DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mp and col15a1a

DIOPT Version :9

Sequence 1:	NP_001246651.1	Gene:	Mp / 38769	FlyBaseID:	FBgn0260660	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_021326097.1	Gene:	col15a1a / 792366	ZFINID:	ZDB-GENE-080918-1	Length:	1168	Species:	Danio rerio

Alignment Length:	1215	Identity:	362/1215 - (29%)
Similarity:	490/1215 - (40%)	Gaps:	337/1215 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MFALAMICTLLVPVLGSFELVGQSIKD--ALAEYTLTDIMNNNQFAGIEFGEAEDGFPAFRFLQT 70
            :|..|.||:          ..|.|:.|  ::.:..||:::.......:.|....:||||:.|...
Zfish    58 IFIAASICS----------AAGASLSDDVSVDQLDLTELIGVPLPPSVSFVTGLEGFPAYSFGAD 112

  Fly    71 ADVKSPYRMLLPEKLY-EFAILITFRQSSLKGGYLFSVVNPLDTVVQLGVHLSPVVKNSYNVSLV 134
            |:|....|..||:..: :|:|.:|.:.:|.:||.||:|.:....||||||.|:|....|..|.|.
Zfish   113 ANVGRLARSFLPDPFFRDFSITVTAKATSRRGGVLFAVTDAQQRVVQLGVSLAPAEDGSQRVILY 177

  Fly   135 YTQADQNIGRKLASFGVAHVPDKWNSIALQVLSDKVSFYYDCELRNTTLVTREPIELVFDSASTL 199
            ||:|.....::.|:|.:|.:..:|.|.:|.|...:|..:.|||...:...:|....|.|.|.:.:
Zfish   178 YTEAGAERTQEAAAFKMAELTGRWASFSLSVQRGEVQLWADCERVQSATFSRSLEPLTFHSRAGI 242

  Fly   200 YIGQAGSIIGGKFEGYLEKINVYGNPDAINVTCMP----PPKATIAPTTA----------DDGSI 250
            :||.||:.....|:|.::::.:..:|.|....|..    |....::|..|          ||..:
Zfish   243 FIGNAGATRMQSFQGLIQQLLLTSDPSAPERQCEEDDPYPVDVELSPVRAPPTEDPELYTDDEDL 307

  Fly   251 FYE--GSGENILFEDSTEANILSDDFWNTGDEATDIFDASGMQPPGQTQYTHERPYRGIKGEKGE 313
            ..|  .||::.|...||| .|.|:.       |:...:...||                ||:|||
Zfish   308 TEEEDASGDSTLMHSSTE-RIRSEG-------ASQDRNVITMQ----------------KGQKGE 348

  Fly   314 RGPKGDSIRGPPGPPGPPGP---KGETAPYPPFVETTSAGAK-YTGE------------------ 356
            ||..     |||||||||.|   .||..|..|...|.:.||: .||:
Zfish   349 RGSP-----GPPGPPGPPAPHHTDGEPGPRGPQGPTGAPGARGETGDAGRDGAPGEVGPPGFPGL 408

  Fly   357 ---------------CTCN-----------ASDILEAIKDNESLRES------------------ 377
                           |..|           .|..::|..|.|.:|.|
Zfish   409 AGDPGPKGEKVRQVFCCWNIRVDHDGHDGSGSRYVDADSDTELMRVSCSPLGAAGVIRHTHCSHC 473

  Fly   378 ---LRGAPGTPGKDGKPGTPGHTGATGVPGARGARGSEGAQGLKGEPGVDGLP------------ 427
               .:|..|..|:.||.|.||..|..||||..||:|..|..|..|.||..|.|
Zfish   474 CCVFQGDSGADGQPGKDGAPGQKGEAGVPGVSGAQGEPGRPGPPGPPGPSGAPGRPFSFDMMDLE 538

  Fly   428 --GVMG--------PPGPPGPPGLPENYDESLMVNSMGAF----------RGTT----QPGAKGV 468
              ||.|        |.||||.||||....:.......|..          .|.|    .|||:|.
Zfish   539 GSGVDGGSVFRPVLPRGPPGLPGLPGPQGKEGAAGPPGVSVKGEPGAKGDHGETGAPGMPGAQGE 603

  Fly   469 PGEKGDAGQKGER--------------GDPGH------------------------KGAHGPSGA 495
            .|:|||.||||||              |.||.                        :||.||.|.
Zfish   604 TGQKGDTGQKGERGLDGVCLPGPPGPPGPPGPFISLQELMLNDTEGVFNISSISELQGAAGPRGP 668

