DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mp and Col15a1

DIOPT Version :9

Sequence 1:	NP_001246651.1	Gene:	Mp / 38769	FlyBaseID:	FBgn0260660	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_034058.2	Gene:	Col15a1 / 12819	MGIID:	88449	Length:	1367	Species:	Mus musculus

Alignment Length:	1472	Identity:	396/1472 - (26%)
Similarity:	540/1472 - (36%)	Gaps:	594/1472 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RVLQG--VMFALAMICTLLVPVLGSFELVGQSIKDALAEYTLTDIMNNNQFAGIEFGEAEDGFPA 64
            |..||  ..:.|::|..||..||.:....|.:   :.....||.::.....:.:.|.....||||
Mouse     5 RTAQGRRPRWLLSIISALLSAVLQTRAATGSA---SQVHLDLTVLIGVPLPSSVSFTTGYGGFPA 66

  Fly    65 FRFLQTADVKSPYRMLLPEKLY-EFAILITFRQSSLKGGYLFSVVNPLDTVVQLGVHLSPVVKNS 128
            :.|...|:|..|.|.|:|...: :|||.:..:.:|.:||.||::.:....|:.||:.||.|....
Mouse    67 YSFGPGANVGRPARTLIPPTFFRDFAIGVAVKPNSAQGGVLFAITDAFQKVIYLGLRLSSVEDGR 131

  Fly   129 YNVSLVYTQADQNIGRKLASFGVAHVPDKWNSIALQVLSDKVSFYYDCELRNTTLVTREPIELVF 193
            ..|.|.||:...::.|:.|.|.|..:.::||..|:.|..::|:.:.|||.::.....|....|.|
Mouse   132 QRVILYYTEPGSHVSREAAVFSVPVMTNRWNRFAVTVQGEEVALFMDCEEQSQVRFQRSSWPLTF 196

  Fly   194 DSASTLYIGQAGSIIGGKFEGYLEKINVYGNP-------------------------------DA 227
            :.::.:::|.||::...:|.|.::::.:|.:|                               :|
Mouse   197 EPSAGIFVGNAGAMGLERFTGSIQQLTIYSDPRTPEELCEAQESSASGEASGFQEMDEVAEIMEA 261

  Fly   228 INVTCMPPPKA-----TIAPTT---ADDGSIFYE---------------------GSGENILFED 263
            :..|..||.::     ::.||:   |:|..:..|                     ||||  :..|
Mouse   262 VTYTQAPPKESHVDPISVPPTSSSPAEDSELSGEPVPEGTPETNLSIIGHSSPEQGSGE--ILND 324

  Fly   264 STEANIL-----SDDFWNTGDEA----------------------TDIFDA-SGMQPPGQ----- 295
            :.|.:.:     :||  .:||.|                      |.:.:| :|..|.|.
Mouse   325 TLEVHAMDGDPGTDD--GSGDGALLNVTDGQGLSATATGEASVPVTTVLEAENGSMPTGSPTLAM 387

  Fly   296 -TQYTHE-------------------------------RPYRG--IK-------GEKGER----- 314
             ||...|                               .|..|  :|       |..||.
Mouse   388 FTQSIREVDTPDPENLTTTASGDGEVPTSTDGDTEADSSPTGGPTLKPREEATLGSHGEEWLTPA 452

  Fly   315 ----------------------------------------------------------------- 314

Mouse   453 VSKMPLKAFEEEEASGTAIDSLDVIFTPTVVLEQVSRRPTDIQATFTPTVVLEETSGAPTDTQDA 517

  Fly   315 ----------------------------------------------------------------G 315
                                                                            |
Mouse   518 LTPTVAPEQMFTAEPTDGGDLVASTEEAEEEGSGSMPPSGPPLPTPTVTPKRQVTLVGVEAEGSG 582

