DRSC/TRiP Functional Genomics Resources

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Protein Alignment bin and Foxo1

DIOPT Version :10

Sequence 1:NP_523950.2 Gene:bin / 38766 FlyBaseID:FBgn0045759 Length:676 Species:Drosophila melanogaster
Sequence 2:NP_001178775.1 Gene:Foxo1 / 84482 RGDID:620283 Length:649 Species:Rattus norvegicus


Alignment Length:607 Identity:138/607 - (22%)
Similarity:201/607 - (33%) Gaps:233/607 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 PVLNYS-SSSSSPAKSLNGSESSPP------------SQNHLEN-----------------KVSG 280
            |..|.| |::||||.|  ||.::.|            |.:.:.|                 .|:.
  Rat    30 PEFNQSNSTTSSPAPS--GSTAANPDATASLASASAVSTDFMSNLSLLEESEDFARAPGCVAVAA 92

  Fly   281 SAVVGTG--GSSQ-------QDAPSTPDTT----------------------KKSGTRRPEKPAL 314
            :|....|  |..|       ..||..|..|                      |.|.:||.....|
  Rat    93 AAAASRGLCGDFQGPEAGCVHSAPPQPPPTGPLSQPPPVPPAAAGPLAGQPRKTSSSRRNAWGNL 157

  Fly   315 SYINMIGHAIKESPTGKLTLSEIYAYLQKSYEFFR-----GPYVGWKNSVRHNLSLNECFKKLPK 374
            ||.::|..||:.|...:||||:||.::.||..:|:     ....|||||:||||||:..|.:: :
  Rat   158 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRV-Q 221

  Fly   375 GMGVGKPGKGNYWTID-----------ENSAHLFEDEGSLRRRPRGYRSKIKVKPYAGHANGYYA 428
            ..|.   ||.::|.::           ..:|.:  |..|...:.||..:|.|....:|.      
  Rat   222 NEGT---GKSSWWMLNPEGGKSGKSPRRRAASM--DNNSKFAKSRGRAAKKKASLQSGQ------ 275

  Fly   429 SGYGDA-GMDNGNYYASPAFASYDYSAAGATGVSPAGGQGFADPWNAHAAHSGSSSVGVGMGVGP 492
            .|.||: |.....:.|||...|.|               .| |.|:.....:.|::..:...:.|
  Rat   276 EGPGDSPGSQFSKWPASPGSHSND---------------DF-DNWSTFRPRTSSNASTISGRLSP 324

  Fly   493 LPQYTNISCLAAGGNVNGSATTPPLAHSALGMAPSASS----------------SSSPLGAAATL 541
            :  .|....| ..|:|: |...||.|.......||.|.                .|||.....:.
  Rat   325 I--MTEQDDL-GDGDVH-SLVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVST 385

  Fly   542 QSD----------YA---PTASLVA-----AGYSYATSAGS------------------------ 564
            ||.          |:   |..||.:     |.|:|..|:.|                        
  Rat   386 QSSPGSMMQQTPCYSFAPPNTSLNSPSPNYAKYTYGQSSMSPVPQMPMQTLQDSKSSYGGLNQYN 450

  Fly   565 -----------------------LDNGL-----RSISLQQLPGLSSIQHAQAQAQAQAHHHHHQH 601
                                   :|.|:     |.:....|.|.:|:..|..   :||.|:...:
  Rat   451 CAPGLLKELLTSDSPPHNDIMSPVDPGVAQPNSRVLGQNVLMGPNSVMPAYG---SQAPHNKMMN 512

  Fly   602 HASHPSHSHQGHGSMHQNHGTSSTTPPPSQSGGSHGIDH--------SPIDR-KPAYLP---PIS 654
            .:   ||:|.||...     |||.        ....:.|        |.::| .|...|   |:|
  Rat   513 PS---SHTHPGHAQQ-----TSSV--------NGRALPHVVNTMPHTSAMNRLTPVKTPLQVPLS 561

  Fly   655 PPPMMVALNGGGGYYEGLKYAN 676
            .|..|.||    |.|..:...|
  Rat   562 HPMQMSAL----GNYSSVSSCN 579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
binNP_523950.2 FH_FOX 312..391 CDD:469596 32/94 (34%)
Foxo1NP_001178775.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62 12/33 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..151 6/38 (16%)
FH_FOXO1 145..243 CDD:410834 36/101 (36%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 205..212 5/6 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 228..339 27/138 (20%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 228..231 0/2 (0%)
Nuclear localization signal. /evidence=ECO:0000250 245..247 0/1 (0%)
Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0 277..557 62/318 (19%)
Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0 357..453 15/95 (16%)
FOXO_KIX_bdg 417..498 CDD:465228 10/80 (13%)
Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0 456..460 0/3 (0%)
FOXO-TAD 591..627 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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