DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and kirrel1b

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	XP_017212964.1	Gene:	kirrel1b / 100170816	ZFINID:	ZDB-GENE-070912-173	Length:	801	Species:	Danio rerio

Alignment Length:	848	Identity:	189/848 - (22%)
Similarity:	296/848 - (34%)	Gaps:	248/848 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 EQTLQPGPAVSLKCSAAGNPTPQISWTLDGFPLPSNG-----------RFM-IGQYITVHGDVIS 483
            :|::..|..|.|.| ...|.|..:.||.||..|....           |.| :|||
Zfish    33 DQSVVIGERVVLSC-VVFNYTGIVQWTKDGLALGIGEDLRAWPRYRVLRIMDVGQY--------- 87

  Fly   484 HVNISHVMVEDGGEYACIAENRAGRVQHAARLNIY----GLPYIRLIPKVTAVSGETLNLKCPVA 544
            ::.|:...:.|...|.|.|...|.| ...|:|.:.    | |.|...|::...:|.:.||.|...
Zfish    88 NLEITSADLTDDSLYECQATEAALR-SRRAKLTVLIPPDG-PVIEGSPEILLTAGTSFNLTCVSR 150

  Fly   545 G-YPIEEIHWERGG---------RELPDDIRQRVQPDGSLTISPVQKNSDSG-VYTCWARNKQGH 598
            | .|:..|.|.:.|         .|:..| |:||.....|.|.|:  ::|:| .:||.|.|....
Zfish   151 GAKPMSTIEWYKDGIIVEGAHTSTEVLSD-RKRVTTKSFLEIQPM--DTDTGRNFTCVASNLAAP 212

  Fly   599 SARRSGEVTVIV--PPK--LSPFQTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQH 659
            ..:|| .||:.:  ||.  ||....::|:   |:|...||........:...|.|.|..:|..:.
Zfish   213 LGKRS-TVTLNIHHPPTVILSIEPRSVLE---GERVKFTCQATANPPIMGYRWAKGGVILDGARE 273

  Fly   660 MSVKQVDQYNSILVIENLGSDH---TGNYSCVVRNSAAEVENSQALLVNVPPRWIVEPVDANVER 721
            .            |.|.. :||   |...||:|.|:......|..:.|:..|..:|||....|:.
Zfish   274 S------------VFETT-ADHSFFTEPVSCLVFNAVGSTNVSILVDVHFGPILVVEPRPVTVDV 325

  Fly   722 NRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTKLLGNGS-LLLQHVKEDREGFYLCQ 785
            :..:.|:|:..|.|..::.|.|...|              .:|.|.: |.|:.|.:...|.|:|:
Zfish   326 DSDVTLNCKWSGNPPLTLTWTKKGSS--------------MVLSNSNQLFLKSVSQADAGQYVCK 376

  Fly   786 A---NNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAV-SGDKPINIVW------M 840
            |   ..|:|.   ..:.|.||..|..||......| :|:...::|.: |...|..|||      .
Zfish   377 AIVPRIGVGE---TEVTLTVNGPPIISSEPIQYAV-RGEKGEIKCYIASTPPPDKIVWAWKENVW 437

  Fly   841 RSGKNTLNPSTNYKISVKQEATPDG-VSAELQIRTV-DATDSGPYFCRASNLYGNDQQLVQLQ-- 901
            ...:.||  ...|.:...:.||..| |.:.|.|..| :|.....|.|.|.|.:|....::.|:
Zfish   438 EKERGTL--LERYTVEQSRPATQGGAVLSTLTINNVMEADFQSTYNCTAWNAFGPGTMIITLEET 500

  Fly   902 --VQEPPLPPSVLEAAMISS-----------------------RSVNIK-------------WQP 928
              ..|..:|..|:....:.|                       |.|.:|             .:.
Zfish   501 DIASEDIVPVGVIAGGSVGSSILLLLLLFALIFYLYRQRKSSRRGVTLKPDIKVETVNKETNLEE 565

  Fly   929 KTLGTGDVTKYIVEFREADHSLPPAL--------FVDQW---------------QQIEVKDPPHF 970
            :.......|:.:    :|.:|..|::        |.|..               ::.|.|||.:
Zfish   566 EAASASTATRMV----KAMYSFLPSVSLSPSTQPFKDDMDLKQDLQTETLEPKVEEYEAKDPTN- 625

  Fly   971 NAMIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSAR---PLSSTELLISW 1032
              ...|::..|....|     |:.||...||.        .|..|.|:||.   |.:
Zfish   626 --GYYNVRATTHDEVR-----SSTRSLLYQEF--------RAPNPASVSASTGGPAN-------- 667

  Fly  1033 VAPLPELRHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQ 1097
            :.|.|..|          |:...:...|:|                     .:|.:..:.:| :|
Zfish   668 IHPAPTGR----------YEARPTSRMAHN---------------------TYAHFNTIARA-SQ 700

  Fly  1098 VGP--GPLSEPTAAQTMEDVPSRPP--EDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLIFEP 1158
            :.|  .|:|:.|      |.|:...  |.....|..|.:...:.|             |:|.|.|
Zfish   701 IQPPANPVSKTT------DYPAERGLLESTNPLAFDSYAYSTTPQ-------------YRLGFAP 746

  Fly  1159 IID 1161
            .::
Zfish   747 PLE 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653	26/96 (27%)
		IGc2	436..507	CDD:197706	21/82 (26%)
		I-set	521..610	CDD:254352	30/99 (30%)
		IGc2	533..597	CDD:197706	23/74 (31%)
		Ig	630..699	CDD:143165	15/71 (21%)
		IG_like	714..802	CDD:214653	21/91 (23%)
		Ig	725..802	CDD:299845	19/80 (24%)
		Ig	823..894	CDD:143165	22/79 (28%)
		FN3	906..1006	CDD:238020	24/158 (15%)
		FN3	1013..1111	CDD:238020	18/102 (18%)
		FN3	1119..1209	CDD:238020	8/45 (18%)
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
kirrel1b	XP_017212964.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810