DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mp and COL18A1

DIOPT Version :10

Sequence 1:NP_001246651.1 Gene:Mp / 38769 FlyBaseID:FBgn0260660 Length:1039 Species:Drosophila melanogaster
Sequence 2:NP_569711.2 Gene:COL18A1 / 80781 HGNCID:2195 Length:1751 Species:Homo sapiens


Alignment Length:1399 Identity:383/1399 - (27%)
Similarity:515/1399 - (36%) Gaps:514/1399 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 CTLLVPV-------LGSFELVGQSIKDALAEYTLTDIMNNNQFAGIE--FG-EAEDG------FP 63
            |.|:.|.       :|..:|:|......:.:....|:       |:.  || :|..|      ||
Human   443 CVLIGPAAERISEEVGLLQLLGDPPPQQVTQTDDPDV-------GLAYVFGPDANSGQVARYHFP 500

  Fly    64 AFRFLQTADVKSPYRMLLPEKLYEFAILITFRQSSLKGGYLFSVVNPLDTVVQLGVHLSPVVKNS 128
            :..|                  .:|::|...|.::...|.||::.:....:|.|||.||.|....
Human   501 SLFF------------------RDFSLLFHIRPATEGPGVLFAITDSAQAMVLLGVKLSGVQDGH 547

  Fly   129 YNVSLVYTQADQNIGRKLASFGVAHVPDKWNSIALQVLSDKVSFYYDCELRNTTLVTREPIELVF 193
            .::||:||:.........|||.:.....:|..:||.|....|:.|.|||......:.|....|..
Human   548 QDISLLYTEPGAGQTHTAASFRLPAFVGQWTHLALSVAGGFVALYVDCEEFQRMPLARSSRGLEL 612

  Fly   194 DSASTLYIGQAGSIIGGKFEGYLEKINVYGNPDAINVTCM------------------------- 233
            :..:.|::.|||.....||:|.:.::.|..:|....:.|:                         
Human   613 EPGAGLFVAQAGGADPDKFQGVIAELKVRRDPQVSPMHCLDEEGDDSDGASGDSGSGLGDARELL 677

  Fly   234 --------------PPPKATIAPTTADDGSIFYEGSGENILFEDSTEANILSDDFWNTGDEATDI 284
                          |||..|  |..|...|.  |.|....:.|.:|.|::.:...  .|.::...
Human   678 REETGAALKPRLPAPPPVTT--PPLAGGSST--EDSRSEEVEEQTTVASLGAQTL--PGSDSVST 736

  Fly   285 FDASGMQPPGQTQYTHERPYRGIKGEKGER----------------------------------- 314
            :|.|...|.|:.:      ..|:||:|||.                                   
Human   737 WDGSVRTPGGRVK------EGGLKGQKGEPGVPGPPGRAGPPGSPCLPGPPGLPCPVSPLGPAGP 795

  Fly   315 ---------------------------------------------------GPKGD------SIR 322
                                                               |||||      ..|
Human   796 ALQTVPGPQGPPGPPGRDGTPGRDGEPGDPGEDGKPGDTGPQGFPGTPGDVGPKGDKGDPGVGER 860

  Fly   323 GPPGPPGPPGPKGETAPYPPFVETTSAGAKYTGECTC---------------------------- 359
            |||||.|||||.|.:..:.........|:.:.|:...                            
Human   861 GPPGPQGPPGPPGPSFRHDKLTFIDMEGSGFGGDLEALRGPRGFPGPPGPPGVPGLPGEPGRFGV 925

  Fly   360 NASDI-----LEAIKDNESLR--ESLRGAPGTPGKDGKPGTPGHTGA---TGVPGARGARGSEGA 414
            |:||:     |..:...|...  ..|.|.||.||::|.||..|..|:   .|.||.:|::|:.|.
Human   926 NSSDVPGPAGLPGVPGREGPPGFPGLPGPPGPPGREGPPGRTGQKGSLGEAGAPGHKGSKGAPGP 990

  Fly   415 QGLKGEPGVDGLPGVMGPPGPPGP-----PGLPENYDESLMVNSMGAFRGTTQ------------ 462
            .|.:||.|:.|.||..||||||||     ||||..:|:  |..|.|.|..|.:            
Human   991 AGARGESGLAGAPGPAGPPGPPGPPGPPGPGLPAGFDD--MEGSGGPFWSTARSADGPQGPPGLP 1053

  Fly   463 -----------PGAK------GVP---------------GEKGDAGQKGERGDP----------- 484
                       ||||      |||               |.|||.|.:||:|||           
Human  1054 GLKGDPGVPGLPGAKGEVGADGVPGFPGLPGREGIAGPQGPKGDRGSRGEKGDPGKDGVGQPGLP 1118

  Fly   485 -----------------------------------------------GHKGAHGPSGAKGEPGE- 501
                                                           |.:|:.||.|.|||||. 
Human  1119 GPPGPPGPVVYVSEQDGSVLSVPGPEGRPGFAGFPGPAGPKGNLGSKGERGSPGPKGEKGEPGSI 1183

