Protein Alignment melt and melt

DIOPT Version :10

• Sequence 1: NP_523953.2
• Gene: melt / 38785
• FlyBaseID: FBgn0023001
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: XP_061507476.1
• Gene: melt / 1269750
• VectorBaseID: AGAMI1_014930
• Length: 1207
• Species: Anopheles gambiae
• Alignment Length: 1217
• Identity: 552/1217 - (45%)
• Similarity: 700/1217 - (57%)
• Gaps: 291/1217 - (23%)

  Fly     1 MHELFNKVLAKRDLSRAGDLFSVPDADIVDDITEVLSEISPIISHADYVKNNNDQSVVEICVTRV 65
            ||:||..||:||||||||:|||:.|.:||:|:||||.|||.||||.||:.|:|||||:|||:.||
Mosquito     1 MHDLFTTVLSKRDLSRAGELFSIADYEIVNDLTEVLQEISSIISHEDYLHNSNDQSVIEICINRV 65

  Fly    66 LSCIRETKTAERYCAALVDLLRTCLLWNLQPSGTTKE-EPPHAKIAADIISSIFLNYDKKELMKI 129
            .|||::|.|.|::||.||:||.|||.:||||||  || :||||||::||||||||||:|:.:|::
Mosquito    66 TSCIKKTHTIEKHCAGLVNLLETCLRYNLQPSG--KEVDPPHAKISSDIISSIFLNYNKQVVMEV 128

  Fly   130 ALPVAVQFLPKGNRELSRNLASYLSLAAIDHAGLLSPHTESVMESILSGNYGLLRVLSQVYEVAP 194
            .|||||:||.:||.|||||||||||.|||:::.|||||...::||:|.|||||..||||:||..|
Mosquito   129 TLPVAVKFLNQGNLELSRNLASYLSSAAIEYSYLLSPHVHVILESLLGGNYGLCHVLSQIYEATP 193

  Fly   195 EAVTPHAPLLMPLLPQCDPQERMAVFQLYLLIVQKSPEVLESCVPQLCGSLLDSDT-----SSIT 254
            :.:....|..:.::|:|:.||::.:.||.:.|.:..|..|...:|    :||:..|     |:..
Mosquito   194 DPINDAGPKFVEIVPRCELQEQLVILQLLVTIAKLKPSCLTESIP----ALLELATTRPQLSAAA 254

  Fly   255 MQILLKLSQHSPSLLVDHFEQLRLAAKTNPGTIPLCAQIMTTAGIGSKETAQQALDFVLEHL--- 316
            :.:||||::..|..|.::.|..:|.|.|.|.|:...|||::..|...|:.||.|||||||||
Mosquito   255 LLVLLKLAEAKPIKLAEYTEAFKLIAHTVPQTVGFAAQILSAIGRCGKDRAQVALDFVLEHLPRA 319

  Fly   317 --PTQALLQQEATRLCSAYPVLFTDKVLACVRQKNAALSSQQDVGNGLANKTSGGVTIVSLNSSS 379
              |.|.:|..|||:||:.|||||||||.:.|||:....|||      :....|||||||:||||:
Mosquito   320 DRPLQTILLNEATKLCTKYPVLFTDKVTSVVRQRQLTNSSQ------IKQTASGGVTIVNLNSSA 378

  Fly   380 PSPPLKP---------------------VPVGAPA------------------------------ 393
             :|.|.|                     |..|.|.
Mosquito   379 -TPLLPPSTSSAIGTNASSAYSAGVQGSVANGTPTSTVGLQQSGTGVSSSTNYTTSQQGQQQHVL 442

  Fly   394 -----------------------------INTTIVQPASVVSATPTPPPS------------SAS 417
                                         ::||::..::..:.:.|..|:            .:|
Mosquito   443 EHGRAIVSKTPNVAIVSNGHTHTGGSSALMSTTVINTSNGTTLSSTIHPALLTNFMNAANGVPSS 507

  Fly   418 APIASSTPVSAAT----PTPQHAGYTR-RVKLGDSRSTGRLHP-ASNTHRSVTRLNVASGSVGGL 476
            ||..:||.|:..|    |||.|.|||| |.||||||||||||. ....::|.||||.|.||:|||
Mosquito   508 APSGTSTVVNGGTTVVSPTPHHTGYTRNRPKLGDSRSTGRLHSGGGGGNKSTTRLNNAGGSMGGL 572