  Fly   316 PKG---------------DSIRGPPGPPGPPGPKGETAPYPPFVETTSAGAKYTGECTCNASDIL 365
            |.|               |.:|||||||||||..|  .|..|                  .:|:
Mouse   583 PVGGLDEGSGSGDIVGNEDLLRGPPGPPGPPGSPG--IPGKP------------------GTDV- 626

  Fly   366 EAIKDNESLRESLRGAPGTPGKDGKPGTPGHTGATGVP------------GARGARGSEGAQGLK 418
                        ..|.||:||:||.||.||..|..|.|            |.:||||..|:.|.|
Mouse   627 ------------FMGPPGSPGEDGAPGEPGPQGPEGQPGLDGASGQQGMKGEKGARGPNGSAGEK 679

  Fly   419 GEPGVDGL------------PGVMGPPGPPGPPGLP-------------ENYDESLMVNSMGAFR 458
            |:||..||            ||||||||||||||.|             .:.|..|:  |.....
Mouse   680 GDPGNRGLPGPPGKNGEVGTPGVMGPPGPPGPPGPPGPGCTTELGFEIEGSGDVRLL--SKPTIS 742

  Fly   459 GTTQPGAKGVPGEKGDAGQKGERGDPGHK-----GAHGPSG------------------------ 494
            |.|.|  .|..||||:.|.|||||..|..     |..||.|
Mouse   743 GPTSP--SGPKGEKGEQGAKGERGADGTSTMGPPGPRGPPGHVEVLSSSLINITNGSMNFSDIPE 805

  Fly   495 AKGEPGEPGTPGLPGLPGQVGQPGGLDGLASANGTKGEKGEKGEKG-----------MRGRRGGT 548
            ..|.||..|.|||||.||..| |.|..|:....|.|||:|||||.|           |:||:|..
Mouse   806 LMGPPGPDGVPGLPGFPGPRG-PKGDTGVPGFPGLKGEQGEKGEPGAILTGDVPLEMMKGRKGEP 869

  Fly   549 ---GATGPIGPPGKPGPMGDIGHSGRPG-----------------MTGPKGEMGPKGP------- 586
               ||.||:||.|.||..|:.|..||||                 :.||.|..||.||
Mouse   870 GIHGAPGPMGPKGPPGHKGEFGLPGRPGRPGLNGLKGAKGDRGVTLPGPPGLPGPPGPPGPPGAV 934

  Fly   587 ------------------------------------KGDSG--GREGLKGDKGDRGQDGRDGLP- 612
                                                ||:.|  |..|.||:|||:|..|..|.|
Mouse   935 VNIKGAVFPIPARPHCKTPVGTAHPGDPELVTFHGVKGEKGSWGLPGSKGEKGDQGAQGPPGPPV 999

  Fly   613 --------------------------------GPPGLPSTGGGDGDSGGVQYIPMPGPPGPPGPP 645
                                            ||||||...|..|..|..    :.||.||||.|
Mouse  1000 DPAYLRHFLNSLKGENEDASFRGESSNNLFVSGPPGLPGYPGLVGQKGEA----VVGPQGPPGIP 1060

  Fly   646 GLPG------LSISGPKGEPGVDSRSSFFGDA-SYYGRPGARSSLDELKALRELQDLRDRPDGTA 703
            ||||      ..:.||.|.||.....:..|.| :..|.||
Mouse  1061 GLPGPPGFGRPGVPGPPGPPGPPGPPAILGAAVALPGPPG------------------------- 1100

  Fly   704 EPPRQPGHSHKHEETLGLVDGEEPYFSASSSNMNMKIVPGA----VTFQNIDEMTKKSALNPPGT 764
             ||.|||                              :||:    ....::.:|.:|:.|...||
Mouse  1101 -PPGQPG------------------------------LPGSRNLVTALSDMGDMLQKAHLVIEGT 1134

