DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment melt and VEPH1

DIOPT Version :9

Sequence 1:	NP_523953.2	Gene:	melt / 38785	FlyBaseID:	FBgn0023001	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	XP_011511436.1	Gene:	VEPH1 / 79674	HGNCID:	25735	Length:	844	Species:	Homo sapiens

Alignment Length:	971	Identity:	286/971 - (29%)
Similarity:	448/971 - (46%)	Gaps:	198/971 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 VLSEISPIISH--ADYVKNNNDQSVVEICVTRVLSCIRETKTAERYCAALVDLLRTCLLWNLQPS 97
            ||:..|..:.:  .||..|||||:|||||:||:.:.||||::.|::..|||.|..:||..||:|.
Human    44 VLNGRSTFLDYFLCDYQTNNNDQAVVEICITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPF 108

  Fly    98 GTTKEEPPHAKIAADIISSIFLNYDKKELMKIALPVAVQFLPKGNRELSRNLASYLSLAAIDHAG 162
            | ..|:.||||||:||:|.|..||::..:|.:|:|:||:||.:||:||.||:::|||||||..|.
Human   109 G-KDEDTPHAKIASDIMSCILQNYNRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKAD 172

  Fly   163 LLSPHTESVMESILSGNYGLLRVLSQVYEVAPEAVTPHAPLLMPLLPQCDPQERMAVFQ-LYLLI 226
            ||:.|||.:::|||.||..|||||..|||..|:.:..|...|:.|:.|.:..|:..:.: |::..
Human   173 LLADHTEVIVKSILQGNTMLLRVLPAVYEKQPQPINRHLTELLALMSQLEQPEQYHLLRLLHVAA 237

  Fly   227 VQKSPEVLESCVPQLCGSLLDSDTSSITMQILLKLSQHSPSLLVDHFEQLRLAAKTNPGTIPLCA 291
            .:|..||::.|:|.|.|.|.||..:.|.:.||::::.:.|..|......|:...:..|......|
Human   238 KKKQLEVVQKCIPFLIGHLKDSTHNDIILNILIEIAVYEPVALNSFLPMLKEIGERFPYLTGQMA 302

  Fly   292 QIMTTAGIGSKETAQQALDFVLEHLPTQA-----LLQQEATRLCSAYPVLFTDKVLACVRQKNAA 351
            :|....|...:|.|:..|.:::..|....     :|..|...:...:..:...:.....|..|:.
Human   303 RIYGAVGHVDEERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSF 367

  Fly   352 LSSQQDVGNGLANKTSGGVTIVSLNSSSPSPPLKPVPVGAPAINTTIVQPASV----VSATPTPP 412
            .:..:.:...|.|..:|.                    |...|:|.|..|..:    :..|....
Human   368 TAIAKLLTRQLENTKAGS--------------------GRRKISTEIEFPEKLEETKLIVTENED 412

  Fly   413 PSSASAPI-ASSTPVSAATPTPQHAGYTRRVKLGDSRSTGRLHPASNTHRSVTRLNVASGSVGGL 476
            .......| |....::|.:.||   |..||..||......|.:...|..:|:           ..
Human   413 HEKLQVKIQAFEDKINAGSNTP---GSIRRYSLGQVSKEERKNIRFNRSKSL-----------AF 463

  Fly   477 HKSMTRLSNSQINQQPG-GSSNGNVVVQSGATPKTPTGLSNPPVTPVPPLSNNVVITGHNRHGIP 540
            |..:|:          | ||.:|.                                 ..||..||
Human   464 HTMLTK----------GVGSDDGE---------------------------------DENRGDIP 485

  Fly   541 VTSGGVTVTTSPSKVRPHSQGPSTLLNSSTVLMKYSTDALNQSVG--SISIPQSAAVATLPSTQT 603
                   .:.|.|::.|..||...|        .:.||.....:|  |:|.|
Human   486 -------ASISLSEIDPLGQGNDKL--------PFKTDTERSQLGESSVSYP------------- 522

  Fly   604 QNAVSVHHASPALPQSASNGHAKSVMKLPVNGNSEVIVSGPTTNVAPRRSDNTSRTLLNANSVMD 668
                                                       |:....|:|.|.| :..||..:
Human   523 -------------------------------------------NIIHIDSENLSET-VKENSQEE 543

  Fly   669 QRMSTFEPYQIMRDPVQQFCEKNFNSIKSYMDEVSQHLPPPTRCSIEVSNEFAERRTKKVAKLHF 733
            ...:|..|.: .:|.:....:||.:.:|:|..|:.:.:|.|.:|:||      :.....||||.|
Human   544 TPETTASPIE-YQDKLYLHLKKNLSKVKAYAMEIGKKIPVPDQCTIE------DTVRSCVAKLFF 601

  Fly   734 ACQIRGPHCLYSKTCFTMRTRNPKTWIHMMFLDFQVRHFVKEKCVLSTRESGISNLKNIWQILKC 798
            .|.::|.:|||||:.|.:.::.|:.||.:||| ||...|.:.   ||.:...:..|:.:|:..:.
Human   602 TCSLKGHYCLYSKSSFILISQEPQPWIQIMFL-FQQSLFPEP---LSIQSHSVQFLRALWEKTQA 662

  Fly   799 EN-RSF-TELVTSQFPQVKDREILVNELRHSGFLDVFEVSKTDKSNPNCNELEYQWGCFLCNHPD 861
            .. .|| |.::.|.|||.||.:.:...|....|.|||..|:|..:          |.||:||:|:
Human   663 GGAHSFETAMMESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGA----------WQCFMCNNPE 717

  Fly   862 KAVGFLNGSNQPMIEGQLKEKKGKWRLFRRWRTRYFTLSGAHLSC-KGSSGGE----SIDVNQIR 921
            ||. .:|...||:|||:||||:.:|:..:||:||||||:|..|.. ||.|..:    .|::::::
Human   718 KAT-VVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQ 781

  Fly   922 SVKV---SRGARNIPKAFEIFTADQTLILKPKDGKNAEEWVQCLSIVVAHSQARDNPTAKT 979
            |||.   .|..|::|:||||||.::|.:.|.||.||||||:||:::.||.::.|::....|
Human   782 SVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAEEWLQCINVAVAQAKERESREVTT 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
melt	NP_523953.2	PH_MELT_VEPH1	872..972	CDD:269965	50/107 (47%)
melt	NP_523953.2	PH	873..967	CDD:278594	47/101 (47%)
VEPH1	XP_011511436.1	PH_MELT_VEPH1	727..835	CDD:269965	50/107 (47%)
VEPH1	XP_011511436.1	PH	728..830	CDD:278594	47/101 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149693
Domainoid	1	1.000	356	1.000	Domainoid score	I985
eggNOG	1	0.900	-	-		E1_KOG3723
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11624
Inparanoid	1	1.050	451	1.000	Inparanoid score	I1608
Isobase	1	0.950	-	0	Normalized mean entropy	S7287
OMA	1	1.010	-	-		QHG46394
OrthoDB	1	1.010	-	-		D139521at2759
OrthoFinder	1	1.000	-	-		FOG0007078
OrthoInspector	1	1.000	-	-		oto91809
orthoMCL	1	0.900	-	-		OOG6_108321
Panther	1	1.100	-	-	LDO	PTHR21630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720