Protein Alignment Mp and COL27A1

DIOPT Version :10

• Sequence 1: NP_001246651.1
• Gene: Mp / 38769
• FlyBaseID: FBgn0260660
• Length: 1039
• Species: Drosophila melanogaster
• Sequence 2: NP_116277.2
• Gene: COL27A1 / 85301
• HGNCID: 22986
• Length: 1860
• Species: Homo sapiens
• Alignment Length: 783
• Identity: 231/783 - (29%)
• Similarity: 282/783 - (36%)
• Gaps: 280/783 - (35%)

  Fly   222 YGNPDAINVTCMP-PPKAT-------IAPTTADDGSIFYEG----SGENILFEDSTEANILSDDF 274
            ||||.      :| ||.|.       ::|..|.||:....|    ||
Human   660 YGNPG------LPGPPGAKGQKGDPGLSPGKAHDGAKGDMGLPGLSG------------------ 700

  Fly   275 WNTGDEATDIFDASGMQPPGQTQYTHERPYRGIKGEKGERGPKGD-------SIRGPPGPPGPPG 332
             |.|             |||:..:.......|..||:|:.||:|.       ..:|.|||.|.||
Human   701 -NPG-------------PPGRKGHKGYPGPAGHPGEQGQPGPEGSPGAKGYPGRQGLPGPVGDPG 751

  Fly   333 PKGETAPYPPFVETTSAGAKYTGECTCNASDILEAI-----KDNESLRESLRGAPGTPGKDGK-- 390
            |||            |.|  |.|         |..:     .|.|      ||.||.|||.||
Human   752 PKG------------SRG--YIG---------LPGLFGLPGSDGE------RGLPGVPGKRGKMG 787

  Fly   391 ----------------------------PGTPGHTGATGV---------------------PGAR 406
                                        ||.||..|..||                     ||.:
Human   788 MPGFPGVFGERGPPGLDGNPGELGLPGPPGVPGLIGDLGVLGPIGYPGPKGMKGLMGSVGEPGLK 852

  Fly   407 GARGSEGAQGLKGEP---------GVDGLPGVMGPPGP------------PGPPGLPENYDESLM 450
            |.:|.:|..|:.|:|         |:.|.||..|.|||            ||||| ||.:...:.
Human   853 GDKGEQGVPGVSGDPGFQGDKGSQGLPGFPGARGKPGPLGKVGDKGSIGFPGPPG-PEGFPGDIG 916

  Fly   451 V---NSMGAFRGTTQPGAKGVPGEKGDAGQKGER---GDPGHKGAHGPSGAKGEPGEPGTPGLPG 509
            .   |.....:|  :|||:|:||.:|..|.:|:.   |.||..|..|..|.||.||.||..|:.|
Human   917 PPGDNGPEGMKG--KPGARGLPGPRGQLGPEGDEGPMGPPGAPGLEGQPGRKGFPGRPGLDGVKG 979

  Fly   510 LPGQVGQPG--GLDGLASANGTKGEKGEKGEKGMRGRRGGTGATGP------------IGPPGKP 560
            .||..|:||  |..|.....|..||.|..||||.||..|..|..||            :|.||:|
Human   980 EPGDPGRPGPVGEQGFMGFIGLVGEPGIVGEKGDRGMMGPPGVPGPKGSMGHPGMPGGMGTPGEP 1044

  Fly   561 GPMGDIGHSGRPGMTGPKGEMGPKGPKGDSG--GREGLKGDKGDRGQDGR--------------- 608
            ||.|..|..|.|||.|.||..||:||.|.:|  |..||||..|.:|:.||
Human  1045 GPQGPPGSRGPPGMRGAKGRRGPRGPDGPAGEQGSRGLKGPPGPQGRPGRPGQQGVAGERGHLGS 1109

  Fly   609 ---DGLPGPPGLPSTGGGDGDSGGVQYIPMPGPPGPPGPPGLPGLSISGPK------GEPGVDSR 664
               .|:|||.|.|.|.|..|:         |||.||.||.|.||  ..|||      ||||:...
Human  1110 RGFPGIPGPSGPPGTKGLPGE---------PGPQGPQGPIGPPG--EMGPKGPPGAVGEPGLPGE 1163

  Fly   665 SSFFGDASYYGRPGARSSLDELKALRELQDLRD-----RPDGTAEPPRQPG----HSHKHEETLG 720
            :...||....|.||.:..:.:    |....|..     .|||.......||    |..|.:|  |
Human  1164 AGMKGDLGPLGTPGEQGLIGQ----RGEPGLEGDSGPMGPDGLKGDRGDPGPDGEHGEKGQE--G 1222

  Fly   721 LVDGEEPYFSASSSNMNMKIVPG--AVTFQNIDEMTKKSALNPPGTLAYITEEEALLVRVNKGWQ 783
            |:..:.|              ||  .||          ....|.|......|:.....:..||:|
Human  1223 LMGEDGP--------------PGPPGVT----------GVRGPEGKSGKQGEKGRTGAKGAKGYQ 1263

  Fly   784 YIALGTLVPIATPAPPTTVAPSMRFDLQSKNLLNSPPPLLNTPTWYPRMLRVAALNEPSTGDLQG 848
            . .||.:.....|.||.|..|.     .|:..|.        ||..|.  |:.|..||......|
Human  1264 G-QLGEMGVPGDPGPPGTPGPK-----GSRGSLG--------PTGAPG--RMGAQGEPGLAGYDG 1312

  Fly   849 IRG 851
            .:|
Human  1313 HKG 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mp	NP_001246651.1	LamG	58..222	CDD:473984	231/783 (30%)
		gly_rich_SclB	<292..>421	CDD:468478	50/191 (26%)
		gly_rich_SclB	<379..>616	CDD:468478	119/348 (34%)
		Collagen_trimer	744..792	CDD:466257	10/47 (21%)
		Endostatin-like	831..999	CDD:238151	6/21 (29%)
COL27A1	NP_116277.2	LamG	45..220	CDD:473984
		PHA03247	<274..605	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	278..608
		Triple-helical region	625..1618		231/783 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	625..772		42/172 (24%)
		gly_rich_SclB	<709..>989	CDD:468478	92/311 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	851..1625		169/525 (32%)
		gly_rich_SclB	<974..>1249	CDD:468478	103/315 (33%)
		gly_rich_SclB	<1183..>1449	CDD:468478	41/179 (23%)
		gly_rich_SclB	<1369..>1598	CDD:468478
		COLFI	1661..1859	CDD:470578