Protein Alignment INSC and Insc

DIOPT Version :10

• Sequence 1: NP_001027024.3
• Gene: INSC / 387755
• HGNCID: 33116
• Length: 579
• Species: Homo sapiens
• Sequence 2: NP_001392617.1
• Gene: Insc / 233752
• MGIID: 1917942
• Length: 579
• Species: Mus musculus
• Alignment Length: 579
• Identity: 539/579 - (93%)
• Similarity: 553/579 - (95%)
• Gaps: 0/579 - (0%)

Human     1 MRRPPGNGEAASEGPGGWGLWGVQESRRLCCAGHDRCKQALLQIGINMMALPGGRHLDSVTLPGQ 65
            ||||||:|::..||||.|||||.||||||||.|.|||.||||||||||||||||||||||.|..|
Mouse     1 MRRPPGDGDSTGEGPGNWGLWGAQESRRLCCVGPDRCGQALLQIGINMMALPGGRHLDSVPLQEQ 65

Human    66 RLHLMQVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDAQGDLILAGGPGPGDPLQLLLKRGWV 130
            |||.|||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||
Mouse    66 RLHFMQVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDTQGDLILAGGPGPGDPLQLLLKRGWV 130

Human   131 ISTELRRIGQKLAQDRWARVHSMSVRLTCHARSMVSEYSAVSRNSLKEMGEIEKLLMEKCSELSA 195
            |||||||||||||||||||||||||||||||||||||||.:||.:.:|||:.|||||||||||||
Mouse   131 ISTELRRIGQKLAQDRWARVHSMSVRLTCHARSMVSEYSTISRTASQEMGQAEKLLMEKCSELSA 195

Human   196 VTERCLQVENEHVLKSMKACVSETLSMLGQHFGQLLELALTREVQALVRKIDASDNIYTTESTTG 260
            ||||||||||||||||||||||||||:||:||||||||||||||||||||||.|||||.||||||
Mouse   196 VTERCLQVENEHVLKSMKACVSETLSLLGEHFGQLLELALTREVQALVRKIDTSDNIYITESTTG 260

Human   261 NLFSLTQEGAPLCRIIAKEGGVVALFKVCRQDSFRCLYPQALRTLASICCVEEGVHQLEKVDGVL 325
            |||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|
Mouse   261 NLFGLTQEGAPLCRIIAKEGGVVALFKVCRQDSFRCLYPQALRTLASICCVEEGVHQLEKVDGIL 325

Human   326 CLADILTDNSHSEATRAEAAAVVAQVTSPHLPVTQHLSSFLESMEEIVTALVKLCQEASSGEVFL 390
            ||||||||.||||||||||||||||||||||..||||:||||:||||||||:|||||||||||||
Mouse   326 CLADILTDESHSEATRAEAAAVVAQVTSPHLSFTQHLTSFLENMEEIVTALIKLCQEASSGEVFL 390

Human   391 LASAALANITFFDTMACEMLLQLNAIRVLLEACSDKQRVDTPYTRDQIVTILANMSVLEQCASDI 455
            |||||||||||||.|||||||||||||||||||.|||||||||||||||||||||||||||.|||
Mouse   391 LASAALANITFFDKMACEMLLQLNAIRVLLEACGDKQRVDTPYTRDQIVTILANMSVLEQCGSDI 455

Human   456 IQENGVQLIMGMLSEKPRSGTPAEVAACERVQQKAAVTLARLSRDPDVAREAVRLSCMSRLIELC 520
            ||||||||||||||||||||||||||||||||||||||||||.||||||:|||||||||||||||
Mouse   456 IQENGVQLIMGMLSEKPRSGTPAEVAACERVQQKAAVTLARLCRDPDVAQEAVRLSCMSRLIELC 520

Human   521 RSPSERNSSDAVLVACLAALRRLAGVCPEGLQDSDFQQLVQPRLVDSFLLCSNMEESFV 579
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 RSPSERNSSDAVLVACLAALRRLAGVCPEGLQDSDFQQLVQPRLVDSFLLCSNMEESFV 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INSC	NP_001027024.3	INSC_LBD	70..116	CDD:465257	44/45 (98%)
		Important for interaction with GPSM2. /evidence=ECO:0000269|PubMed:22074847	74..89		14/14 (100%)
		Insc_C	127..579	CDD:466076	426/451 (94%)
		PDZ-binding	576..579		2/2 (100%)
Insc	NP_001392617.1	INSC_LBD	70..116	CDD:465257	44/45 (98%)
		Important for interaction with GPSM2. /evidence=ECO:0000269|PubMed:21816348	74..89		14/14 (100%)
		Insc_C	127..579	CDD:466076	426/451 (94%)
		PDZ-binding	576..579		2/2 (100%)