Protein Alignment CG8641 and RASD2

DIOPT Version :10

• Sequence 1: NP_648073.1
• Gene: CG8641 / 38771
• FlyBaseID: FBgn0035733
• Length: 434
• Species: Drosophila melanogaster
• Sequence 2: NP_055125.2
• Gene: RASD2 / 23551
• HGNCID: 18229
• Length: 266
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 131/269 - (48%)
• Similarity: 180/269 - (66%)
• Gaps: 26/269 - (9%)

  Fly   156 CDDSLPSAKNCYRLVMLGSSRAGKSSIVARFLGNRFEEAYTPTIEEFHRKLYRIRNEVFQLDILD 220
            |..|:| |||.||:|:||:||.||||||:|||..|||:.||||||:||||:|.||.:::||||||
Human    10 CTLSVP-AKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVYNIRGDMYQLDILD 73

  Fly   221 TSGYHPFPAMRRLSFLTGDLFILVFSMDSRESFEEVVRLRENILETKWAALNPGSGFKKKSLPKI 285
            |||.||||||||||.||||:||||||:|:||||:||.||::.|||.|....|     |.|...::
Human    74 TSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSCLKN-----KTKEAAEL 133

  Fly   286 PMILAGNKCDRD--FKTVQVDEVMGYIAGQDNCCTFVECSARQNYRIDDLFHSLFTVSNLPLEMT 348
            ||::.|||.|..  .:.|...|....::|.:||..| |.||::|..:|::|:.||:::.||.||:
Human   134 PMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYF-EVSAKKNTNVDEMFYVLFSMAKLPHEMS 197

  Fly   349 PNHHRRLVSVFG-APSPLPPHGSAVGGTKKNALSIKR-RFSDACGVVTPNARRPSIRTDLNLMRS 411
            |..||::...:| |..|.|             ..::| :..||.|:|:|.|||||:.:||..:::
Human   198 PALHRKISVQYGDAFHPRP-------------FCMRRVKEMDAYGMVSPFARRPSVNSDLKYIKA 249

  Fly   412 KTMALNEGE 420
            |  .|.||:
Human   250 K--VLREGQ 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8641	NP_648073.1	Rhes_like	167..434	CDD:133343	125/258 (48%)
RASD2	NP_055125.2	Rhes_like	20..266	CDD:133343	125/258 (48%)
		Effector region	48..56		6/7 (86%)
		Interaction with GNB1, GNB2 and GNB3. /evidence=ECO:0000269|PubMed:19255495	189..235		17/58 (29%)