  Fly   765 LAYITEEEALLVRVNKGWQYIALGTLVPIATPAPPTTVAPSMRFDLQSKNLLNSPP--PLLNTPT 827
            ..|:.:.....:||..||:.:.||.|:||...:||.....|..:..|       ||  |:|:..
Mouse  1135 FIYLRDSGEFFIRVRDGWKKLQLGELIPIPADSPPPPALSSNPYQPQ-------PPLNPILSAN- 1191

  Fly   828 WYPR-MLRVAALNEPSTGDLQGIRGADFACYRQGRRAGLLGTFKAFLSSRVQNLDTIVRPADR-D 890
             |.| :|.:.|||.|..||::    |||.|::|.|.||||.||:|||||.:|:|.|:||.|:| .
Mouse  1192 -YERPVLHLVALNTPVAGDIR----ADFQCFQQARAAGLLSTFRAFLSSHLQDLSTVVRKAERFG 1251

  Fly   891 LPVVNTRGDVLFNSWKGIFNGQGGFFSQAPRIYSFSGKNVMTDSTWPMKMVWHGSLPNGERSMDT 955
            ||:||.:|.||||:|..||:|.||.|:....||||.|::||||.:||.|:|||||.|:|.|.:|.
Mouse  1252 LPIVNLKGQVLFNNWDSIFSGDGGQFNTHIPIYSFDGRDVMTDPSWPQKVVWHGSNPHGVRLVDK 1316

  Fly   956 YCDAWHSGDHLKGSFASNLDGHKLLEQKRQSCDSKLIILCVE 997
            ||:||.:.|.....|||.|...|:|:||..||.::||:||:|
Mouse  1317 YCEAWRTTDMAVTGFASPLSTGKILDQKAYSCANRLIVLCIE 1358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mp	NP_001246651.1	LamG	58..222	CDD:304605	49/164 (30%)
		Collagen	378..432	CDD:189968	31/77 (40%)
		Collagen	464..518	CDD:189968	28/82 (34%)
		Collagen	494..615	CDD:189968	67/253 (26%)
		Endostatin-like	831..999	CDD:238151	89/169 (53%)
Col15a1	NP_034058.2	TSPN	42..228	CDD:214560	53/185 (29%)
		Nonhelical region 1 (NC1)	229..604		38/378 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..319		8/51 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..446		4/49 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..784		83/291 (29%)
		Triple-helical region 1 (COL1)	605..718		56/145 (39%)
		Collagen	638..691	CDD:189968	21/52 (40%)
		Nonhelical region 2 (NC2)	719..748		6/32 (19%)
		Triple-helical region 2 (COL2)	749..783		16/33 (48%)
		Nonhelical region 3 (NC3)	784..807		0/22 (0%)
		Triple-helical region 3 (COL3)	808..852		25/44 (57%)
		Collagen	822..912	CDD:189968	35/90 (39%)
		Nonhelical region 4 (NC4)	853..863		0/9 (0%)
		Triple-helical region 4 (COL4)	864..934		25/69 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	905..930		7/24 (29%)
		Nonhelical region 5 (NC5)	935..968		0/32 (0%)
		Triple-helical region 5 (COL5)	969..998		13/28 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	974..1000		12/25 (48%)
		Nonhelical region 6 (NC6)	999..1031		0/31 (0%)
		Triple-helical region 6 (COL6)	1032..1086		25/57 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1055..1089		14/33 (42%)
		Nonhelical region 7 (NC7)	1087..1096		2/8 (25%)
		Triple-helical region 7 (COL7)	1097..1111		10/69 (14%)
		Nonhelical region 8 (NC8)	1112..1367		113/260 (43%)
		Endostatin-like	1194..1360	CDD:238151	89/169 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	182	1.000	Domainoid score	I3444
eggNOG	1	0.900	-	-		E1_KOG3546
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1396
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1362001at2759
OrthoFinder	1	1.000	-	-		FOG0002295
OrthoInspector	1	1.000	-	-		otm44160
orthoMCL	1	0.900	-	-		OOG6_106129
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9126
SonicParanoid	1	1.000	-	-		X1979
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.710