DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment melt and K10B4.3

DIOPT Version :9

Sequence 1:	NP_523953.2	Gene:	melt / 38785	FlyBaseID:	FBgn0023001	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_493664.2	Gene:	K10B4.3 / 173397	WormBaseID:	WBGene00019615	Length:	871	Species:	Caenorhabditis elegans

Alignment Length:	1027	Identity:	288/1027 - (28%)
Similarity:	459/1027 - (44%)	Gaps:	217/1027 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHELFNKVLAKRDLSRAGDLFSVPDADIVDDITEVLSEISPIISHADYVKNNNDQSVVEICVTRV 65
            ||.|.:::|..|.|:.:..||:|...|::.|::...:.:..|::...|..|..|||||||.|.|:
Worm     1 MHFLLSRLLHHRQLNVSAQLFNVSHYDVITDMSNTFTCLKEILNAPSYPSNKVDQSVVEIVVARL 65

  Fly    66 LSCIRETKTAERYCAALVDLLRTCLLWNLQPSGTTKE-----EPPHAKIAADIISSIFLNYDKKE 125
            .:.||||.:.|.|.|.|||:|...|   ..|..|..|     :.||.|||:|::||:||:|..|.
Worm    66 TAAIRETGSIESYAAELVDVLDEVL---RHPMTTLNEKCQDVDSPHCKIASDLLSSLFLHYGNKP 127

  Fly   126 LMKIALPVAVQFLPKGNRELSRNLASYLSLAAIDHAGLLSPHTESVMESILSGNYGLLRVLSQVY 190
            :|.:.:|||::.|...|.||.:|..||:|||||.:...||.|...::.:::.|||.|:|||..:|
Worm   128 VMTLTIPVALKCLNSENGELVKNTTSYISLAAIHNGKSLSSHALQIISNVVRGNYSLIRVLPHIY 192

  Fly   191 EVAPEAVTP-HAPL--LMPLL--PQCDPQERMAVFQLYLLIVQKSPEVLESCVPQLCGSLLDSDT 250
               |:...| ||.|  |:.||  .:.|..|::::.||..::....|:||...:|:....||....
Worm   193 ---PDNKEPFHAQLSQLIDLLQNTEVDCSEKLSLLQLSSMVANTKPDVLIPFLPRFDVYLLSPQM 254

  Fly   251 SSITMQILLKL-SQHSPSLLVDHFEQLRLAAKTNPGTIPLCAQIMTTAGIGSKETAQQALDFVLE 314
            |:..:.|.:.| ||:....|......|:|||::|                          :|:
Worm   255 STALLNIYMSLISQNRTKSLSQFLPTLKLAAQSN--------------------------EFI-- 291

  Fly   315 HLPTQALLQQEATRLCSAYPVLFTDKVLACVRQKNAALSSQQDVGNGLANKTSGGVTIVSLNSSS 379
                     ...|.:|         |::|.:.:          |.:.||::....:.:::.|:||
Worm   292 ---------NNRTTIC---------KIIANIGR----------VSSPLASEAVDELVLMARNNSS 328

  Fly   380 PSPPLKPVPVGAPAINTTIVQPASV---VSATPTPPPSSASAPIASSTPVSAATPTPQHAGYTRR 441
            ....|:.|.....||.:  :.|.|:   ||...|.|                          |.|
Worm   329 DQQILQTVLNEIDAIGS--IHPTSLRRHVSFFQTLP--------------------------TSR 365

  Fly   442 VKLGDSRSTGRLHPASNTHRSVTRLNVASGSVGGLHKSMTRLS-NSQINQQPGGSSNGNVVVQSG 505
            :   ..|....|:|  |...::...::...|...|      || ||::        .||::...|
Worm   366 I---IERILAHLNP--NNSENIMSYDIKEQSTESL------LSKNSKV--------FGNLITSGG 411

  Fly   506 ATPKTPTGLSNPPVTPVPPLSNNVVITGHNRHGIPV------TSGGVTVTTSPSKVRPHS----- 559
               :|...:.:.|...:..|..|.       |.:.:      :||.::..:..|..  ||
Worm   412 ---RTVFEVCDSPTVELCELDRNT-------HSLAMQYQNNRSSGSLSRRSHASIA--HSLGAGT 464

