DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mp and col18a1a

DIOPT Version :9

Sequence 1:	NP_001246651.1	Gene:	Mp / 38769	FlyBaseID:	FBgn0260660	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_021334395.1	Gene:	col18a1a / 564123	ZFINID:	ZDB-GENE-030516-3	Length:	1645	Species:	Danio rerio

Alignment Length:	1461	Identity:	386/1461 - (26%)
Similarity:	529/1461 - (36%)	Gaps:	549/1461 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CTLLVPVLG----------SFELVGQSIKDALAE-----------------YTLTDIMNNNQFAG 52
            |.||.|..|          |.|::..|....|.|                 |....:.|..:.:|
Zfish   263 CLLLTPRCGHSGSLLPCRSSCEVLQDSCWTLLDEGRLPVECKSLPEEKHDGYRCLSVSNLKEESG 327

  Fly    53 IE----------------FGEAEDGFPAFRFLQTADVKSPYRMLLPEKLY-EFAILITFRQSSLK 100
            :.                |.:|..  |.:.|..:::|.......||...| :|:::...:.:|.|
Zfish   328 VSLLQLIGDPPPNGVSKVFDQANS--PGYVFGPSSNVGQSAAAHLPNPFYRDFSLIFNIKPTSSK 390

  Fly   101 GGYLFSVVNPLDTVVQLGVHLSPVVKNSYNVSLVYTQADQNIGRKLASFGVAHVPDKWNSIALQV 165
            .|.:||:.:|...::.:||.||.|.:...::...||:.|.....:.|.|.|:.:.:.|...::.|
Zfish   391 PGVIFSITDPTQNIMYVGVKLSAVERGKQSIIFYYTEPDSQSSYEAARFSVSSMLNIWTRFSISV 455

  Fly   166 LSDKVSFYYDCELRNTTLVT--REPIELVFDSASTLYIGQAGSIIGGKFEGYLEKINVYGNPDAI 228
            |:::||.|::|: .:..:|.  |.|.::..|:.:.:::|.|......||.|.:..:.|..:|.|.
Zfish   456 LNEQVSLYFNCD-SDPQVVNFERSPDDMDMDAGAGVFVGHASGADPDKFLGVIGDLRVSRDPGAA 519

  Fly   229 NVTCMPPPKATIAPTTADDGSIFYEGSGEN------------------ILFEDSTE-ANILSDDF 274
            ...|...........:.|.|:   .|.||.                  ::..|..: ..::|
Zfish   520 ERHCEEEEDDYATEASGDYGA---SGDGEQPSPVQPTPPSSRPIQRPPVISRDPIQRPPVIS--- 578

  Fly   275 WNTGDEATDIFDASGMQPPGQTQYTHERPYRGIKGEKGER---GPKGD----SI----------- 321
                           .:|..||....|:..||.||.||:|   |||||    |:
Zfish   579 ---------------REPIQQTVARGEKGDRGEKGAKGDRGLAGPKGDVGSGSVSGGGSKGDKGV 628

  Fly   322 --------------------RGPPGPPGPPGPKGETAPYPPFVETTSAGA---KYTGECTCNASD 363
                                ||||||||||||:|.:|.    ||....|:   |.||.
Zfish   629 PGEKGMKGTSGFGYPGSKGDRGPPGPPGPPGPQGPSAE----VEVRGDGSVVQKVTGP------- 682

  Fly   364 ILEAIKDNESLR--ESLRGAPGTPGKDGKPGTPGHTGATGVPGARGARGSEGAQGLKGEPGVDG- 425
                       |  ...:|.||.||.:|:||.||..|..|..|..|..|:.|..|.||:.|..|
Zfish   683 -----------RGPPGPQGPPGPPGPEGEPGDPGEDGKAGQVGPSGFPGNPGNPGPKGDKGDRGE 736

  Fly   426 -LPGVMGPPGPPGPPGLPENYDESLMVNSMG-----------------------------AFRGT 460
             .||..||||||||||....:|....|:..|                             |..|:
Zfish   737 SQPGPRGPPGPPGPPGPSSGFDRPTFVDMEGSGFDMDSVRAVPGLPGPPGPPGPPGPPGSASSGS 801

  Fly   461 ---------------TQPGAKGVP------------GEKGDAGQKGERGDPGHKGAH-------- 490
                           .|||..|||            |||||||:.|..|..|.|||.
Zfish   802 GGFGPPGPPGQNGAPGQPGLSGVPGADGKPGLPGPKGEKGDAGELGLPGPVGEKGAKGSSGPPGT 866

  Fly   491 -------------GPSGAKGEPGEP----------------------------GTPGLPGLPGQV 514
                         ||.|..|.||.|                            |.||.||:||..
Zfish   867 TGIGGPAGLPGPIGPIGLPGPPGPPGPSFNVGFDDMEGSGVHFSSVPGVRGPVGIPGPPGVPGPQ 931

  Fly   515 GQPG--------------GLDGLASANGTKGEKGEKGEKGMRGRRGGTGATG---PIGPPGKPGP 562
            ||||              |.|||..|:|..|.:|.||:||.||.||..|..|   | |.||.|||
Zfish   932 GQPGFPGLPGEKGSLGAQGNDGLPGADGFPGPQGPKGDKGERGDRGEPGRDGHGHP-GQPGPPGP 995