  Fly   502 ---------------PGTPGLPGLPGQVGQPG--------GLDGLASANGTKGEKGEKGEK---- 539
                           .|.||..|.||..|:||        |..|....||.||||||.|:.    
Human  1184 FSPDGGALGPAQKGAKGEPGFRGPPGPYGRPGYKGEIGFPGRPGRPGMNGLKGEKGEPGDASLGF 1248

  Fly   540 GMRGRRGGTGATGPIGPPG-------------KPGPMGDIGHSGRPGMTGPKGEMGPKGPKGD-- 589
            ||||..|..|..||.||||             :|||.|..|:.|.||..|.|||:||.||.|.  
Human  1249 GMRGMPGPPGPPGPPGPPGTPVYDSNVFAESSRPGPPGLPGNQGPPGPKGAKGEVGPPGPPGQFP 1313

  Fly   590 ------SGGREGLKGDKGDRGQDGRDGLPGPPGLPSTGGGDGDSGGVQYIPMPGPPGPPGPPGLP 648
                  ....:|.|||:||.||.|..|.||       |||...|.      :|||||||||.|.|
Human  1314 FDFLQLEAEMKGEKGDRGDAGQKGERGEPG-------GGGFFGSS------LPGPPGPPGPRGYP 1365

  Fly   649 GLSISGPKGE--------------PGVDSRSSFFGDASYYGRPGARSSLDELKALRELQDLRDRP 699
            |  |.|||||              ||:          .|.||.|                    |
Human  1366 G--IPGPKGESIRGQPGPPGPQGPPGI----------GYEGRQG--------------------P 1398

  Fly   700 DGTAEPPRQPGHSHKHEETLGLVDGE--------EPYFSASSSNMNMKIVPGAVTFQNIDEMTKK 756
            .|...||..|.....|.:|:. |.|.        .|....:||.:.:.....|:..| :.|:   
Human  1399 PGPPGPPGPPSFPGPHRQTIS-VPGPPGPPGPPGPPGTMGASSGVRLWATRQAMLGQ-VHEV--- 1458

  Fly   757 SALNPPGTLAYITEEEALLVRVNKGWQYIALGTLVPI--------------------ATPAP--- 798
                |.|.|.::.|:|.|.|||..|::.:.|....|:                    :.|.|   
Human  1459 ----PEGWLIFVAEQEELYVRVQNGFRKVQLEARTPLPRGTDNEVAALQPPVVQLHDSNPYPRRE 1519

  Fly   799 -PTTVAPSMRFDLQSKNLLNSPPPLLNTPTWYP----------------------------RMLR 834
             |...|...|.|    ::|.| ||.|..|..||                            .:|.
Human  1520 HPHPTARPWRAD----DILAS-PPRLPEPQPYPGAPHHSSYVHLRPARPTSPPAHSHRDFQPVLH 1579

  Fly   835 VAALNEPSTGDLQGIRGADFACYRQGRRAGLLGTFKAFLSSRVQNLDTIVRPADR-DLPVVNTRG 898
            :.|||.|.:|.::|||||||.|::|.|..||.|||:||||||:|:|.:|||.||| .:|:||.:.
Human  1580 LVALNSPLSGGMRGIRGADFQCFQQARAVGLAGTFRAFLSSRLQDLYSIVRRADRAAVPIVNLKD 1644

  Fly   899 DVLFNSWKGIFNGQGGFFSQAPRIYSFSGKNVMTDSTWPMKMVWHGSLPNGERSMDTYCDAWHSG 963
            ::||.||:.:|:|..|......||:||.||:|:...|||.|.|||||.|||.|..::||:.|.:.
Human  1645 ELLFPSWEALFSGSEGPLKPGARIFSFDGKDVLRHPTWPQKSVWHGSDPNGRRLTESYCETWRTE 1709

  Fly   964 DHLKGSFASNLDGHKLLEQKRQSCDSKLIILCVE 997
            .......||:|.|.:||.|...||....|:||:|
Human  1710 APSATGQASSLLGGRLLGQSAASCHHAYIVLCIE 1743

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MpNP_001246651.1 LamG 58..222 CDD:473984 43/169 (25%)
gly_rich_SclB <292..>421 CDD:468478 51/258 (20%)
gly_rich_SclB <379..>616 CDD:468478 129/395 (33%)
Collagen_trimer 744..792 CDD:466257 14/47 (30%)
Endostatin-like 831..999 CDD:238151 81/168 (48%)
COL18A1NP_569711.2 DUF959 23..194 CDD:399255
PHA03247 <156..345 CDD:223021
CRD_Collagen_XVIII 330..452 CDD:143564 3/8 (38%)
TSPN 456..644 CDD:214560 51/212 (24%)
gly_rich_SclB <713..>856 CDD:468478 19/150 (13%)
gly_rich_SclB <789..>995 CDD:468478 42/205 (20%)
gly_rich_SclB <1056..>1246 CDD:468478 47/189 (25%)
Collagen_trimer 1442..1490 CDD:466257 14/55 (25%)
Endostatin-like 1575..1745 CDD:238151 81/169 (48%)
Blue background indicates that the domain is not in the aligned region.

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