  Fly   496 KGEPGEPGTPGLPGLPGQVGQPGGLDGLASANGTKGEKGEKGEKGMRGRRGGTGATGPIGPPGKP 560
            ||:.|.||..|.|||.||.|:|      |..:|..|.:|..|.||.||..|..|..||.||.|:.
Zfish   669 KGDAGAPGLHGAPGLKGQKGEP------ALVSGALGPQGPSGLKGDRGAPGPAGEQGPAGPAGEK 727

  Fly   561 GPMGDIGHSGRPGMTGPKGEM-------GPKGPKGDSG--------------------------- 591
            |..|..|.:||||:.|.|||.       ||.||.|..|
Zfish   728 GEFGFPGRAGRPGLNGRKGEKGDSAGAPGPPGPPGPPGRPAIFNCPKGMVFPVPPRPHCKQPVNG 792

  Fly   592 -------------GREGLKGDKGDRGQDGRDGLPGPPGLPSTGGGDGDSGGVQYIPMPGPPGPPG 643
                         ..:|.:|.:|::|:.|..||||..||  ..|..|:|    .|..||.|||.|
Zfish   793 GFTQGDSLDNRVTAGDGEQGTRGEKGEAGMPGLPGKSGL--LQGPKGES----VIGPPGHPGPRG 851

  Fly   644 PPGLPGL---SISGPKGEPGVDSRSSFFGDASYYGRPGA-RSSLDELKALRELQDLRDRPDGTAE 704
            |||.|||   .::||.|.||..            |.||. ||.|           :...|.|
Zfish   852 PPGAPGLGRTGVAGPPGPPGPP------------GPPGQHRSGL-----------MIPGPPG--- 890

  Fly   705 PPRQPGHSHKHEETLGLVDGEEPYFSASSSNMNMKIVPGAVTFQNIDEMTKKSALNPPGTLAYIT 769
            ||..||.:                 .|||:.:....|          ::.::..|...|:||:||
Zfish   891 PPGPPGRA-----------------EASSTLLRFVSV----------QLMQQQVLVQDGSLAFIT 928

  Fly   770 EEEALLVRVNKGWQYIALGTLVPIATPAPPTTVAPS----MRFDLQSKNLLNSPPPLLNTPTWYP 830
            :...|.::|.:||:.:.||.|:. :.|:...|:..:    :|..:..|:...:..||:..|....
Zfish   929 DSSKLYLKVPRGWREVQLGVLLE-SYPSAGHTLNDAQLLFLRPQMNHKHTGQTAQPLILKPQMTS 992

  Fly   831 -------RMLRVAALNEPSTGDLQGIRGADFACYRQGRRAGLLGTFKAFLSSRVQNLDTIVRPAD 888
                   :.|||||||.|..|||   |.|...|..|.:..|:...|:.||:.|...|..:|....
Zfish   993 AHTIHTGQALRVAALNAPLAGDL---RSASQLCRTQAQALGISNGFQPFLTHRTLELRDLVPAEY 1054

  Fly   889 RDLPVVNTRGDVLFNSWKGIFNGQGGFFSQAPRIYSFSGKNVMTDSTWPMKMVWHGSLPNGERSM 953
            ..||:.|.||||||.|||.||:..  .......:|||.|::||:|..||.|.|||||...|....
Zfish  1055 SSLPITNLRGDVLFKSWKSIFSNH--LLPPGVPLYSFDGRDVMSDPFWPQKAVWHGSSVGGAGLS 1117

  Fly   954 DTYCDAWHSGD-HLKGSFASNLDGHKLLEQKRQSCDSKLIILCVE 997
            ...||.|.|.| .|.|..:....|  ||.|..:||.::.|:||||
Zfish  1118 AVSCDWWRSADLALSGQASFLYSG--LLSQHTRSCSNRFIVLCVE 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mp	NP_001246651.1	LamG	58..222	CDD:304605	54/164 (33%)
		Collagen	378..432	CDD:189968	26/75 (35%)
		Collagen	464..518	CDD:189968	33/91 (36%)
		Collagen	494..615	CDD:189968	56/167 (34%)
		Endostatin-like	831..999	CDD:238151	70/168 (42%)
col15a1a	XP_021326097.1	LamG	80..268	CDD:328935	57/187 (30%)
		Collagen	368..417	CDD:189968	9/48 (19%)
		Collagen	581..676	CDD:189968	27/94 (29%)
		Collagen	673..734	CDD:189968	29/66 (44%)
		Endostatin-like	1001..1160	CDD:329216	68/165 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1362001at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010