.|
Mouse     1 MWLVT---FLLLLDSLHKARPEDVGTSLY---FVNDSLQHVTFSSSVGVVVPCPAAGSPSAALRW 59

  Fly    66 VHADGSAVTEIHGVRRVLRNGTLVLMPFAAAAYHQDVHNTIYRCIASNSVGRIVSRDVQVRAVVA 130
            ..|.|..:.::..:|.|..||||.|.||:.:|::..:|:..|.|.|.|:.|:|.|.:::::||..
Mouse    60 YLATGDDIYDVPHIRHVHANGTLQLFPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRIKAVFR 124

  Fly   131 QAYKVDVEVLSAARGCTAILRCVVPTFVKELVRVVSWVHEPAIYIYPSLQGDGKFHLLPTGELLI 195
            :.|.|.||...:.||..|:.:|::|:.|:|.|.||||..:..     |:..:.:|.:...|.|.|
Mouse   125 EPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTV-----SITPENRFFITSHGGLYI 184

  Fly   196 HNLQESDESQSFRCRSMHRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQVSQDEGAVLLCV 260
            .::|:.|...::||.:.|:.:.:...|:..||.:......| |::::.....:|.......|.|.
Mouse   185 SDVQKEDALSTYRCITQHKYSGETRQSNGARLSVTDPAESI-PTILDGFHSQEVWTGHSVELPCA 248

  Fly   261 AQGCPSPEYSWFTHNGAGPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNVGGEASAELRL 325
            |.|.|.|...|.  ....|||..|....|:.|  |.|..:..||||.|.|...|..|.|.|...|
Mouse   249 ASGYPIPAIRWL--KDGRPLPADSRWAKRITG--LTISDLRTEDSGTYICEVTNTFGSAEANGIL 309

  Fly   326 TVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKD------GRQLPSSGRVEDT 384
            ||..|:.|.::|..|...:|.|....|.:|  |||  ...|.||::      |..:...|...:|
Mouse   310 TVIDPLHVTLTPKKLKTGIGSTVILSCALT--GSP--EFTIRWYRNTELVLPGEAISIRGLSNET 370

  Fly   385 LVVPRVSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKCSAAGN 449
            |::....:.:.|.|||...| :..|.|..|.:.|.|..|.::.||.|:.:.||...||.|:|.|.
Mouse   371 LLISSAQKSHSGAYQCFATR-KAQTAQDFAIIVLEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGA 434

  Fly   450 PTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAAR 514
            |.|.::|.||..|:..:|.....||....|..|||:|::...:.|||.|.|.|.|..|..::.||
Mouse   435 PPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNSVGSAEYQAR 499

  Fly   515 LNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQRVQPDGSLTISPV 579
            :|:.|.|.||.:..:|||:|....:.|.|.|||...|.|.:....|||:.||.|..:|:|.::.|
Mouse   500 INVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDV 564

  Fly   580 QKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVVKGDLPLT 644
            ||..|.|.|.|....:...|..:|..|.|.|||.:.||:  ....::|....:.|.|..||:|:.
Mouse   565 QKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFE--FPPASIGQLLYIPCVVSSGDMPIR 627

  Fly   645 INWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQALLVNVPPR 709
            |.|||||:.|.....::::. .::.|.|.|.::...|.|||:|:..|:||.|...:.|:|.||||
Mouse   628 ITWRKDGQVIISGSGVTIES-KEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPR 691

  Fly   710 WIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFT---KLLGNGSLLL 771
            ::|:|.:.:....:..:|:|...|.|.|.::||.|.|  ||..::....|.|   ::|.|.|||:
Mouse   692 FVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKG--SGNPQQYHPVPLTGRIQILPNSSLLI 754

  Fly   772 QHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPIN 836
            :||.|:..|:|||||:||:||.|.|.:.|.|......:|...:.:..||....|.|...|::||.
Mouse   755 RHVLEEDIGYYLCQASNGVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHPKELNCTARGERPII 819

  Fly   837 IVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQ 901
            |.| ..|...::|....:.::..:...|.|.:.|:::..|..||..:.|.|.|.||.|:.|:||.
Mouse   820 IRW-EKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLT 883

  Fly   902 VQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQW---QQIE 963
            |||||.||. ||...:.:||:|::|..:..|...:|.:.:|::...         |.|   |...
Mouse   884 VQEPPDPPE-LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKS---------DSWDFKQSTR 938

