DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mp and Col18a1

DIOPT Version :9

Sequence 1:	NP_001246651.1	Gene:	Mp / 38769	FlyBaseID:	FBgn0260660	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_006513236.1	Gene:	Col18a1 / 12822	MGIID:	88451	Length:	1774	Species:	Mus musculus

Alignment Length:	1374	Identity:	381/1374 - (27%)
Similarity:	507/1374 - (36%)	Gaps:	478/1374 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CTLLVPV-------LGSFELVGQSIKDALAE---------YTLTDIMNNNQFAGIEFGEAEDGFP 63
            |..:.|.       :|..:|:|..:.:.:::         |......|:.|.|...|
Mouse   479 CVFIGPAAENVAEEVGLLQLLGDPLPEKISQIDDPHVGPAYIFGPDSNSGQVAQYHF-------- 535

  Fly    64 AFRFLQTADVKSPYRMLLPEKLY--EFAILITFRQSSLKGGYLFSVVNPLDTVVQLGVHLSPVVK 126
                               .||:  :|::|...|.::...|.||::.:....||.|||.||.|..
Mouse   536 -------------------PKLFFRDFSLLFHVRPATEAAGVLFAITDAAQVVVSLGVKLSEVRD 581

  Fly   127 NSYNVSLVYTQADQNIGRKLASFGVAHVPDKWNSIALQVLSDKVSFYYDCELRNTTLVTREPIEL 191
            ...|:||:||:...:..:..|||.:.....:|...||.|....|:.|.|||........|....|
Mouse   582 GQQNISLLYTEPGASQTQTGASFRLPAFVGQWTHFALSVDGGSVALYVDCEEFQRVPFARASQGL 646

  Fly   192 VFDSASTLYIGQAGSIIGGKFEGYLEKINVYGNPDAINVTCM----------------------- 233
            ..:..:.|::||||:....||:|.:.::.|...|....|.|:
Mouse   647 ELERGAGLFVGQAGTADPDKFQGMISELKVRKTPRVSPVHCLDEEDDDEDRASGDFGSGFEESSK 711

  Fly   234 -------------PPPKATIAP-----TTADDGSIFYEGSGENILFEDSTEANILSDDFWNTG-- 278
                         .||..|..|     ||.|..:...|        ||:...:|.::....||
Mouse   712 SHKEDTSLLPGLPQPPPVTSPPLAGGSTTEDPRTEETE--------EDAAVDSIGAETLPGTGSS 768

  Fly   279 ---DEATDI----FDASGMQ----------PPGQ----------TQYTHERPYRGIKGEKGERGP 316
               |||...    ....||:          |||.          .|..:.:|..|.:|..|.:||
Mouse   769 GAWDEAIQNPGRGLIKGGMKGQKGEPGAQGPPGPAGPQGPAGPVVQSPNSQPVPGAQGPPGPQGP 833

  Fly   317 ------------------------------------------KGDSIRGPPGPPGPPGPKGETAP 339
                                                      |||...||.||||||||.|.:..
Mouse   834 PGKDGTPGRDGEPGDPGEDGRPGDTGPQGFPGTPGDVGPKGEKGDPGIGPRGPPGPPGPPGPSFR 898

  Fly   340 YPPFVETTSAGAKYTGECTCNASDILEAIKD-------------------------NESLRESLR 379
            ..........|:.::|:        :|:::.                         |.|......
Mouse   899 QDKLTFIDMEGSGFSGD--------IESLRGPRGFPGPPGPPGVPGLPGEPGRFGINGSYAPGPA 955

  Fly   380 GAPGTPGKDGKPGTP---------------------GHTGATGVPGARGARGSEGAQGLKGEPGV 423
            |.||.|||:|.||.|                     |..|..|:||.:|::|..|..|:.|:.|:
Mouse   956 GLPGVPGKEGPPGFPGPPGPPGPPGKEGPPGVAGQKGSVGDVGIPGPKGSKGDLGPIGMPGKSGL 1020

  Fly   424 DGLPGVMGPPGPPGPPGLP-----ENYDES--------LMVNSMGAFRGTT-------QPGAKGV 468
            .|.||.:||||||||||.|     ..:|:.        ....|....:|..       .||..|:
Mouse  1021 AGSPGPVGPPGPPGPPGPPGPGFAAGFDDMEGSGIPLWTTARSSDGLQGPPGSPGLKGDPGVAGL 1085

  Fly   469 PGEKGDAGQKGERGDP------GHKGAHGPSGAKGEPGEPGTP-----GLPGLPGQVGQPG---- 518
            ||.||:.|..|.:|.|      |..|:.||.|.||.|||.|.|     |.|||||..|.||
Mouse  1086 PGAKGEVGADGAQGIPGPPGREGAAGSPGPKGEKGMPGEKGNPGKDGVGRPGLPGPPGPPGPVIY 1150

  Fly   519 ------------------------------------GLDGLASANGTKGE--------------- 532
                                                |..||....|.|||
Mouse  1151 VSSEDKAIVSTPGPEGKPGYAGFPGPAGPKGDLGSKGEQGLPGPKGEKGEPGTIFSPDGRALGHP 1215

