DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment melt and veph1

DIOPT Version :9

Sequence 1:	NP_523953.2	Gene:	melt / 38785	FlyBaseID:	FBgn0023001	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_997996.1	Gene:	veph1 / 405756	ZFINID:	ZDB-GENE-041014-375	Length:	813	Species:	Danio rerio

Alignment Length:	1015	Identity:	308/1015 - (30%)
Similarity:	462/1015 - (45%)	Gaps:	240/1015 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHELFNKVLAKRDLSRAGDLFSVPDADIVDDITEVLSEISPIISHADYVKNNNDQSVVEICVTRV 65
            ||:||..||.:|||||||||||:.|::|.|.:::.|.||..|....||:.|:|||:|||||:||:
Zfish     1 MHQLFRLVLGQRDLSRAGDLFSLDDSEIEDCLSQALEEIKVISCSPDYLTNDNDQAVVEICITRI 65

  Fly    66 LSCIRETKTAERYCAALVDLLRTCLLWNLQPSGTTKEEPPHAKIAADIISSIFLNYDKKELMKIA 130
            .:.||||.:.||:.||||.|..:||..||||.| ..|:.||||||:||.|.|..||::..:|.:|
Zfish    66 TTAIRETGSIERHGAALVSLWESCLEHNLQPQG-KDEDTPHAKIASDITSCILQNYNRPPVMALA 129

  Fly   131 LPVAVQFLPKGNRELSRNLASYLSLAAIDHAGLLSPHTESVMESILSGNYGLLRVLSQVYEVAPE 195
            :||||:||.:||:|||||::||||||||..|.||:.|||::..|:|:||..|||||..||...||
Zfish   130 VPVAVRFLQQGNQELSRNMSSYLSLAAIAKAELLAQHTEAITCSVLAGNTMLLRVLPSVYPRQPE 194

  Fly   196 AVTPHAPLLMPLLPQCDPQERMAVFQLYLLIVQKSPEVLESCVPQLCGSLLDSDTSSITMQILLK 260
            .:..|...|..::|:.|...|..:.:|..:|....|.||.|.||.|.|.|.|||.....:.:|:.
Zfish   195 PIHQHVRELTAMMPRLDQTGRQHLLRLLQMISDLHPLVLSSLVPLLIGFLGDSDLGDSALGVLVN 259

  Fly   261 LSQHSPSLLVDHFEQLRLAAKTNPGTIPLCAQIMTTAGIGSKETAQQALDFVLEHLPTQALLQQE 325
            ::|.||..|......||...:.||..:...|:|....|:.|:..|:.||.:::..|
Zfish   260 VAQSSPVSLAPFLSTLRNVGQKNPWLLGHIAKIHRAVGLTSEIQARGALQYLVSLL--------- 315

  Fly   326 ATRLCSAYPVLFTDKVLACVRQKNAALSSQQDVGNGLANKTSGGVTIVSL-NSSSPSPPLKPVPV 389
            |:...||:..|..:  :.|:..:..::..            .||..|..: ||.|....|....:
Zfish   316 ASMEHSAHHTLLLE--IRCLTDRYTSILG------------GGGKDIYRMSNSFSAIARLLGRKL 366

  Fly   390 GAPAINTTIVQPASVVSATPTPPPSSASAPIAS---------------------STPVSAATPTP 433
            .|   :..:.:....|...|.|..:.:.:.:.:                     .:.|..|:|.|
Zfish   367 EA---DGAVSRGEEKVQDLPRPHEAESGSEMFAENQHLQVKIQAFEEKIGDEEVESEVDGASPGP 428

  Fly   434 QHAGYTRRVKLGDSRSTGRLHPASNTHRSVTRLNVASGSVGGLHKSMTRLSNSQINQQPGGSSNG 498
            |     ||..||.:....|.....|..:|:           .||...||..||.
Zfish   429 Q-----RRHSLGQAARDERREMRFNRSKSL-----------ALHAVRTRSINSD----------- 466

