DRSC/TRiP Functional Genomics Resources

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Protein Alignment bin and FOXO4

DIOPT Version :10

Sequence 1:NP_523950.2 Gene:bin / 38766 FlyBaseID:FBgn0045759 Length:676 Species:Drosophila melanogaster
Sequence 2:NP_005929.2 Gene:FOXO4 / 4303 HGNCID:7139 Length:505 Species:Homo sapiens


Alignment Length:480 Identity:106/480 - (22%)
Similarity:165/480 - (34%) Gaps:148/480 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   257 PAKSLNGSESSPP-------SQNHLENK----VSGSAVVGTGGSSQQDAPSTPDTTKKSGTRRPE 310
            |...:....|.||       .:.|.|.:    :..|.:....|..|..........:|.|:||..
Human    36 PRPEIANQPSEPPEVEPDLGEKVHTEGRSEPILLPSRLPEPAGGPQPGILGAVTGPRKGGSRRNA 100

  Fly   311 KPALSYINMIGHAIKESPTGKLTLSEIYAYLQKSYEFFR-----GPYVGWKNSVRHNLSLNECFK 370
            ....||..:|..||:.:|..:|||::||.::.::..:|:     ....|||||:||||||:..|.
Human   101 WGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFI 165

  Fly   371 KLPKGMGVGKPGKGNYWTID-----------ENSAHLFEDEGSLRRRPRGYRSKIKVKPYAGHAN 424
            |:..    ...||.::|.::           ..:|.:......||.|.:..:.|..|.|      
Human   166 KVHN----EATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLLRGRSKAPKKKPSVLP------ 220

  Fly   425 GYYASGYGDAGMDNGNYYASPAFASYDYSAAGATGVSPAG------------GQGFADPWNAHAA 477
                              |.|         .|||..||.|            .:..||.|.....
Human   221 ------------------APP---------EGATPTSPVGHFAKWSGSPCSRNREEADMWTTFRP 258

  Fly   478 HSGSSSVGVGMGVGPLPQYTNISCLAAGGNVNGSA-TTPPLAHSALGMAPSASSSSSPLGAAATL 541
            .|.|::..|...:.||...:.:.......:|:..| ..||..:..|.:....:.:||        
Human   259 RSSSNASSVSTRLSPLRPESEVLAEEIPASVSSYAGGVPPTLNEGLELLDGLNLTSS-------- 315

  Fly   542 QSDYAPTASLVAAGYSYATSAGSLDNGLRSISLQQLPGLSSIQHAQAQAQAQAHHHHHQHHASHP 606
                   .||::.            :||...|||. ||::...|..:.:....        |..|
Human   316 -------HSLLSR------------SGLSGFSLQH-PGVTGPLHTYSSSLFSP--------AEGP 352

  Fly   607 SHSHQGHGSMHQNHG---TSSTTPPP------------SQS------GG---------SHGIDHS 641
            ..:.:|..|..|...   ||.|.|||            ||:      ||         ..|:...
Human   353 LSAGEGCFSSSQALEALLTSDTPPPPADVLMTQVDPILSQAPTLLLLGGLPSSSKLATGVGLCPK 417

  Fly   642 PIDRK-PAYLPP----ISPPPMMVA 661
            |::.. |:.|.|    |:|||:|.:
Human   418 PLEAPGPSSLVPTLSMIAPPPVMAS 442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
binNP_523950.2 FH_FOX 312..391 CDD:469596 28/94 (30%)
FOXO4NP_005929.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..100 13/63 (21%)
FH_FOXO4 98..183 CDD:410836 29/88 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 176..246 16/102 (16%)
FOXO_KIX_bdg <358..393 CDD:465228 10/34 (29%)
FOXO-TAD 465..503 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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