DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment melt and Veph1

DIOPT Version :9

Sequence 1:	NP_523953.2	Gene:	melt / 38785	FlyBaseID:	FBgn0023001	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	XP_006502205.1	Gene:	Veph1 / 72789	MGIID:	1920039	Length:	867	Species:	Mus musculus

Alignment Length:	1017	Identity:	320/1017 - (31%)
Similarity:	482/1017 - (47%)	Gaps:	224/1017 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHELFNKVLAKRDLSRAGDLFSVPDADIVDDITEVLSEISPIISHADYVKNNNDQSVVEICVTRV 65
            ||:||..||.::|||:||||||:.||:|.|.:||.|.:|..|.|..||..|||||:|||||:||:
Mouse    35 MHQLFRLVLGQKDLSKAGDLFSLDDAEIEDSLTEALEQIKVISSSLDYQTNNNDQAVVEICITRI 99

  Fly    66 LSCIRETKTAERYCAALVDLLRTCLLWNLQPSGTTKEEPPHAKIAADIISSIFLNYDKKELMKIA 130
            .:.||||::.|::..|||.|..:||..||:|:| ..|:.||||||:||:|.|..||::..:|.:|
Mouse   100 TTAIRETESIEKHARALVGLWDSCLEHNLRPAG-KDEDTPHAKIASDIMSCILQNYNRTPVMVLA 163

  Fly   131 LPVAVQFLPKGNRELSRNLASYLSLAAIDHAGLLSPHTESVMESILSGNYGLLRVLSQVYEVAPE 195
            :|:||:||.:|::||.||:::|||||||..|.||:.|||.:::|||.||..|||||..|||..|:
Mouse   164 VPIAVKFLHRGSKELCRNMSNYLSLAAITKADLLADHTEGIIKSILQGNAMLLRVLPAVYEKQPQ 228

  Fly   196 AVTPHAPLLMPLLPQCDPQERMAVFQ-LYLLIVQKSPEVLESCVPQLCGSLLDSDTSSITMQILL 259
            .:..|...|:.|:.|.:..|:..:.: |::...:|..||::.|||.|..:|.||..:.|.:.||:
Mouse   229 PINRHLAELLALMSQLEQTEQYHLLRLLHVAAKRKDVEVVQKCVPFLIRNLKDSTYNDIILNILI 293

  Fly   260 KLSQHSPSLLVDHFEQLRLAAKTNPGTIPLCAQIMTTAGIGSKETAQQALDFVLEHL-----PTQ 319
            :::.|.|..|......|:..|:..|......|:|....|...:|.|:..|.:::..|     |..
Mouse   294 EIAGHEPLALNSFLPMLKEIAEQFPYLTGQMARIFGAVGHVDEERARSCLRYLVSQLANMEHPFH 358

  Fly   320 ALLQQEATRLCSAYPVLFTDKVLACVRQKN-----AALSSQQDVGNGLAN----KTSGGVTIV-- 373
            .:|..|...:..|:..:.........|..|     |.|.|:| :.|..|:    |||..|:|.
Mouse   359 HILLLEIKSITDAFSSILGPHSRDIFRMSNSFTNIAKLLSRQ-LENSKADSSRRKTSTEVSIPEK 422

  Fly   374 --SLNSSSP-SPPLKPVPVGAPAINTTIVQPASVVSATPTPPPSSASAPIASSTPVSAATPTPQH 435
              .|||..| |...:.:.|...|....|                            :|.:.||
Mouse   423 LRELNSMEPESEDHEKLQVKIQAFEDKI----------------------------NAESNTP-- 457

  Fly   436 AGYTRRVKLGDSRSTGRLHPASNTHRSVTRLNVASGSVGGLHKSMTRLSNSQINQQPGGSSNGNV 500
             |..||..|.        |.:....:|:                  |.|.|:
Mouse   458 -GSGRRYSLD--------HISKEERKSI------------------RFSRSR------------- 482

