DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mp and col14a1a

DIOPT Version :9

Sequence 1:	NP_001246651.1	Gene:	Mp / 38769	FlyBaseID:	FBgn0260660	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_009290436.1	Gene:	col14a1a / 321298	ZFINID:	ZDB-GENE-030131-9889	Length:	1879	Species:	Danio rerio

Alignment Length:	824	Identity:	214/824 - (25%)
Similarity:	285/824 - (34%)	Gaps:	314/824 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 IMNNNQFAGIE----FGEAE----------------DGFPAFRFLQTADVKSPYRMLLPEKLYEF 88
            :|:.|..||..    ||.||                :.||.:|..:.|.|..|.|.|.||.|
Zfish  1221 LMSGNTLAGFRMMEMFGLAEKHYSSVQGVSMEPGTFNSFPCYRLHKDALVSQPTRYLHPEGL--- 1282

  Fly    89 AILITFRQSSLKGGYLFSVVNPLDTVVQLGVHLSPVVKNSYNVSLVY---TQADQNIGRKLASFG 150
                                 |.|                |.:|:::   .:..|.      .|.
Zfish  1283 ---------------------PSD----------------YTISMLFRILPETPQE------PFA 1304

  Fly   151 VAHVPDKWNSIALQVLSDK----VSFY---YDCELRNTTLVTREPIELVFDSASTLYIG----QA 204
            :..:.||.|...:.::.|.    ::|:   |..|.:..|....|..::.:.|...|::.    .|
Zfish  1305 LWEILDKNNEPLVGIILDNGGKTLTFFNSDYKGEFQTVTFEGPEIKKIFYGSFHKLHVAISKTAA 1369

  Fly   205 GSIIGGKFEGYLEK-INVYGNPDAINVTCMPPPKATIAPTTADDGSIFYEGSGENILFEDSTEAN 268
            ..:|..|..|  || ||..||   |::..:......:......|.|..::..    :|:
Zfish  1370 KVVIDCKTVG--EKSINAAGN---ISIDGVEVLGRMVRSRGRKDNSAPFQLQ----MFD------ 1419

  Fly   269 ILSDDFWNTGDEATDI-------------------FDASG----MQPPGQTQYTHERPYRGIKGE 310
            |:....|.:.|:..::                   .|:.|    ..|||..         ||:|.
Zfish  1420 IVCSTSWASRDKCCELPGLRVEEDCPAMPHACTCAQDSKGPPGPSGPPGGP---------GIRGS 1475

  Fly   311 KGERGPKG-----------DSIR-----------GPPGPPGPPGPKGETAPYPPFVETTSAGAKY 353
            :|:||..|           .:.|           |||||.|||||:|...
Zfish  1476 RGDRGEPGLTETAGHSHFVSAARLVGSQGLPGEIGPPGPQGPPGPQGPNG--------------- 1525

  Fly   354 TGECTCNASDILEAIKDNESLRESLRGAPGTPGKDGKPGTPGHTGATGVPGARGARGSEGAQGLK 418
                                  .|::|.||.||:.|..|..|..|..|||||.|..|.:|..|.:
Zfish  1526 ----------------------LSIQGPPGAPGEKGDKGEIGLPGPQGVPGANGGPGRDGPPGQR 1568

  Fly   419 GEPGVDGLPGVMGPPGPPGPPGLPENYDESLMVNSMGAFRGTTQPGAKGVPGEKGD------AGQ 477
            |.||.||..|..|||||.|.||.|            ||      ||:.|.||:.||      ||.
Zfish  1569 GLPGKDGPQGRQGPPGPMGSPGAP------------GA------PGSNGPPGQLGDQGPPGPAGT 1615

  Fly   478 KGERGDPGHKGAHG----------------------------PSGA------KGEPGEPGTPGLP 508
            |||||:.|...:|.                            ||.:      .|.|||||.|||.
Zfish  1616 KGERGERGDMQSHAAVRAIARQVCEQLIQSHLSRYNSILNQIPSQSVSVRTVPGPPGEPGRPGLQ 1680

  Fly   509 GLPGQVGQPG--GLDGLASANGTKGEKGEKGEKGMRGRRGGTGATGPIGPPGKPGPMGDIGHSGR 571
            |..|:.|.||  |..|.:..||..||:|..||:|.:| ..|.|..||.||||.|||.|:    ||
Zfish  1681 GPQGEQGPPGRPGFPGASGQNGRPGERGLPGERGEKG-SPGVGTQGPRGPPGSPGPAGE----GR 1740

  Fly   572 PGMTGPKGEMGPKGPKGDSGGREGLKGDKGDRGQDGRDGLPGPPGLPSTGGGDGDSGGVQYIPMP 636
            .|..||.             ||.|::|.:|..|..|..|..||||........|.:.|||.:...
Zfish  1741 TGSQGPP-------------GRPGIQGTQGRPGTPGSPGPAGPPGYCDQNSCLGYNVGVQQLSSN 1792

  Fly   637 -----GP-----------PGPPG-----PPGLPGLSISGPKG-EPGVDSRSSFFGDASYYGRPGA 679
                 ||           ..|.|     ||.....|...|:| .||    ....||.:....|||
Zfish  1793 PYQNYGPATNYNPEDEEEDDPYGGYRAYPPQYYQPSYPDPRGARPG----PVHPGDTAGMRAPGA 1853

  Fly   680 ----RSSLDELKALRELQDLRDRPDGTAEPPRQPGHSHKHEETL 719
                ||:.:|               |....|::    |..||.|
Zfish  1854 RRFTRSTAEE---------------GIVHQPQE----HVKEEEL 1878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mp	NP_001246651.1	LamG	58..222	CDD:304605	38/194 (20%)
		Collagen	378..432	CDD:189968	24/53 (45%)
		Collagen	464..518	CDD:189968	29/93 (31%)
		Collagen	494..615	CDD:189968	51/128 (40%)
		Endostatin-like	831..999	CDD:238151
col14a1a	XP_009290436.1	fn3	31..109	CDD:278470
		vWA_collagen_alphaI-XII-like	157..320	CDD:238759
		FN3	356..442	CDD:238020
		FN3	448..533	CDD:238020
		FN3	538..617	CDD:238020
		fn3	626..700	CDD:278470
		fn3	735..809	CDD:278470
		fn3	824..904	CDD:278470
		fn3	916..991	CDD:278470
		vWA_collagen_alphaI-XII-like	1031..1195	CDD:238759
		TSPN	1229..1424	CDD:214560	48/255 (19%)
		Collagen	1530..1619	CDD:189968	46/106 (43%)
		Collagen	1680..1754	CDD:189968	36/91 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910