Protein Alignment Mp and COL15A1

DIOPT Version :10

• Sequence 1: NP_001246651.1
• Gene: Mp / 38769
• FlyBaseID: FBgn0260660
• Length: 1039
• Species: Drosophila melanogaster
• Sequence 2: NP_001846.3
• Gene: COL15A1 / 1306
• HGNCID: 2192
• Length: 1388
• Species: Homo sapiens
• Alignment Length: 1450
• Identity: 394/1450 - (27%)
• Similarity: 536/1450 - (36%)
• Gaps: 536/1450 - (36%)

  Fly     6 GVMFALAMICTLLVPVLGSFELVGQSIKDALAEYTLTDIMNNNQFAGIEFGEAEDGFPAFRFLQT 70
            |..:.|.|:.::..|:....:..|.:...:.....||.::.....:.:.|.....||||:.|...
Human     8 GQCWCLLMLLSVSTPLPAVTQTRGATETASQGHLDLTQLIGVPLPSSVSFVTGYGGFPAYSFGPG 72

  Fly    71 ADVKSPYRMLLPEKLY-EFAILITFRQSSLKGGYLFSVVNPLDTVVQLGVHLSPVVKNSYNVSLV 134
            |:|..|.|.|:|...: :|||.:..:.||.:||.||::.:....|:.||:.||.|......:.|.
Human    73 ANVGRPARTLIPSTFFRDFAISVVVKPSSTRGGVLFAITDAFQKVIYLGLRLSGVEDGHQRIILY 137

  Fly   135 YTQADQNIGRKLASFGVAHVPDKWNSIALQVLSDKVSFYYDCELRNTTLVTREPIELVFDSASTL 199
            ||:...::.::.|:|.|..:..:||..|:.|..::|:...:||..:.....|....|.|:|::.:
Human   138 YTEPGSHVSQEAAAFSVPVMTHRWNRFAMIVQGEEVTLLVNCEEHSRIPFQRSSQALAFESSAGI 202

  Fly   200 YIGQAGSIIGGKFEGYLEKINVYGNP-------------------------------DAINVTCM 233
            ::|.||:....:|.|.|:::.|:.:|                               :|:..|..
Human   203 FMGNAGATGLERFTGSLQQLTVHPDPRTPEELCDPEESSASGETSGLQEADGVAEILEAVTYTQA 267

  Fly   234 PPPKATIAP---------------------------TT--------------------------- 244
            .|.:|.:.|                           ||
Human   268 SPKEAKVEPINTPPTPSSPFEDMELSGEPVPEGTLETTNMSIIQHSSPKQGSGEILNDTLEGVHS 332

  Fly   245 ADDGSIFYEGSGENILFEDSTEANIL--------------------------------------- 270
            .|...|...|||.....:.:.|.|:.
Human   333 VDGDPITDSGSGAGAFLDIAEEKNLAATAAGLAEVPISTAGEAEASSVPTGGPTLSMSTENPEEG 397

  Fly   271 ---------------------------------------------------------SDDFWNTG 278
                                                                     |:|...|.
Human   398 VTPGPDNEERLAATAAGEAEALASMPGEVEASGVAPGELDLSMSAQSLGEEATVGPSSEDSLTTA 462

  Fly   279 DEATDIF-------DASG------------MQP-------PGQTQ----YTHERP---------- 303
            ..||::.       :|||            |.|       ||..:    .|.|.|
Human   463 AAATEVSLSTFEDEEASGVPTDGLAPLTATMAPERAVTSGPGDEEDLAAATTEEPLITAGGEESG 527

  Fly   304 --------------------------YRGIKGEKGERGPKGDSIRGPPGPPGPPGPKGETAPYPP 342
                                      :.|:||:.|.:|.|||:....||||.|.||.|.|
Human   528 SPPPDGPPLPLPTVAPERWITPAQREHVGMKGQAGPKGEKGDAGEELPGPPEPSGPVGPT----- 587

  Fly   343 FVETTSAGAKYTGECTCNASDILEAIKDNESLRESLRGAPGTPGK------DGKPGT-------- 393
                  |||:..|......||:.....|.....:.|||.||.||.      .|||||
Human   588 ------AGAEAEGSGLGWGSDVGSGSGDLVGSEQLLRGPPGPPGPPGLPGIPGKPGTDVFMGPPG 646

  Fly   394 -------------------PGHTGATGVP---GARGARGSEGAQGLKGEPGVDGL---------- 426
                               ||..||||:|   |.:||||..|:.|.||:||..||
Human   647 SPGEDGPAGEPGPPGPEGQPGVDGATGLPGMKGEKGARGPNGSVGEKGDPGNRGLPGPPGKKGQA 711

  Fly   427 --PGVMGPPGPPGPPGLP-------------ENYDESLMVNSMGAFRGTTQPGAKGVPGEKGDAG 476
              ||||||||||||||.|             |....:.::|.....|.|   .|.|:.|||||.|
Human   712 GPPGVMGPPGPPGPPGPPGPGCTMGLGFEDTEGSGSTQLLNEPKLSRPT---AAIGLKGEKGDRG 773