  Fly   563 MGDI-----------------GHSGRPGMTGPKGEMGPKGPKGDSG-------GRE--------- 594
            .|.|                 |.||.||..|..|.|||||.:|:.|       |.:
Zfish   996 PGQIIYRYSEHYDEVGGTGAQGGSGVPGQAGFPGPMGPKGDRGEPGLPGYDIKGEKGEPGLILGP 1060

  Fly   595 --------GLKGDKGDRGQDGRDGLPGP---------------PGLPSTGGGDGDSG------GV 630
                    ||.|.||:||..|..|.|||               ||.|...|..|:.|      |.
Zfish  1061 DGNPLYLGGLTGQKGERGISGPVGPPGPAGPPGAKGEFGMPGRPGRPGVNGYKGEKGEPSSGSGY 1125

  Fly   631 QYIPMPGPPGPPGPPGLPGLSI---------------------SGPKGEPGVDSRSSFFGDASYY 674
            .|   |||||||||||.||.::                     .|.:|.||:.
Zfish  1126 GY---PGPPGPPGPPGPPGPAVPLDRFGRYEDYARLYPATKGEKGDQGAPGIP------------ 1175

  Fly   675 GRPGARSSLD------ELKALRELQDLRDR----------------------------------- 698
            |.||..::.|      |:|..|....|:..
Zfish  1176 GSPGFSTNFDIYSLKNEMKGERGESGLKGEKGEPGGGFYDPRFGAVQGPPGNPGPAGPKGDSIRG 1240

  Fly   699 PDGTAEPPRQPGHSHKHEETLGLVDGEE-------------------PYFSASSSNMNMKIVP-- 742
            |.|...||..||..:         ||..                   ||....|       :|
Zfish  1241 PPGPQGPPGTPGVGY---------DGRPGNPGPPGPPGPPGSPSLPGPYRPPLS-------IPGP 1289

  Fly   743 --------------GAVTFQNIDEMTKKSALNPPGTLAYITEEEALLVRVNKGWQYIALGTLVPI 793
                          |....::.|.|...:.....|||.||.:...|.:||..|.:.:.||...|:
Zfish  1290 PGPPGPPGIPGTGSGVTVLRSHDIMIATARRQTEGTLIYILDRNDLYLRVRDGVRQVMLGDYKPL 1354

  Fly   794 ---------ATPAPPTT------------------------------------------------ 801
                     |...||..
Zfish  1355 YGELDNEVAAVQPPPVVHYSQDHTANNGAEQISPPHQPIDFPTREQENRNPNPQPDPRYPDPRYP 1419

  Fly   802 ----------VAPSMRFDLQ-SKNLL---NSPPPLLNTPTWYPRM------LRVAALNEPSTGDL 846
                      |.|::|:.:| .:|.:   ..|.|.:|.|..:...      |.:.|||.|..|::
Zfish  1420 PYTDNRYTDPVEPNIRYPVQPERNPITPARRPIPPVNQPGGHAHTHTSGPGLHLIALNSPQVGNM 1484

  Fly   847 QGIRGADFACYRQGRRAGLLGTFKAFLSSRVQNLDTIVRPADRD-LPVVNTRGDVLFNSWKGIFN 910
            :|||||||.|::|.|..|:.|||:|||||::|:|.:|||.:||: ||:||.:..|||:||:.:|:
Zfish  1485 RGIRGADFMCFQQARAVGMKGTFRAFLSSKLQDLYSIVRRSDRETLPIVNLKDQVLFSSWESLFS 1549

  Fly   911 GQGGFFSQAPRIYSFSGKNVMTDSTWPMKMVWHGSLPNGERSMDTYCDAWHSGDHLKGSFASNLD 975
            ...........||||.|::|:.||.||.||:||||...|.|..|.||:.|.:||......||:|.
Zfish  1550 DSESRMKDNAPIYSFDGRDVLRDSAWPEKMIWHGSDGRGHRQTDNYCETWRAGDRAVTGLASSLQ 1614

  Fly   976 GHKLLEQKRQSCDSKLIILCVE--ALSQDRK 1004
            ..:||:|...||.|..|:||:|  .::|.:|
Zfish  1615 AGQLLQQTSSSCSSSYIVLCIENSYMTQSKK 1645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mp	NP_001246651.1	LamG	58..222	CDD:304605	41/166 (25%)
		Collagen	378..432	CDD:189968	23/55 (42%)
		Collagen	464..518	CDD:189968	33/114 (29%)
		Collagen	494..615	CDD:189968	70/221 (32%)
		Endostatin-like	831..999	CDD:238151	79/176 (45%)
col18a1a	XP_021334395.1	CRD_Collagen_XVIII	203..340	CDD:143564	13/76 (17%)
		LamG	327..516	CDD:328935	44/191 (23%)
		Collagen	816..860	CDD:189968	19/43 (44%)
		Collagen	<937..980	CDD:189968	16/42 (38%)
		Collagen	959..1055	CDD:189968	37/96 (39%)
		Endostatin	1471..1639	CDD:310825	79/167 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3518
eggNOG	1	0.900	-	-		E1_KOG3546
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	422	1.000	Inparanoid score	I1759
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1362001at2759
OrthoFinder	1	1.000	-	-		FOG0002295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106129
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1979
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.730