Protein Alignment msl-3 and ARID4A

DIOPT Version :10

• Sequence 1: NP_523951.1
• Gene: msl-3 / 38779
• FlyBaseID: FBgn0002775
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: XP_005268021.1
• Gene: ARID4A / 5926
• HGNCID: 9885
• Length: 1277
• Species: Homo sapiens
• Alignment Length: 451
• Identity: 75/451 - (16%)
• Similarity: 153/451 - (33%)
• Gaps: 129/451 - (28%)

  Fly    25 SKARVLY----TSKVLNVFERRNEHGLRFYEYKIHFQGWRPSYDRCVRATVLL------------ 73
            :|.:|.|    |.|:.....:..|.......|.:|:.||...||..|:|..::
Human   577 TKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQ 641

  Fly    74 -------KDTE--ENRQLQRELAEAAKLQIRGDYSYK---GTPDKPSAKKKRGGKAAHVEEPIVV 126
                   :|:|  |.|..:|:.::..:..::...|..   |.....:::.|.|.::|....|...
Human   642 KKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSGTRSARSNIPDSS 706

  Fly   127 PMDTGHLEAEHEMAPTPRAAGNRTRDNSGGKRKEKPPSGDGRLKGNRGRQTETFYNNAIND---- 187
            |:..|                  ..|:.....:.:.......:......:.|...|..:||
Human   707 PLSNG------------------MEDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLD 753

  Fly   188 ---VSVYNHVPQE-DRIMMRVSERLRELIEYDRNMIKVLGKQHALPARVPIVTIMENF--VKQQA 246
               ..:..|:.:| ||..|:..|.|:..:..:..::::.|.:            ||..  ||::|
Human   754 EENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNK------------MEKTEEVKKEA 806

  Fly   247 VELAISIKQDSSRARNTQSRNARMEREYDRVMSTVCMLKEVVDGLRIYF-------EFHVDDH-- 302
                    :.|.:.:..:|:...:..|..::.|               |       |.|::.|
Human   807 --------EKSPKGKGRRSKTKDLSLEIIKISS---------------FGQNEAGSEPHIEAHSL 848

  Fly   303 -LLYTEEKEYVHNYLTDDNMRNCSLILNKSYEYINPSGDTELI----GLDGTPVV--EGSGDTNG 360
             |...:.|.:  :..|:|.:..|........:.:..|...:.|    |::.|..|  |.:.|..|
Human   849 ELSSLDNKNF--SSATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIG 911

  Fly   361 QIGVINI-----------GGPEYEKQLQKCLLYIVTASGKNTAQAYERTSPYTAAYKLPVE 410
            ..|:.|:           |.|....:..:|:..:       |::.::  ||......:|::
Human   912 SEGMKNLNFEQHFERENEGMPSLIAESNQCIQQL-------TSERFD--SPAEETVNIPLK 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msl-3	NP_523951.1	CD_CSD	15..81	CDD:475127	17/80 (21%)
		MRG	196..490	CDD:461721	42/245 (17%)
ARID4A	XP_005268021.1	Tudor_ARID4A_rpt1	4..61	CDD:410530
		Tudor_ARID4_rpt2	62..114	CDD:410461
		RBB1NT	170..262	CDD:462390
		ARID_ARID4A	311..397	CDD:350646
		CBD_RBP1_like	577..635	CDD:350843	14/57 (25%)