Protein Alignment melt and Veph1

DIOPT Version :10

• Sequence 1: NP_523953.2
• Gene: melt / 38785
• FlyBaseID: FBgn0023001
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: XP_008759273.1
• Gene: Veph1 / 361954
• RGDID: 1308217
• Length: 833
• Species: Rattus norvegicus
• Alignment Length: 1019
• Identity: 318/1019 - (31%)
• Similarity: 479/1019 - (47%)
• Gaps: 228/1019 - (22%)

  Fly     1 MHELFNKVLAKRDLSRAGDLFSVPDADIVDDITEVLSEISPIISHADYVKNNNDQSVVEICVTRV 65
            ||:||..||.::||||||||||:.||:|.|.:||.|.:|..|.|..||..|||||:|||||:||:
  Rat     1 MHQLFRLVLGQKDLSRAGDLFSLDDAEIEDSLTEALEQIKVISSSLDYQTNNNDQAVVEICITRI 65

  Fly    66 LSCIRETKTAERYCAALVDLLRTCLLWNLQPSGTTKEEPPHAKIAADIISSIFLNYDKKELMKIA 130
            .:.||||::.|::..|||.|..:||..||:|:| ..|:.||||||:||:|.|..||::..:|.:|
  Rat    66 TTAIRETESIEKHARALVGLWDSCLEHNLRPAG-KDEDTPHAKIASDIMSCILQNYNRTPVMVLA 129

  Fly   131 LPVAVQFLPKGNRELSRNLASYLSLAAIDHAGLLSPHTESVMESILSGNYGLLRVLSQVYEVAPE 195
            :|:||:||.:|::||.||:::|||||||..|.||:.|||.:::|||.||..|||||..|||..|:
  Rat   130 VPIAVKFLHRGSKELCRNMSNYLSLAAITKADLLADHTEGIVKSILQGNAMLLRVLPAVYEKQPQ 194

  Fly   196 AVTPHAPLLMPLLPQCDPQERMAVFQ-LYLLIVQKSPEVLESCVPQLCGSLLDSDTSSITMQILL 259
            .:..|...|:.|:.|.:..|:..:.: |::...:|..||::.|||.|..:|.:|..:.|.:.||:
  Rat   195 PINRHLAELLALMSQLEQTEQYHLLRLLHVAAKRKDVEVVQKCVPFLIRNLKESTYNDIILNILI 259

  Fly   260 KLSQHSPSLLVDHFEQLRLAAKTNPGTIPLCAQIMTTAGIGSKETAQQALDFVLEHLPTQA---- 320
            :::.|.|..|......|:..|:..|......|:|....|...:|.|:..|.:::..|....
  Rat   260 EIAGHEPLALNSFLPMLKEIAEQFPYLTGQMARIFGAVGHVDEERARSCLRYLVSQLANMEHSFH 324

  Fly   321 -LLQQEATRLCSAYPVLFTDKVLACVRQKNA------ALSSQQDVGNGLANKTSGGVTIVSLNSS 378
             :|..|...|..|:..:.........|..|:      .||.|.:                  ||.
  Rat   325 HILLLEIKSLTDAFSSILGPHSRDIFRMSNSFTNIAKLLSRQLE------------------NSK 371

  Fly   379 SPSPPLKPVPVGAPAINTTIVQPASVVSATPTPPPSSASAPI-----ASSTPVSAATPTPQHAGY 438
            :.|        |.....|.:..|..........|.|.....:     |....::|.:.||   |.
  Rat   372 AES--------GRRRTGTEVSFPEKFREPKTMEPKSEDHEKLQVKIQAFEDKINAESHTP---GS 425

  Fly   439 TRRVKLGDSRSTGRLHPASNTHRSVTRLNVASGSVG----------GLHKSMTRLSNSQINQQPG 493
            .||..|.......|.:...:..||:....|.:.||.          |:|.|   :|.|:|:
  Rat   426 VRRYSLDHVSKEERKNVRFSRSRSLALNTVLTNSVNVEDGEIEGKTGMHAS---ISLSEID---- 483

  Fly   494 GSSNGNVVVQSGATPKTPTGLSNPPVTPVPPLSNNVVITGHNRHGIPVTSGGVTVTTSPSKVRPH 558
                                         ||           .|||    |.|     |.|...|
  Rat   484 -----------------------------PP-----------GHGI----GKV-----PFKTDTH 499

  Fly   559 SQGPSTLLNSSTVLMKYSTDALNQSVGSISIPQSAAVATLPSTQTQNAVSVHHASPA-LPQSASN 622
            .   |.|.|||                          |:.|        |:.|:.|. :|::...
  Rat   500 G---SQLRNSS--------------------------ASHP--------SIIHSEPENMPETFKE 527

  Fly   623 GHAKSVMKLPVNGNSEVIVSGPTTNVAPRRSDNTSRTLLNANSVMDQRMSTFEPYQIMRDPVQQF 687
                       |...|:    |...::|                        ..||   |.:...
  Rat   528 -----------NVQEEI----PEAAISP------------------------VEYQ---DKLYLH 550

  Fly   688 CEKNFNSIKSYMDEVSQHLPPPTRCSIEVSNEFAERRTKKVAKLHFACQIRGPHCLYSKTCFTMR 752
            .::|.:.:|:|..|:::.:|.|.:|:||      :.....||||.|.|.::|.:|||||:.||:.
  Rat   551 LKENLSKVKAYALEIAKKVPIPDQCTIE------DNTRSCVAKLFFTCSLKGHYCLYSKSSFTLV 609

  Fly   753 TRNPKTWIHMMFLDFQVRHFVKEKCVLSTRESGISNLKNIWQILKCE---NRSFTELVT-SQFPQ 813
            ::.|:.||.:||| ||...|.:.   ||.:...:..||.:|:  |.:   ..||...:| |.|||
  Rat   610 SQAPQPWIQIMFL-FQQSLFPEP---LSIQSGSVQFLKALWE--KTQGTGTHSFEVAMTESTFPQ 668

  Fly   814 VKDREILVNELRHSGFLDVFEVSKTDKSNPNCNELEYQWGCFLCNHPDKAVGFLNGSNQPMIEGQ 878
            .||.:.|...|....|.|||..|:|..:          |.||:||:|:||. .:|...||:|||:
  Rat   669 QKDLDQLQLHLEEVRFFDVFGFSETAGA----------WQCFMCNNPEKAT-VINQDGQPLIEGK 722

  Fly   879 LKEKKGKWRLFRRWRTRYFTLSGAHLSC-KGSSGGE----SIDVNQIRSVKV---SRGARNIPKA 935
            ||||:.:|:..:||:||||||:|..|.. ||.|..:    .|::::::|||.   .|..|::|:|
  Rat   723 LKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKAVAKKRRDRSLPRA 787

  Fly   936 FEIFTADQTLILKPKDGKNAEEWVQCLSIVVAHSQARDNPTAKT 979
            |||||.::|.:.|.||.||||||:||:::.:|.::.|::....|
  Rat   788 FEIFTDNKTYVFKAKDEKNAEEWLQCINVALAQAKERESREVTT 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
melt	NP_523953.2	DUF5585	508..>659	CDD:465521	25/151 (17%)
		PH_MELT_VEPH1	872..972	CDD:269965	49/107 (46%)
Veph1	XP_008759273.1	PH_MELT_VEPH1	716..824	CDD:269965	49/107 (46%)