  Fly   499 NVVVQSGATPKTPTGLSNPPVTPVPPLSNNVVITGHNRHGIPVTSGGVTVTTSPSKVRPHSQGPS 563
                                                               :||       :|..
Zfish   467 ---------------------------------------------------SSP-------EGEG 473

  Fly   564 TLLNSSTVLMKYSTDALNQSVGSISIPQSAAVATLPSTQTQNAVSVHHASPALPQSASNGHAKSV 628
            ..||:.          ||     :...::::|::.|...|:
Zfish   474 LDLNAE----------LN-----VCEAETSSVSSTPHNHTE------------------------ 499

  Fly   629 MKLPVNGNSEVIVSGPTTNVAPRRSDNTSRTLLNANSVMDQRMSTFEPYQIMRDPVQQFCEKNFN 693
                            .|...|..|.||.          ..::...:|.:  ||.:......|..
Zfish   500 ----------------LTETQPDTSPNTE----------GAKVEDGDPRE--RDRLWIHLRDNME 536

  Fly   694 SIKSYMDEVSQHLPPPTRCSIEVSNEFAERRTKKVAKLHFACQIRGPHCLYSKTCFTMRTRNPKT 758
            .|||:..|:.:.:|.|..|.||.|:...      ||||.|:|.::|.:|||.|:.|::.:..|..
Zfish   537 EIKSFCAEMIKQIPVPEHCVIEDSHRGC------VAKLSFSCPLKGHYCLYGKSSFSLCSSQPHL 595

  Fly   759 WIHMMFLDFQVRH----FVKEKCVLSTRESGISNLKNIWQILKCENRSFTELVTSQ--FPQVKDR 817
            ||.:|.|..|.:.    ..:::|||        .|:.:|:..:.......||..:|  .|..||.
Zfish   596 WIQIMLLALQSKASEALCCQDECVL--------QLRKLWEKTQLTGAHSFELAMTQTTVPHKKDV 652

  Fly   818 EILVNELRHSGFLDVFEVSKTDKSNPNCNELEYQWGCFLCNHPDKAVGFLNGSNQPMIEGQLKEK 882
            :.|...|....|.|:|..|: ||..         |.||:|::|:||. .:|...||:|||:||||
Zfish   653 DSLQMYLEDVRFFDLFSYSE-DKGG---------WLCFMCSNPEKAT-VVNQDGQPLIEGKLKEK 706

  Fly   883 KGKWRLFRRWRTRYFTLSGAHLSC-KGSSGGE----SIDVNQIRSVKV---SRGARNIPKAFEIF 939
            :.:|:..:||:||||||:|..|.. :|.|..|    :|::::::||||   .|..|.:|:|||||
Zfish   707 QVRWKFIKRWKTRYFTLAGNQLLFRRGKSKDELDNNTIELSKVQSVKVVAKKRRDRGLPRAFEIF 771

  Fly   940 TADQTLILKPKDGKNAEEWVQCLSIVVAHSQARDNPTAKT 979
            |..:|.:||.:|.|:||||:||:::.||.::.|:|..|.|
Zfish   772 TDSKTYVLKAQDEKHAEEWLQCINVAVAQAKERENREATT 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
melt	NP_523953.2	PH_MELT_VEPH1	872..972	CDD:269965	50/107 (47%)
melt	NP_523953.2	PH	873..967	CDD:278594	47/101 (47%)
veph1	NP_997996.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..445		10/35 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..522		8/87 (9%)
		PH_MELT_VEPH1	696..804	CDD:269965	50/107 (47%)
		PH	697..799	CDD:278594	47/101 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583827
Domainoid	1	1.000	348	1.000	Domainoid score	I999
eggNOG	1	0.900	-	-		E1_KOG3723
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11624
Inparanoid	1	1.050	445	1.000	Inparanoid score	I1610
OMA	1	1.010	-	-		QHG46394
OrthoDB	1	1.010	-	-		D139521at2759
OrthoFinder	1	1.000	-	-		FOG0007078
OrthoInspector	1	1.000	-	-		oto39746
orthoMCL	1	0.900	-	-		OOG6_108321
Panther	1	1.100	-	-	LDO	PTHR21630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4653
SonicParanoid	1	1.000	-	-		X5168
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800