DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mp and col7a1

DIOPT Version :9

Sequence 1:	NP_001246651.1	Gene:	Mp / 38769	FlyBaseID:	FBgn0260660	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_009300870.1	Gene:	col7a1 / 100332562	ZFINID:	ZDB-GENE-030131-2427	Length:	3112	Species:	Danio rerio

Alignment Length:	468	Identity:	180/468 - (38%)
Similarity:	220/468 - (47%)	Gaps:	69/468 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 GMQPPGQTQYTHERPYRGIKGEKGERGPKGDSI----RGPP--GPPGPPGPKGETAPYPPFVETT 347
            |...||......||..||..|..|.:|.|||:.    ||.|  |.||.|||||:.....|...:.
Zfish  1649 GSSDPGSFGRKGERGERGFPGPAGAKGDKGDAAQKGERGAPGAGEPGQPGPKGDQGDRGPGGLSG 1713

  Fly   348 SAGAKYT-------GECTCNASDILEAIKDNESLRESLRGAPGTPGKDGKPGTPGHTGATGVPGA 405
            ..|||.:       ||.....|......:..:.|:.. :|..|..|:.|.||.||..|..|:||.
Zfish  1714 KPGAKGSQGDAGERGEAGSPGSQGPMGPRGKDGLKGD-KGEDGIAGEPGLPGKPGERGLRGLPGQ 1777

  Fly   406 RGARGSEGAQGLKGEPGVDGLPGVMGP---------PGPPGPPGLPENYDESLMVNSMGAFRGTT 461
            .|..|::|..|..||.|.:|.||.|||         .||||||| .....|..:....|......
Zfish  1778 SGQPGTKGDTGDPGEDGRNGTPGTMGPRGPKGDQGIQGPPGPPG-DVTTGEKQLRGEKGEKGEAG 1841

  Fly   462 QPGAKGVPGEKGDAGQKGERGDPGHKGAHGPSGAKGEPGEPGTP---------GLPGLPGQVGQP 517
            .||..|..|.||:||.:|..|..|.:|..|..||:|:||:.|:|         ||.|.|||.|:|
Zfish  1842 DPGEHGAKGLKGEAGAQGTAGSSGPEGQRGLPGARGDPGDRGSPGEKGERGAAGLDGRPGQDGKP 1906

  Fly   518 G--GLDGLASANGTKGEKGEKGEKGMRGRRGGTGATGPIGPP---GKPGPMGDIGHSGRPGMTGP 577
            |  |..||   .|..|::|:.|..|:.|.||..|..||.|||   |.||..|:.|.||.||.||.
Zfish  1907 GPPGPPGL---RGDPGKQGDPGRDGLAGLRGPQGPPGPPGPPGADGTPGKAGEDGKSGLPGKTGE 1968

  Fly   578 KGEMGPKGPKGDSG--------GREGLKGDKGDRGQDGRDGLPGPPGLPSTGGGDGDSGGVQYI- 633
            .|..|..|.|||.|        ||:|:|||:|..|..|..|..||||:|   |..|..|.|.|:
Zfish  1969 DGVPGEDGRKGDKGEQGPAGRDGRDGIKGDRGIAGPSGPQGPVGPPGVP---GNVGPPGSVVYVK 2030

  Fly   634 ---PMPGPPGPPGPPGLPGL----SISGPKGEPGVDSRSSFFGDASYYGRPGARSSLDELKAL-- 689
               ..||||||.||||.||:    ...|.:||.|:.......||....|:||  :|.|..:||
Zfish  2031 GEPATPGPPGPQGPPGTPGIPGVPGAGGARGERGLPGLKGDVGDPGEDGKPG--TSADVKRALSD 2093

  Fly   690 -----RELQDLRD 697
                 |||:.|.|
Zfish  2094 FGIEVRELKQLVD 2106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mp	NP_001246651.1	LamG	58..222	CDD:304605
		Collagen	378..432	CDD:189968	23/53 (43%)
		Collagen	464..518	CDD:189968	26/62 (42%)
		Collagen	494..615	CDD:189968	62/142 (44%)
		Endostatin-like	831..999	CDD:238151
col7a1	XP_009300870.1	vWFA	33..196	CDD:294047
		fn3	225..309	CDD:278470
		FN3	335..409	CDD:238020
		FN3	415..495	CDD:238020
		FN3	505..577	CDD:214495
		fn3	592..660	CDD:278470
		FN3	680..>740	CDD:238020
		FN3	776..854	CDD:238020
		fn3	862..938	CDD:278470
		fn3	953..1021	CDD:278470
		fn3	1040..1120	CDD:278470
		VWA	1134..1300	CDD:278519
		Collagen	1335..1393	CDD:189968
		Collagen	1405..1462	CDD:189968
		Collagen	1450..1511	CDD:189968
		Collagen	1483..1553	CDD:189968
		Collagen	1586..1644	CDD:189968
		Collagen	1653..1708	CDD:189968	23/54 (43%)
		Collagen	1692..1749	CDD:189968	16/56 (29%)
		Collagen	1725..1782	CDD:189968	17/57 (30%)
		Collagen	1758..1809	CDD:189968	23/50 (46%)
		Collagen	1835..1894	CDD:189968	21/58 (36%)
		Collagen	2120..2180	CDD:189968
		Collagen	2156..2216	CDD:189968
		Collagen	2243..2297	CDD:189968
		Collagen	2276..2330	CDD:189968
		Collagen	2362..2420	CDD:189968
		Collagen	2410..2473	CDD:189968
		Collagen	2457..2518	CDD:189968
		Collagen	2596..2657	CDD:189968
		Collagen	2661..2724	CDD:189968
		Collagen	2704..2761	CDD:189968
		Collagen	2734..2792	CDD:189968
		Collagen	2788..2846	CDD:189968
		KU	3057..3110	CDD:238057
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910