DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mp and col21a1

DIOPT Version :9

Sequence 1:	NP_001246651.1	Gene:	Mp / 38769	FlyBaseID:	FBgn0260660	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_002664126.4	Gene:	col21a1 / 100333837	ZFINID:	ZDB-GENE-110607-3	Length:	968	Species:	Danio rerio

Alignment Length:	790	Identity:	226/790 - (28%)
Similarity:	299/790 - (37%)	Gaps:	237/790 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GFPAFRFLQTADVKSPYRMLLPEKL---YEFAILITFRQS-SLKGGYLFSV------------VN 109
            |..|::.....|:....|||.|..|   |.|...:.::.| :::...|:.:            :|
Zfish   259 GSKAYQVTSRDDLSESTRMLFPGGLPPSYVFVATLKYKGSVAIEEWDLWRIQTKDEKPQMAVSLN 323

  Fly   110 PLDTVVQLGVHLSPVVKNSYNVSLVYTQADQNIGRKLASFGVAHVPDKWNSIALQVLSDKVSFYY 174
            .||..|......|.....:..|  |:|::.   .:||       ..:||:.:.|.|..:.|:.|.
Zfish   324 GLDRTVMFTTTTSKTPSGTQTV--VFTKSP---AKKL-------FDEKWHQLRLLVTEEDVTLYV 376

  Fly   175 DCELRNTTLVTREPIELVFDSASTLYIGQAGSIIGGK----FEGYLEKINVYGNPDAIN--VTCM 233
            | :|...||.. ||.:.:|.:..|    |.|..:..:    ||  ::|:.:|.:|:..|  ..|.
Zfish   377 D-DLEIETLAL-EPPDGIFINGKT----QVGKYVSKETTVPFE--VQKLRIYCDPEQNNRETACE 433

  Fly   234 ----------------PPPKATIAPTTADDGSIFYEG-SGENILFEDSTEANILSDDFWNTGDEA 281
                            |.|:..|.|    .|.....| :||.....|..:......|    |...
Zfish   434 IPGVDGECANGPGDIDPTPEPCICP----PGPPGTPGMTGERGKMGDPGQPGPAGAD----GKPG 490

  Fly   282 TDIFDAS-GMQPPGQTQYTHERPYRGIKGEKGERGPKGDSIRGPPGPPGPPGPKGETAPYPPFVE 345
            ...|..| |:|  |......:|...|.|||||..|..||  ||.||.|||||..||..
Zfish   491 VPGFRGSPGIQ--GSPGIEGQRGADGHKGEKGSPGEAGD--RGIPGLPGPPGKTGEKG------- 544

  Fly   346 TTSAGAKYTGECTCNASDILEAIKDNESLRESLRGAPGTPGKDGK---------PGTPGHTGATG 401
              |||.                           :|..|.|||||:         .|.||:.|..|
Zfish   545 --SAGN---------------------------QGIQGPPGKDGQTGEKGSRGLAGPPGYPGEPG 580

  Fly   402 VPGARGARGSEGAQGLKGEPGVDGLPGVMGPPGPPGPPGLPENYDESLMVNSMGAFRGTTQPGAK 466
            .||..|..|:.||.||||:||..|:||:.|..|.||.||:|.| |....:.......|:  .|||
Zfish   581 APGRDGKDGAPGAIGLKGDPGPPGIPGLDGREGHPGMPGIPGN-DGQRGIKGEAGLSGS--KGAK 642

  Fly   467 GVPGEKGD---AGQKGERGDPGHKGAHGPSGAKGEPGEPGTPGLPGLPGQVGQPG--GLDGLASA 526
            |:||:.|:   .|..|..|.||.||..|.||..|:.|.||..|.||..|..||||  |:.|....
Zfish   643 GIPGDAGEMGLPGMTGSSGQPGPKGNKGESGESGQAGPPGPEGKPGADGPSGQPGHPGMPGSLGM 707

  Fly   527 NGTKGEKGEKGEKGMRGRRGGTGATGPIGPPGKPGPMGDIGHSGRP---------GMTGPKGEMG 582
            .|.:|:.||:|..||:|.||.:|..|..|.||..|..|:.|.:|.|         |:.|.:|:.|
Zfish   708 KGQRGDTGERGADGMKGERGDSGRPGGHGLPGAAGKKGEKGTAGEPGQSGLNGHQGLPGQRGQTG 772

  Fly   583 PKGPKGDSG--------------GRE--------------------------------------- 594
            |.||:|.||              |||
Zfish   773 PSGPRGQSGEIGHPGPPGPEGRPGREMSEQHIQQICRDILRSEIPALLLSSQHSQHRSCEHCYTR 837

  Fly   595 ----------------GLKGDKGDRGQDGRDGLPGPPGLPSTGGGDGDSG-----GVQYIPMPGP 638
                            |..|..|..|..|:.||||.||:|...|..|:.|     |...|..||.
Zfish   838 VGPPGPVGTPGPHGPRGFPGLSGSNGLQGQRGLPGRPGVPGMKGDPGEKGDKGSQGRSVIGDPGL 902

  Fly   639 PGPPGPPGLPGLSISGPKGEPGVDSRSSFFGDASYYGRPGARSSLDELKALRELQDLRDRPDGTA 703
            ||||||.|..|:...|..|:|         |...:.|:.|.|                    |.:
Zfish   903 PGPPGPTGPAGVGKPGQAGKP---------GSPGHEGKEGKR--------------------GQS 938

  Fly   704 EPPRQPGHSH 713
            ..|.|||..|
Zfish   939 GEPGQPGVCH 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mp	NP_001246651.1	LamG	58..222	CDD:304605	41/180 (23%)
		Collagen	378..432	CDD:189968	27/62 (44%)
		Collagen	464..518	CDD:189968	27/56 (48%)
		Collagen	494..615	CDD:189968	57/200 (29%)
		Endostatin-like	831..999	CDD:238151
col21a1	XP_002664126.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910