  Fly   964 VKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARPLSSTEL 1028
            ...|....|.|.:|.||:.|:.|:.:....|||.||:||.:.||...|.|||:.::.:|::|..:
Mouse   939 NISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSI 1003

  Fly  1029 LISWVAPLPELRHGDIQGYNVGYKLSSSG-NTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVV 1092
            .::|.||..||::|.|:||.:||:.:|.| |..|:...:...||  :....|..|.|||:|.|||
Mouse  1004 QVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGD--SEVYTLDNLKKFAQYGVVV 1066

  Fly  1093 QAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLIFE 1157
            ||||:.|.||.|....|.|:|||||:|||:||..:::|....:||..||....||:|:||::||.
Mouse  1067 QAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW 1131

  Fly  1158 PIIDDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPEAP 1222
            .:.  :.....|:::..||...:.|.|:.|:||||:||||:|:.||||.|..|:..::||||..|
Mouse  1132 SLY--VDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPP 1194

  Fly  1223 ADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREELNNEKRSLPSQQAYYEAKGLHPH 1287
            |.||.|.||:.|:.:|||||.:|||||.||:::.......:...:|..:.| :|.:|....|:..
Mouse  1195 AGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSP-EQLFYRIAHLNRG 1258

  Fly  1288 MEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTLPCTAVGKPKR--EW 1350
            .:|..||.|.|..|.|.||...:.....:.||:||||||.|..||...|.|||.:||.|..  :|
Mouse  1259 QQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKW 1323

  Fly  1351 FK-SDVALRQGGLHNSQLL-DSGDLIISSLQLADGGNYSCQVDNGIGTDRLTHTLIVQVPPTAPV 1413
            .| |:.:.....|...:|: .:|.|::.:::..|.|.|:|...|..|.|.:...|:|||||..|.
Mouse  1324 TKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR 1388

  Fly  1414 LYVTSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQ---LSRHASSHELKGLMCGSTY 1475
            |.|:..::|||.:.|..|..|.:.|.|:.|.|  :..|::|.:   :|....|.:|..|.||:.|
Mouse  1389 LTVSKTSASSITLTWIPGDNGGSSIRGFVLQY--SVDNSEEWKDVFISSSERSFKLDSLKCGTWY 1451

  Fly  1476 QIHLSAQNKVGTSPTSTILHVRTQGQSPGHPASTALLAP-NSTSLLVRLHSWPDNGCPLLYFVLQ 1539
            ::.|:|:|.||:...|.|:..:|.|:.|.......|... |||...:.|..|.:.|||:...||:
Mouse  1452 KVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLE 1516

  Fly  1540 YRAVTDDPDAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHNVAGISQAEFNFVTLTKDGDPP 1604
            ||     |...|............:.:..|:.:|.|:|||.|.|.||.......|.||..||...
Mouse  1517 YR-----PKGTWAWQGVRANSSTEVFLTELREATWYELRMRACNSAGCGNETAQFATLDYDGSTI 1576

  Fly  1605 PPEIMHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYR-----HMLKNAPPLAEQSQI 1664
            ||....:|.......:|   .:..|.|.|..|:  .::.::...|     ..|::|..|||. .|
Mouse  1577 PPIKSAQGEGDDVKKLF---TIGCPVILATLGV--ALLFVVRKKRKEKRLKRLRDAKSLAEM-LI 1635

  Fly  1665 QKESLENRANSEAA----QRERYYATIHKVSMQNNDK------------IPETSEDISPYATFQL 1713
            .|   .||:.....    |..|.:..|.:|.:...||            ||.|..:.|.....|.
Mouse  1636 SK---NNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQLGDDKATIPVTDAEFSQAVNPQS 1697

  Fly  1714 SEAGGNMSQPHHGGPANTLLHSFMYHERALAEGCSSPP---PAASKN-RRRHSRKTEPESE---- 1770
            ...|.::   ||  ||  |:.|    ...|.:.....|   |.:.|| :..||.:....|:
Mouse  1698 FCTGVSL---HH--PA--LIQS----TGPLIDMSDIRPGTNPVSRKNVKSAHSTRNRYSSQWTLT 1751

  Fly  1771 --ESESDQDQLTS-----------------SRTESSNQHEGKIKHSIIYHGAQSSTSSDLSPMSE 1816
              ::.:....|||                 |.:.|.:|...|.::|::...:.|||..:|:...|
Mouse  1752 KCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDTDKGRNSMVSTESASSTYEELARAYE 1816

