DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and cntn3a.2

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	XP_001340839.5	Gene:	cntn3a.2 / 100000688	ZFINID:	ZDB-GENE-090312-57	Length:	1023	Species:	Danio rerio

Alignment Length:	1155	Identity:	285/1155 - (24%)
Similarity:	452/1155 - (39%)	Gaps:	255/1155 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 SQDEGAVLLCVAQGCPSPEYSWFTHNGAGPLPVLS-GPRVRLLGPILAIEAV-TGEDSGVYKCTA 312
            |.:|.|.|.|.|:|.|:|:|.|..:   |.|..|| ..|.||.|..|.|.:: ..:|.|:|:|||
Zfish    42 SLEEEATLACDAKGIPAPQYRWSLN---GTLINLSTDSRRRLSGGNLVIRSLDRAQDGGIYQCTA 103

  Fly   313 GNVGG-----EAS---AELRLTVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSP--VGMQNIL 367
            .|..|     .||   |.|.|...|       .:.:||..|......|     |:|  .|..:..
Zfish   104 FNPHGAILSRRASLQFAYLNLKTQT-------RSAVSVREGQGVVLLC-----GTPSYAGDLSFA 156

  Fly   368 W---------YKDGRQLPSSGRVEDT--LVVPRVSRENRGMYQCVV--RRPEGDTFQATAELQL- 418
            |         .:|.|:..|    ::|  |.:.:|...:.|.|.|||  |..:|....:...|.|
Zfish   157 WVFNEYPYFVQQDNRRFVS----QETGNLYIAKVEPSDVGNYTCVVVNRITKGKVLSSPTPLVLR 217

  Fly   419 -----GDAPPVLLYSFIEQT-LQPGPAVSLKCSAAGNPTPQISW-TLDGFPLPSNGRFMIGQYIT 476
                 |:..|.:...|.:.. ...|..|:|:|.|.|||.|:|:| ..:..|.||..:..
Zfish   218 TDGVMGEYEPKIEVHFSDMVPAAKGSVVTLECFALGNPVPEITWRRANAVPFPSKVKMK------ 276

  Fly   477 VHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAARLNIYGLP-YIRLIPKVTAVSGETLNLK 540
             :.:|:  :.|.....||.|.|.|:|||:.|:.....||:.:..| :::.:..:.....|.|..:
Zfish   277 -NSNVV--LEIPSFQQEDAGGYECVAENKMGKNTVQGRLSFHAKPQWVQTMRDIALSIEERLFWE 338

  Fly   541 CPVAGYPIEEIHWERGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGE 605
            |...|.|.....|.:.|..|..:.|.::: :|:||||.|.. ||:|:|.|.|.||.|.....:..
Zfish   339 CKANGKPKPSYSWLKNGELLAAEDRIQIE-NGALTISSVNL-SDAGMYQCVAENKHGIIYFGAEL 401

  Fly   606 VTVIVPPKL--SPFQTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQY 668
            |.:..||..  ||.:| :|:...|...::.|........:|: |||....:..|..::...
Zfish   402 VVLASPPDFSRSPLRT-LLKAKTGSTVTMECKPQAFPSAITL-WRKGNEVMQRTDRITFLP---- 460

  Fly   669 NSILVIENLGSDHTGNYSCVVRNSAAEVENSQALLVNVPPRWIVEPVDANVERNRHIMLHCQAQG 733
            :..|.:.|:.....|||:|:.||.......|..|||..|.:....|:|..:.....|:|.||...
Zfish   461 DGTLRLTNVTKMDGGNYACLARNQFGTASTSGRLLVTDPTQITQGPMDMEIIVGESIVLPCQISC 525

  Fly   734 VPTPSIVWKKATGSK-----SGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTG 793
            .|...:.:..|...:     ...||.|....      :|.|::::::....|.|:|
Zfish   526 DPALDVSFSWAFNGQLLSKLDQHYEHVGGST------SGDLMIRNIQLKHAGKYVC--------- 575

  Fly   794 IGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVK 858
               |:...|.     |.::.::::.||
Zfish   576 ---VVDTDVE-----SLSAAAILIVKG-------------------------------------- 594

  Fly   859 QEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAMISSRSVN 923
            ....||||:.|      :.|||                                        :..
Zfish   595 PPGAPDGVTVE------EITDS----------------------------------------TAQ 613

