Protein Alignment bin and FHL1

DIOPT Version :10

• Sequence 1: NP_523950.2
• Gene: bin / 38766
• FlyBaseID: FBgn0045759
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_015429.1
• Gene: FHL1 / 856219
• SGDID: S000006308
• Length: 936
• Species: Saccharomyces cerevisiae
• Alignment Length: 744
• Identity: 151/744 - (20%)
• Similarity: 244/744 - (32%)
• Gaps: 255/744 - (34%)

  Fly    70 PTELIDEKPNIGYMELKHYMDATPTATPVSAAQHYSLSALHSMGTPPASSSPIPPYGVLMTAHSA 134
            || |:|||.|:.:|.       ..:.||:...||      ..:|.||.::
Yeast   212 PT-LVDEKNNMLHMR-------NNSITPIMFQQH------ELVGQPPQNT--------------- 247

  Fly   135 GSASPQSNSKTPTDLPQDLQYASSSTSTAKVQPLQVQLQPLNHQYASTIKYCSNNTILSANDYQL 199
               ..::||   ||        :.:|.....:|:...| ||.::..:...|       :..|:|.
Yeast   248 ---VTENNS---TD--------AETTQRKLSEPIDASL-PLPNEQPTIFAY-------ARLDFQS 290

  Fly   200 LTSQEQA-----GQQQPQQLPAQQLQHSPGGGYMSRISTSPSQVISNAHGMPVLNYSSSSSS--- 256
            .|...|.     |::.....           .:...::..||:.||..|.....|:.:....
Yeast   291 FTFYVQTLHAIIGRRSENDF-----------SHKVDVNLGPSKSISRRHAQIFYNFGTGRFELSI 344

  Fly   257 --------------------------------------PAKSLNGSESSPPSQNHLENKVS---- 279
                                                  |.:..|....||.:.:..|::::
Yeast   345 IGKNGAFVDDIFVEKGNTVPLRNKTKIQIGQIPFQFILPEQERNDDSKSPENADIAESEINTRNL 409

  Fly   280 -----GSAVVGTGGSSQQDAPSTPDTTK-KSGTRRPE--------------KPALSYINMIGHAI 324
                 .|....|.|:..:.|.:.|...| |...:.|:              ||.:||..|:...|
Yeast   410 KKNEPKSKKKITTGAKPKKAQTKPAVKKEKKPPKIPKKVYTLEEIPVEYRTKPTVSYSAMLTTCI 474

  Fly   325 KESPTGK-LTLSEIYAYLQKSYEFFRGPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWT 388
            ::..|.| ::||||||.:::.:.:::....||::|||||||||:.|:|      |.|.|||..|.
Yeast   475 RKYSTAKGMSLSEIYAGIRELFPYYKYCPDGWQSSVRHNLSLNKSFRK------VSKEGKGWLWG 533

  Fly   389 IDEN-----------------------SAHLFEDEGSLRRRP-RG------YRSKIKVKPY---- 419
            :||.                       ...|.:.:..|::.| ||      .||.:..:..
Yeast   534 LDEEYIAERERQKKKQSEIAVAKAQAAQLKLEQQQHKLQQVPQRGKKDIVSQRSNVNARKQNISQ 598

  Fly   420 ---AGHANGYYASGYGDAGMDNG---NYYASP-AFASYDYSAAGATGVSPAGGQGFADPWN--AH 475
               |..|    ||...:...||.   .|.... ...:.|........::....|..|...|  ..
Yeast   599 TLAANRA----ASNRKNTASDNQRTMKYLQEQLVILTRDRKGLSKQVIAAILTQALAMTINQVTQ 659

  Fly   476 AAHSGSSSVGVGMGVGPL-------PQYTNISCLAAGGNVNGSATTP--------PLAHSALGMA 525
            ||.:      .|:...||       ||:.|: .|||..|...:..|.        |...:|..:|
Yeast   660 AAKN------KGITGNPLTALMDKNPQHLNL-ILAAAVNAATAKVTKGEVKQLVNPETTAAAALA 717

  Fly   526 PSASSSS---SPLGAAATLQSDYAP---------TASLVAAGYSYATSAGSLD------------ 566
            ..|..|.   .|:     :|:.:.|         :||.....|.:....||.|
Yeast   718 AKAQHSKPIRQPI-----VQTPHVPDRPPSQLSASASSHPNNYLHDKQPGSFDPSSLSRFFQPRQ 777

  Fly   567 --NGLRSISLQQLPGLSSIQHAQAQAQ---AQAHHHHHQHHASHPSHSHQGHGSMHQN------- 619
              ....|::...:|..:| |:..||.:   ||.:....:...|..|.|....||...:
Yeast   778 NARATSSVAATSVPAAAS-QNVDAQPKPKPAQDNDLESESGTSSSSSSSSESGSESDSGSDDGSA 841

  Fly   620 --HGTSSTTPPPSQSGGSHGIDHSPIDRK 646
              .|.:|:|...|:|....|   |.:|.|
Yeast   842 SGSGDNSSTSSESESESDSG---SEVDEK 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bin	NP_523950.2	FH_FOX	312..391	CDD:469596	32/79 (41%)
FHL1	NP_015429.1	COG5025	18..739	CDD:227358	123/610 (20%)