  Fly   533 -KGEKGEKGMRGRRG--------------------GT--------------------GATGPIGP 556
             ||.|||.|.||..|                    ||                    |..||.||
Mouse  1216 QKGAKGEPGFRGPPGPYGRPGHKGEIGFPGRPGRPGTNGLKGEKGEPGDASLGFSMRGLPGPPGP 1280

  Fly   557 PGKPGPMG-------DIGHSGRPGMTGPKGEMGPKGPKGDSG-----GREG------------LK 597
            ||.|||.|       ....|||||:.|.:|..||.|||||.|     |..|            :|
Mouse  1281 PGPPGPPGMPIYDSNAFVESGRPGLPGQQGVQGPSGPKGDKGEVGPPGPPGQFPIDLFHLEAEMK 1345

  Fly   598 GDKGDRGQDGRDGLPGPPGLPSTGGGDGDSGGVQYIPMPGPPGPPGPPGLP---GLSISGPKGEP 659
            |||||||..|:.|..|.||.|  |||...|.      :||||||||.||:|   |.||.||.|.|
Mouse  1346 GDKGDRGDAGQKGERGEPGAP--GGGFFSSS------VPGPPGPPGYPGIPGPKGESIRGPPGPP 1402

  Fly   660 GVDSRSSFFGDASYYGRPGARSSLDELKALRELQDLRDRPDGTAEPPRQPGHSHKHEETLGL--- 721
            |.......    .|.||.|                    |.|...||..|.....|.:|:.:
Mouse  1403 GPQGPPGI----GYEGRQG--------------------PPGPPGPPGPPSFPGPHRQTVSVPGP 1443

  Fly   722 -----VDGEEPYFSASSSNMNMKIVPGAVTFQNIDEMTKKSALNPPGTLAYITEEEALLVRVNKG 781
                 ..|......||:..:.:     ..|:|.   |..|....|.|.|.::.|.|.|.|||..|
Mouse  1444 PGPPGPPGPPGAMGASAGQVRI-----WATYQT---MLDKIREVPEGWLIFVAEREELYVRVRNG 1500

  Fly   782 WQYIAL--------GTLVPIATPAPP-----------------TTVAPSMRFDLQSKNLLNSP-- 819
            ::.:.|        ||...:|...||                 :|..|....|:    |.|.|
Mouse  1501 FRKVLLEARTALPRGTGNEVAALQPPLVQLHEGSPYTRREYSYSTARPWRADDI----LANPPRL 1561

  Fly   820 -------------------PP------LLNTPTWYPRMLRVAALNEPSTGDLQGIRGADFACYRQ 859
                               ||      |.:|...:..:|.:.|||.|.:|.::|||||||.|::|
Mouse  1562 PDRQPYPGVPHHHSSYVHLPPARPTLSLAHTHQDFQPVLHLVALNTPLSGGMRGIRGADFQCFQQ 1626

  Fly   860 GRRAGLLGTFKAFLSSRVQNLDTIVRPADR-DLPVVNTRGDVLFNSWKGIFNGQGGFFSQAPRIY 923
            .|..||.|||:||||||:|:|.:|||.||| .:|:||.:.:||..||..:|:|..|......||:
Mouse  1627 ARAVGLSGTFRAFLSSRLQDLYSIVRRADRGSVPIVNLKDEVLSPSWDSLFSGSQGQLQPGARIF 1691

  Fly   924 SFSGKNVMTDSTWPMKMVWHGSLPNGERSMDTYCDAWHSGDHLKGSFASNLDGHKLLEQKRQSCD 988
            ||.|::|:....||.|.|||||.|:|.|.|::||:.|.:........||:|...:|||||..||.
Mouse  1692 SFDGRDVLRHPAWPQKSVWHGSDPSGRRLMESYCETWRTETTGATGQASSLLSGRLLEQKAASCH 1756

  Fly   989 SKLIILCVE 997
            :..|:||:|
Mouse  1757 NSYIVLCIE 1765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mp	NP_001246651.1	LamG	58..222	CDD:304605	43/165 (26%)
		Collagen	378..432	CDD:189968	24/74 (32%)
		Collagen	464..518	CDD:189968	29/64 (45%)
		Collagen	494..615	CDD:189968	74/245 (30%)
		Endostatin-like	831..999	CDD:238151	80/168 (48%)
Col18a1	XP_006513236.1	DUF959	37..218	CDD:368758
		CRD_Collagen_XVIII	366..488	CDD:143564	2/8 (25%)
		TSPN	492..680	CDD:214560	52/214 (24%)
		Collagen	<840..875	CDD:189968	0/34 (0%)
		Collagen	1069..1128	CDD:189968	23/58 (40%)
		Collagen	1108..1197	CDD:189968	24/88 (27%)
		Collagen	1172..1265	CDD:189968	18/92 (20%)
		Endostatin	1463..1765	CDD:368935	109/313 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	182	1.000	Domainoid score	I3444
eggNOG	1	0.900	-	-		E1_KOG3546
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1362001at2759
OrthoFinder	1	1.000	-	-		FOG0002295
OrthoInspector	1	1.000	-	-		otm44160
orthoMCL	1	0.900	-	-		OOG6_106129
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3198
SonicParanoid	1	1.000	-	-		X1979
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.710