DRSC/TRiP Functional Genomics Resources

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Protein Alignment bin and foxo1a

DIOPT Version :10

Sequence 1:NP_523950.2 Gene:bin / 38766 FlyBaseID:FBgn0045759 Length:676 Species:Drosophila melanogaster
Sequence 2:NP_001070725.2 Gene:foxo1a / 768121 ZFINID:ZDB-GENE-061013-59 Length:652 Species:Danio rerio


Alignment Length:650 Identity:145/650 - (22%)
Similarity:224/650 - (34%) Gaps:229/650 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   146 PTDLPQDLQYASSSTSTAKVQPLQVQLQPLNHQYASTIKYCSNNTILSAN-DYQ-----LLTSQE 204
            |...|:....|::.::|:...| .|:.:|     :||..:.:|.::|..| ||.     :|.|:.
Zfish    28 PLPRPEFPNPAAADSNTSSPAP-SVKQEP-----SSTADFINNLSLLEENEDYPDQKPLMLCSEF 86

  Fly   205 QAGQQ--QPQQLPAQQLQHSPGGGYMSRISTSPSQVISNAHGMPVLNYSSSSSSPAKSLNGSESS 267
            |..:.  ..||:|:||.|                        :|||      |||.         
Zfish    87 QCQENCIHQQQIPSQQQQ------------------------VPVL------SSPV--------- 112

  Fly   268 PPSQNHLENKVSGSAVVGTGGSSQQDAPSTPDTTKKSGTRRPEKPALSYINMIGHAIKESPTGKL 332
                         :|......::|:         |.|.:||.....:||.::|..||:.||..:|
Zfish   113 -------------AAAAAAAAAAQR---------KSSSSRRNAWGNMSYADLITKAIESSPEKRL 155

  Fly   333 TLSEIYAYLQKSYEFFR-----GPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTID-- 390
            |||:||.::.||..:|:     ....|||||:||||||:..|.:: :..|.   ||.::|.::  
Zfish   156 TLSQIYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFIRV-QNEGT---GKSSWWMLNPE 216

  Fly   391 ---------ENSAHLFEDEGSLRRRPRGYRSKIKVKPYAGHANGYYASG--YG-----DAGMDNG 439
                     ..:|.:  |..|...:.||..:|.|:....|...|..:.|  ||     .....|.
Zfish   217 GGKSGKSPRRRAASM--DNNSKFAKSRGRAAKKKLALQGGPEGGADSPGSQYGKWPGSPNSHSND 279

  Fly   440 NYYASPAFASYDYSAAGATG------------------VSPAGGQG--------FADPWNAHAAH 478
            ::.|..||.....|.|....                  |.|..|.|        ..........|
Zfish   280 DFEAWTAFRPRTSSNASTLSGRLSPFIDDELGDSDVHMVYPGPGSGTKMTSTLPSLSEMAGSLGH 344

  Fly   479 SGSSSVGVGMGVGPLPQYTNISCL-----AAGGNVNGSATTPPLAHSALGMAPSASSSSSPLGAA 538
            |||.:|...:       ..|::.|     :.||..:||..:.|  .|.:..:|..|..||| |.:
Zfish   345 SGSENVMENL-------LDNLNLLSPKNPSTGGPGSGSNQSSP--SSLMQASPGYSPYSSP-GLS 399

  Fly   539 AT---LQSDY---------------APTASLVAAGYSYATSAGSLDN-----GLRSISLQQL--- 577
            |.   .|.|:               .|...|..:..|:....|::..     ||    |::|   
Zfish   400 AVSQQTQQDFRKCLYGQAGMGSMSPMPMQPLPESKPSFGPGGGTMGQFNCTAGL----LKELLTS 460

  Fly   578 ---PG--LSSIQHAQAQA----------------QAQAHHHHHQHHASHPSHSHQ---------- 611
               ||  :.|:....:|:                :.......|.|..|||.:.|.          
Zfish   461 DGEPGDLMPSVDTVVSQSAGGSGCMLPPYSSGRNELMGGGPTHSHTLSHPHNMHGQAPPTSVALN 525

  Fly   612 ----------GHGSMHQNHGTSSTTPPPSQSGGSHGIDHSPIDRKPAYLPPISPPPMMVALNGGG 666
                      ||.|:....| |..:|...|.|||            .:|....||...::.||.|
Zfish   526 GRSLHPLTAIGHSSVGGRLG-SGKSPMQMQYGGS------------GHLGGGLPPYCSMSSNGYG 577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
binNP_523950.2 FH_FOX 312..391 CDD:469596 32/94 (34%)
foxo1aNP_001070725.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..57 7/34 (21%)
FH_FOXO1 125..223 CDD:410834 36/101 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 208..277 13/70 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 359..406 14/49 (29%)
FOXO_KIX_bdg 411..497 CDD:465228 12/89 (13%)
FOXO-TAD 593..631 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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