  Fly   477 HKSMTRLSNSQINQQ-----------------------------PGGSSNGNVVVQS-------- 504
            |||  ||.:||:..|                             .|||::.|:::.|
Mosquito   573 HKS--RLGSSQLINQFNGDIGAGVSIDPEKLTPGVTPNGGPSMVDGGSTSHNIIMHSSNNHHHNH 635

  Fly   505 -------------------GATPKTPTG---LSNPPVTPVPPLSNNVVITGHNRHGIP---VTSG 544
                               |....:.:|   |.|   :..||||.:|.|||.|:.|||   :||.
Mosquito   636 QHHHNHHNSHHSSGNVAIKGMMASSGSGGALLGN---SIPPPLSQHVTITGENKWGIPQTKITSC 697

  Fly   545 GVTVTTSPSKV-RPHSQGPSTLLNSSTVLM--KYSTDALNQSVGSISIPQSAAVATLPSTQTQNA 606
            ||||||||::. ||:|.||...|..||..:  |.|...||||.|||.|
Mosquito   698 GVTVTTSPTRAPRPYSHGPGNTLMGSTGALGGKSSLGGLNQSTGSIGI----------------- 745

  Fly   607 VSVHHASPALPQSASNGHAKSVMKLPV--------NGNSEVIVSGP-TTNVAPR-RSDNTSRTLL 661
             .|||||||.|...:|...::..:|..        :.:::|||||| |....|| .:||.|.|:|
Mosquito   746 -QVHHASPASPTMFNNHSQQTSPQLTTTLSLHSSDDPSNQVIVSGPATVTTRPRGTNDNRSVTIL 809

  Fly   662 NANS-VMDQRMSTFEPYQIMRDPVQQFCEKNFNSIKSYMDEVSQHLPPPTRCSIEVSNEFAERRT 725
            ||:| ....|||.||||. |||.:|.||||:.:.||:|.:.|::.:|||.:|.||      |||.
Mosquito   810 NASSGATTTRMSVFEPYP-MRDTIQHFCEKHLDKIKAYTESVAERIPPPAKCIIE------ERRA 867

  Fly   726 KKVAKLHFACQIRGPHCLYSKTCFTMRTRNPKTWIHMMFLDFQVRHFVKEKCVLSTRESGISNLK 790
            ||:||||||||:||||||||:|.||||||||:||||:||||.|.|   ..|..||:.:..:|.||
Mosquito   868 KKMAKLHFACQVRGPHCLYSRTMFTMRTRNPRTWIHLMFLDLQAR---AGKNALSSWDPSVSRLK 929

  Fly   791 NIWQILKCENRSFTELVTSQFPQVKDREILVNELRHSGFLDVFEV-------------------- 835
            :.|..||||||:|..||||.||..|::|.|||||||:||.||||:
Mosquito   930 HCWDTLKCENRTFITLVTSAFPNGKEQEALVNELRHAGFFDVFEMGPVAVGPGQGGGAGGESAGP 994

  Fly   836 ------------------------------------SKTDKSNPNCNELE-YQWGCFLCNHPDKA 863
                                                :.|..:..:..:|| .|||||||:||:||
Mosquito   995 AAGGPTGGSGAQQSGGVSSPTSGNSGSGGGGGGGGDAGTASNGGSSEDLEVLQWGCFLCHHPEKA 1059

  Fly   864 VGFLNGSNQPMIEGQLKEKKGKWRLFRRWRTRYFTLSGAHLSCKGS---SGGESIDVNQIRSVKV 925
            :|||:|:|||:|||||||||||||||||||||||||||||||||||   :|||||||||||||||
Mosquito  1060 IGFLHGNNQPVIEGQLKEKKGKWRLFRRWRTRYFTLSGAHLSCKGSVSEAGGESIDVNQIRSVKV 1124

  Fly   926 SRGARNIPKAFEIFTADQTLILKPKDGKNAEEWVQCLSIVVAHSQAR 972
            |||||||||||||||.|||||||||||..|||||||||||:||||.|
Mosquito  1125 SRGARNIPKAFEIFTGDQTLILKPKDGNKAEEWVQCLSIVLAHSQVR 1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
melt	NP_523953.2	DUF5585	508..>659	CDD:465521	65/169 (38%)
		PH_MELT_VEPH1	872..972	CDD:269965	93/102 (91%)
melt	XP_061507476.1	None