DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment msl-3 and Arid4a

DIOPT Version :9

Sequence 1:	NP_523951.1	Gene:	msl-3 / 38779	FlyBaseID:	FBgn0002775	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_036013289.1	Gene:	Arid4a / 238247	MGIID:	2444354	Length:	1283	Species:	Mus musculus

Alignment Length:	504	Identity:	97/504 - (19%)
Similarity:	158/504 - (31%)	Gaps:	141/504 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SKARVLY----TSKVLNVFERRNEHGLRFYEYKIHFQGWRPSYDRCVRATVLLKDTEENRQLQRE 85
            :|.:|.|    |.|:.....:..|.......|.:|:.||...||..|:|..::...:
Mouse   580 TKVKVKYGRGKTQKIYEASIKSTEMDDGEILYLVHYYGWNVRYDEWVKADRIIWPLD-------- 636

  Fly    86 LAEAAKLQIRGDYSYKGTPDKPSAKKKRGGKAAHVEEPIVVPMDTGHLEAEHEMAPTPRAAGNRT 150
                           ||.|.|...||.:           ..|....|....|...|.| |..|:.
Mouse   637 ---------------KGGPKKKQKKKVK-----------CQPCLLAHCTLGHAFCPVP-AVENKE 674

  Fly   151 RDNSGGKRKEKPPSGDGRLKGNRGRQ--TETFYNNAINDVSVYNHVPQEDRIMMRVSERLRELIE 213
            ......||.|:      |.|..|||.  ..||..|....:|..::  .|.:     |:......|
Mouse   675 DSEKDEKRDEE------RQKSKRGRPPLKSTFSPNMPYSLSKTSN--SEGK-----SDSCSSDSE 726

  Fly   214 YDRNMIKVLGKQHALPARVPIVTIMENFVKQQAVELAISIKQDSSRARNTQS--------RNARM 270
            .|..:.|..|.:                      :|:..:|::..:..|...        :...:
Mouse   727 ADDQLEKSSGGE----------------------DLSPDVKEELEKNENAHDDKLDEENPKIVHI 769

  Fly   271 EREYDRVMS--TVCMLKEVVDGLRIYFEFHVDDHLLYTEE-KEYVHNYLTDDNMRNCSLILNKSY 332
            .:|.||..:  :..:..|..|..:|...|  .|.:...|| |:.|.........|:.:..|:...
Mouse   770 SKENDRTQAQPSDTLTVEAGDSDQIVHIF--GDKVDQVEEFKKQVEKSPKGKGRRSKTKDLSLEL 832

  Fly   333 EYINPSGDTELIGLDGTPVVEGSGDTNGQIGVINIGGPEYEKQLQKCLLYIVTASGKNTAQAYER 397
            ..|:|.|..           |...:.:|.:..:.....|       |         ||.:...:.
Mouse   833 IKISPFGQE-----------EAGSEAHGDVHSLEFSSLE-------C---------KNFSSTEDD 870

  Fly   398 TSPYTAAYKLPVEMRGFLNETFKWRLLSAESPPEKSMVFGAPHLVRLMIKMPMFLNASPISNKKL 462
            ..||....||            |.::|..:||.:|         :||...|.|   .:.:|.::.
Mouse   871 IDPYEKEKKL------------KRKILGQQSPEKK---------LRLDNGMEM---TTGVSQERS 911

  Fly   463 EDLLPHLDAFINYLENHREWFDRENFVNSTALPQEDLQRELLDSLDGIA 511
            :|..........::|.|.| .:.|...:.||.|.:.||....:..|..|
Mouse   912 DDGAGAEGMKGAHVEQHFE-TEGEGMPSLTAEPDQGLQELTSEKSDSPA 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msl-3	NP_523951.1	MRG	196..486	CDD:283390	50/300 (17%)
Arid4a	XP_036013289.1	Tudor_ARID4A_rpt1	4..61	CDD:410530
		Tudor_SF	62..118	CDD:413384
		RBB1NT	170..262	CDD:400474
		ARID_ARID4A	312..397	CDD:350646
		CBD_RBP1_like	580..638	CDD:350843	14/80 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3001
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900