  Fly  1817 QKSLPRRGRSRYHHQQYQFSTNTTPRHHNSNKMNNNTTSNTNTTATNTTATPSTSSNSNKILSP- 1880
            ...|    ..:..|.:::. |.......:|::|...|  |.|..:..:.:|||.........||
Mouse  1817 HAKL----EEQLQHAKFEI-TECFISDSSSDQMTTGT--NENADSMTSMSTPSEPGICRFTASPP 1874

  Fly  1881 ------RGGNLKSISSTFKSQDSIQCHIPTLVKSPSISTQQQ----------KQFHKQQLQNSST 1929
                  ||.|: ::....::..|..|::|...||.:...:..          ::...:.|..:..
Mouse  1875 KPQDADRGKNV-AVPIPHRANKSDYCNLPLYTKSEAFFRKADGREPCPVVPPREASMRNLTRAYH 1938

  Fly  1930 NNSQHSSSNPNSSSLKQQQPLLITPKLHQLEANGQELLGLDGIGNSPLVACMPPSSQFRPIPHKS 1994
            ..::|.:.:|.|..|....|                     |...:...|.:|..:...|.|
Mouse  1939 TQARHLTLDPASKPLGLPHP---------------------GATAATATATLPQRTLAMPAP--- 1979

  Fly  1995 IMPAHEPPHHHNHSQQSHPHQQQQQQQHPG-TLLNPSTAMLSSKFFTAPTLPKXDTANGGSEY-- 2056
              ||...|                  ..|| |...||.|..:     ||..|. :....|..:
Mouse  1980 --PAGTAP------------------PAPGPTPSEPSAAPSA-----APPAPSTEPPRAGGPHTK 2019

  Fly  2057 VGGAMEAM 2064
            :||:.:::
Mouse  2020 MGGSRDSL 2027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845	26/75 (35%)
		Ig	138..>203	CDD:299845	19/64 (30%)
		I-set	238..327	CDD:254352	28/88 (32%)
		Ig	247..327	CDD:299845	27/79 (34%)
		I-set	332..418	CDD:254352	25/91 (27%)
		IGc2	344..407	CDD:197706	19/68 (28%)
		IG_like	432..517	CDD:214653	31/84 (37%)
		IGc2	436..507	CDD:197706	28/70 (40%)
		I-set	521..610	CDD:254352	33/88 (38%)
		IGc2	533..597	CDD:197706	23/63 (37%)
		Ig	630..699	CDD:143165	24/68 (35%)
		IG_like	714..802	CDD:214653	35/90 (39%)
		Ig	725..802	CDD:299845	34/79 (43%)
		Ig	823..894	CDD:143165	20/70 (29%)
		FN3	906..1006	CDD:238020	30/102 (29%)
		FN3	1013..1111	CDD:238020	40/98 (41%)
		FN3	1119..1209	CDD:238020	37/89 (42%)
		FN3	1219..1313	CDD:238020	35/93 (38%)
		Ig	1336..1402	CDD:143165	21/69 (30%)
		FN3	1409..1498	CDD:238020	30/91 (33%)
		FN3	1515..1588	CDD:238020	24/72 (33%)
Dscaml1	NP_001074739.2	IGc2	43..110	CDD:197706	23/66 (35%)
		Ig	125..218	CDD:353325	29/97 (30%)
		I-set	226..311	CDD:336764	28/88 (32%)
		Ig_3	317..389	CDD:339005	21/75 (28%)
		Ig	408..498	CDD:353325	33/89 (37%)
		IGc2	519..577	CDD:197706	23/57 (40%)
		Ig	615..681	CDD:319273	24/66 (36%)
		Ig_DSCAM	707..785	CDD:143211	34/79 (43%)
		Ig	803..891	CDD:353325	30/88 (34%)
		FN3	887..981	CDD:238020	31/103 (30%)
		FN3	988..1085	CDD:238020	40/98 (41%)
		FN3	1093..1186	CDD:238020	38/94 (40%)
		FN3	1191..1282	CDD:238020	35/91 (38%)
		Ig	1307..1377	CDD:319273	21/69 (30%)
		FN3	1384..1474	CDD:238020	30/91 (33%)
		FN3	1488..1560	CDD:238020	24/76 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1716..1741		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1773..1803		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1840..1862		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1974..2053		17/82 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4889
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	968	1.000	Inparanoid score	I323
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47134
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8769
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1391
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830