  Fly   560 QGPSTLLNSSTVLMKYSTDALNQSVGSISIPQSAAVATLPSTQTQNAVS-----VHHASPALP-- 617
            .||.:.:|.|            :.:..||:|.|:....|.:..|.::.|     .|..:|...
Worm   465 HGPYSDINES------------RELSMISMPSSSRTNVLLAQPTSSSTSRIQTLPHAFAPQAMTQ 517

  Fly   618 -QSASNGHAKSVMKLPVNGNSEVI--VSGPTTNVAPRRSDNTSRTLLNANSVMDQRMSTFEPYQI 679
             |...:|..:     ||.|....:  .:|.|....|......:.:.:.|.:..|::....:
Worm   518 IQMGKDGRVR-----PVGGGRRPVQWPAGSTETTFPAHLGPITTSKMCALNEEDEKWINND---- 573

  Fly   680 MRDPVQQFCEKNFNSIKSYMDEVSQHLPPPTRCSIEVSNEFAERRTKKVAKLHFACQIR-GPHCL 743
            ..|.|.:|.|...|.|:.|:.||:...|.|.:|::|.|     :.:|....:||:||.| .|.|:
Worm   574 RNDVVYKFVEHRKNKIRRYIGEVNARFPVPVQCTVEGS-----KNSKHRMVIHFSCQTRSSPCCV 633

  Fly   744 YSKT-CFTMRTRNPKTWIHMMFLDFQVRHFVKEKCVLSTRESGISNLKNIWQILKCENRSFTE-- 805
            ::|. .|..:|:.|..|:|.|||..:.....:...|:.........|::.|   ||...|.|:
Worm   634 FTKEYLFAFKTKYPAFWLHFMFLQMECSAITQFGEVVGKDSQQYQTLEHCW---KCLPSSITKSV 695

  Fly   806 ----LVTSQFPQVKDREILVNELRHSGFLDVFEVSKTDKSNPNCNELEYQWGCFLCNHPDKAVGF 866
                ::|:.||..||:..|:.||..:||...|.:..|:.          .|.|..|.:|:|...|
Worm   696 PFDTMITAAFPNSKDQNKLIKELDEAGFFACFTMDSTNN----------MWNCISCTNPEKVKYF 750

  Fly   867 L-NGSNQPMIEGQLKEKKGKWRLFRRWRTRYFTLSGA-------HLSCKGSSGGESIDVNQIRSV 923
            : .|..:.::|||||||||:||..:||.|:|||||.|       |:.....:...|||:..||||
Worm   751 VEEGGAEKVLEGQLKEKKGRWRFLKRWNTKYFTLSSAALNYSTQHMPTDSRALLPSIDLRSIRSV 815

  Fly   924 K-VSRG---ARNIPKAFEIFTADQT-LILKPKDGKNAEEWVQCLSIVVAHSQ 970
            : :.||   .:::.|||||||||.| :|||.||.||||||:.||.|.:||::
Worm   816 RSLGRGKKARKSLRKAFEIFTADNTSMILKAKDEKNAEEWLHCLQIAMAHAR 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
melt	NP_523953.2	PH_MELT_VEPH1	872..972	CDD:269965	56/111 (50%)
melt	NP_523953.2	PH	873..967	CDD:278594	54/105 (51%)
K10B4.3	NP_493664.2	PH-like	757..869	CDD:302622	56/111 (50%)
K10B4.3	NP_493664.2	PH	759..864	CDD:278594	54/104 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161114
Domainoid	1	1.000	258	1.000	Domainoid score	I1080
eggNOG	1	0.900	-	-		E1_KOG3723
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11624
Inparanoid	1	1.050	353	1.000	Inparanoid score	I1321
Isobase	1	0.950	-	0	Normalized mean entropy	S7287
OMA	1	1.010	-	-		QHG46394
OrthoDB	1	1.010	-	-		D139521at2759
OrthoFinder	1	1.000	-	-		FOG0007078
OrthoInspector	1	1.000	-	-		oto18130
orthoMCL	1	0.900	-	-		OOG6_108321
Panther	1	1.100	-	-	LDO	PTHR21630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4653
SonicParanoid	1	1.000	-	-		X5168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750