  Fly   924 IKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQQI----EVKDPPHFNAMIENLKPATRYA 984
            :.|:|.......:|.||::.:.|        |...||.:    ||.|.....|.:.:|.....:.
Zfish   614 LSWRPGQDNGSPITSYIIQAKTA--------FTVGWQAVNTVPEVIDGNTLTATVVDLNAWVEFE 670

  Fly   985 FRVIAEGSAGRSAPS-QELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPE-LRHGDIQGY 1047
            |||:|..|.|...|| ..|..|||...|...|..:.....|.:||:|:| .|:|| |::||..||
Zfish   671 FRVLARNSVGVGEPSPASLKTRTEDAVPDTAPTDVGGGGGSKSELVITW-EPVPEDLQNGDGFGY 734

  Fly  1048 NVGYKLSSSGNTAYNFTSVSGDGD--GGNGELLLSGLAKFARYTVVVQAFNQVGPGPLSEPTAAQ 1110
            .:.::.....|..:..|||.....  ..|..:|     .|:.::|.|.|:|..|.||.|..|...
Zfish   735 IIAFRPLGEVNWTHAVTSVPTQSRYVYRNESIL-----PFSPFSVKVGAYNTKGQGPFSPVTIVF 794

  Fly  1111 TMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLIFEPIIDDIQP---------- 1165
            :.|:.||..|:.|...::|:..::|||....: .|..:| ||::::..  ||.:|
Zfish   795 SAENEPSGVPDGVWARSISATEIEVSWHILSV-STERVL-GYEVVYWE--DDTKPETMGKVRVSA 855

  Fly  1166 SKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPEAP---ADIKV 1227
            ::|:|.          ::|||.||.|.:.|.|....|.|.:|..:...:::..|..|   .:..:
Zfish   856 NQDKVN----------ISGLRGYTQYFLTVSAFNTAGTGPLSPTINVTTKKSPPGQPPLNVEWNL 910

  Fly  1228 VSSSSQSLYISWLP--PNEPNGVITKYSL-YTRVVNGREELNNEKRSLPSQQAYYEAKGLHPHME 1289
            :.|   .|.:.|.|  ..|....:|.|.: |.|  |..:|:|....:|.|.:....|..     :
Zfish   911 IGS---KLTVHWEPVISLEMESDVTGYQVSYRR--NRHKEINTITTNLTSVELTLPADD-----D 965

  Fly  1290 YQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTLP 1339
            |...:.|.:..|||        :.|..|....:|......|.||.. |:|
Zfish   966 YVIQIRALSDGGEG--------MPTEPINIHKLSMSVRGSRAWRPN-TIP 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352	34/86 (40%)
		Ig	247..327	CDD:299845	34/86 (40%)
		I-set	332..418	CDD:254352	22/100 (22%)
		IGc2	344..407	CDD:197706	18/77 (23%)
		IG_like	432..517	CDD:214653	27/86 (31%)
		IGc2	436..507	CDD:197706	24/71 (34%)
		I-set	521..610	CDD:254352	26/89 (29%)
		IGc2	533..597	CDD:197706	23/63 (37%)
		Ig	630..699	CDD:143165	14/68 (21%)
		IG_like	714..802	CDD:214653	17/92 (18%)
		Ig	725..802	CDD:299845	15/81 (19%)
		Ig	823..894	CDD:143165	8/70 (11%)
		FN3	906..1006	CDD:238020	23/104 (22%)
		FN3	1013..1111	CDD:238020	30/100 (30%)
		FN3	1119..1209	CDD:238020	26/99 (26%)
		FN3	1219..1313	CDD:238020	22/99 (22%)
		Ig	1336..1402	CDD:143165	2/4 (50%)
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
cntn3a.2	XP_001340839.5	Ig	28..119	CDD:299845	31/79 (39%)
		Ig	126..214	CDD:299845	22/103 (21%)
		Ig	227..315	CDD:299845	29/96 (30%)
		I-set	227..308	CDD:254352	27/89 (30%)
		I-set	318..403	CDD:254352	25/86 (29%)
		Ig	319..403	CDD:299845	24/85 (28%)
		IG_like	421..496	CDD:214653	17/79 (22%)
		Ig	424..496	CDD:299845	17/76 (22%)
		I-set	501..592	CDD:254352	19/113 (17%)
		Ig	515..596	CDD:299845	19/141 (13%)
		FN3	596..688	CDD:238020	30/145 (21%)
		FN3	701..793	CDD:238020	30/97 (31%)
		FN3	802..894	CDD:238020	26/105 (25%)
		FN3	902..987	CDD:238020	23/102 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100