  Fly   501 VVQSGATPKTPTGLSNPPVTPVPPLSNNVVITGHNRHGIPV------TSGGVTVTTSPSKVRPHS 559
                                   .|:.|.|:|    :|:.|      ...|:..:.|.|::.|.|
Mouse   483 -----------------------SLALNTVLT----NGVSVEDNEVEEKAGMHASISLSQIDPLS 520

  Fly   560 QGPSTLLNSSTVLMKYSTDALNQSVGSISIPQSAAVATLPSTQTQNAVSVHHASPALPQSASNGH 624
            .|...|        .:.||.                               |.||....|||
Mouse   521 HGIGKL--------PFKTDT-------------------------------HGSPLRNSSAS--- 543

  Fly   625 AKSVMKLPVNGNSEVIVSGPTTNVAPRRSDNTSRTLLNANSVMDQRMSTFEPYQIMRDPVQQFCE 689
                       :..:|.:.|.| :.....:|....:|.|.:      |..| ||   |.:.....
Mouse   544 -----------HPSIIHTEPET-MPETFKENIQEEILEAAT------SPIE-YQ---DKLYLHLR 586

  Fly   690 KNFNSIKSYMDEVSQHLPPPTRCSIEVSNEFAERRTKKVAKLHFACQIRGPHCLYSKTCFTMRTR 754
            :|.:.:|:|..|:::.:|.|.:|:||      :.....||||.|.|.::|.:|||||:.|.:.::
Mouse   587 ENLSKVKAYALEIAKKVPIPDQCTIE------DTMRSCVAKLFFTCSLKGHYCLYSKSSFILVSQ 645

  Fly   755 NPKTWIHMMFLDFQVRHFVKEKCVLSTRESGISNLKNIWQILKCEN---RSFTELVT-SQFPQVK 815
            .|:.||.:|||..|  ....|.  ||.:...:..||.:|:  |.::   .||...:| |.|||.|
Mouse   646 APQPWIQVMFLSQQ--SLFPEP--LSIQSGSVQFLKALWE--KTQDTGAHSFEVAMTESTFPQQK 704

  Fly   816 DREILVNELRHSGFLDVFEVSKTDKSNPNCNELEYQWGCFLCNHPDKAVGFLNGSNQPMIEGQLK 880
            |.|.|...|....|.|||..|:|..:          |.||:||:|:||. .:|...||:|||:||
Mouse   705 DLEQLQLHLEEVRFFDVFGFSETAGA----------WQCFMCNNPEKAT-VVNQDGQPLIEGKLK 758

  Fly   881 EKKGKWRLFRRWRTRYFTLSGAHLSC-KGSSGGE----SIDVNQIRSVKV---SRGARNIPKAFE 937
            ||:.:|:..:||:|.||||:|..|.. ||.|..:    .|::::::|||.   .|..|::|:|||
Mouse   759 EKQVRWKFIKRWKTHYFTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKAVAKKRRDRSLPRAFE 823

  Fly   938 IFTADQTLILKPKDGKNAEEWVQCLSIVVAHSQARDNPTAKT 979
            |||..:|.:.|.||.||||||:||:::.:|.::.|::....|
Mouse   824 IFTDSKTYVFKAKDEKNAEEWLQCINVALAQAKERESREVTT 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
melt	NP_523953.2	PH_MELT_VEPH1	872..972	CDD:269965	48/107 (45%)
melt	NP_523953.2	PH	873..967	CDD:278594	46/101 (46%)
Veph1	XP_006502205.1	PH_MELT_VEPH1	750..858	CDD:269965	48/107 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839744
Domainoid	1	1.000	352	1.000	Domainoid score	I1009
eggNOG	1	0.900	-	-		E1_KOG3723
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11624
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1632
Isobase	1	0.950	-	0	Normalized mean entropy	S7287
OMA	1	1.010	-	-		QHG46394
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007078
OrthoInspector	1	1.000	-	-		oto95385
orthoMCL	1	0.900	-	-		OOG6_108321
Panther	1	1.100	-	-	LDO	PTHR21630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4653
SonicParanoid	1	1.000	-	-		X5168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740