  Fly   477 QKGERGDPGHK-----GAHGPSG------------------------AKGEPGEPGTPGLPGLPG 512
            .|||||..|..     |..||.|                        ..|.||..|.|||||.||
Human   774 PKGERGMDGASIVGPPGPRGPPGHIKVLSNSLINITHGFMNFSDIPELVGPPGPDGLPGLPGFPG 838

  Fly   513 QVGQPGGLDGLASANGTKGEKGEKGE--------------KGMRGRRGGTGATGPIGPPGKPGPM 563
            ..| |.|..||....|.|||:|||||              .|.:|..|..||.||:||.|.||..
Human   839 PRG-PKGDTGLPGFPGLKGEQGEKGEPGAILTEDIPLERLMGKKGEPGMHGAPGPMGPKGPPGHK 902

  Fly   564 GDIGHSGRPG-----------------MTGPKGEMGPKGP------------------------- 586
            |:.|..||||                 |.||.|..||.||
Human   903 GEFGLPGRPGRPGLNGLKGTKGDPGVIMQGPPGLPGPPGPPGPPGAVINIKGAIFPIPVRPHCKM 967

  Fly   587 ------------------KGDSG--GREGLKGDKGDRGQDGRDGLP------------------- 612
                              ||:.|  |..|.||:|||:|..|..|.|
Human   968 PVDTAHPGSPELITFHGVKGEKGSWGLPGSKGEKGDQGAQGPPGPPLDLAYLRHFLNNLKGENGD 1032

  Fly   613 --------------------GPPGLPSTGGGDGDSGGVQYIPMPGPPGPPGPPGLPGLSISGPKG 657
                                ||||||...|..|..|..    :.||.||||.|||||....|..|
Human  1033 KGFKGEKGEKGDINGSFLMSGPPGLPGNPGPAGQKGET----VVGPQGPPGAPGLPGPPGFGRPG 1093

  Fly   658 EPGVDSRSSFFGDASYYGRPGARSSLDELKALRELQDLRDRPDGTAEPPRQPGHSHKHEETLGLV 722
            :||.....         |.||..:.|....||          .|...||.|||
Human  1094 DPGPPGPP---------GPPGPPAILGAAVAL----------PGPPGPPGQPG------------ 1127

  Fly   723 DGEEPYFSASSSNMNMKIVPGA----VTFQNIDEMTKKSALNPPGTLAYITEEEALLVRVNKGWQ 783
                              :||:    ..|.|:|:|.:|:.|...||..|:.:.....:||..||:
Human  1128 ------------------LPGSRNLVTAFSNMDDMLQKAHLVIEGTFIYLRDSTEFFIRVRDGWK 1174

  Fly   784 YIALGTLVPIATPAPPTTVAPSMRFDLQSKNLLNSPPPLLNTPTWYPRMLRVAALNEPSTGDLQG 848
            .:.||.|:||...:||.....|      :.:.|..||..:::..:....|.:||||.|.:||::
Human  1175 KLQLGELIPIPADSPPPPALSS------NPHQLLPPPNPISSANYEKPALHLAALNMPFSGDIR- 1232

  Fly   849 IRGADFACYRQGRRAGLLGTFKAFLSSRVQNLDTIVRPADR-DLPVVNTRGDVLFNSWKGIFNGQ 912
               |||.|::|.|.||||.|::|||||.:|:|.||||.|:| .||:||.:|.||||:|..||:|.
Human  1233 ---ADFQCFKQARAAGLLSTYRAFLSSHLQDLSTIVRKAERYSLPIVNLKGQVLFNNWDSIFSGH 1294

  Fly   913 GGFFSQAPRIYSFSGKNVMTDSTWPMKMVWHGSLPNGERSMDTYCDAWHSGDHLKGSFASNLDGH 977
            ||.|:....||||.|:::|||.:||.|::||||.|:|.|.:|.||:||.:.|......||.|...
Human  1295 GGQFNMHIPIYSFDGRDIMTDPSWPQKVIWHGSSPHGVRLVDNYCEAWRTADTAVTGLASPLSTG 1359

  Fly   978 KLLEQKRQSCDSKLIILCVE 997
            |:|:||..||.::||:||:|
Human  1360 KILDQKAYSCANRLIVLCIE 1379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mp	NP_001246651.1	LamG	58..222	CDD:473984	49/164 (30%)
		gly_rich_SclB	<292..>421	CDD:468478	58/211 (27%)
		gly_rich_SclB	<379..>616	CDD:468478	135/441 (31%)
		Collagen_trimer	744..792	CDD:466257	16/51 (31%)
		Endostatin-like	831..999	CDD:238151	85/167 (51%)
COL15A1	NP_001846.3	TSPN	40..228	CDD:214560	53/187 (28%)
		gly_rich_SclB	<624..>927	CDD:468478	107/306 (35%)
		gly_rich_SclB	<838..>1043	CDD:468478	55/205 (27%)
		Collagen_trimer	1135..1181	CDD:466257	15/45 (33%)
		Endostatin-like	1215..1381	CDD:238151	85/168 (51%)