DRSC/TRiP Functional Genomics Resources

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Protein Alignment bin and FOXK2

DIOPT Version :10

Sequence 1:NP_523950.2 Gene:bin / 38766 FlyBaseID:FBgn0045759 Length:676 Species:Drosophila melanogaster
Sequence 2:NP_004505.2 Gene:FOXK2 / 3607 HGNCID:6036 Length:660 Species:Homo sapiens


Alignment Length:638 Identity:148/638 - (23%)
Similarity:235/638 - (36%) Gaps:153/638 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 GHPYRAGNLLTGGNYQAMGGGESP-----TELIDEKPNIGYMELKHYM----DATPTATPVSAAQ 102
            |.|...|....||   |.|||..|     ..|  |.....|:..|..:    :::..:..||...
Human    12 GTPPAGGGAGGGG---AGGGGSPPGGWAVARL--EGREFEYLMKKRSVTIGRNSSQGSVDVSMGH 71

  Fly   103 HYSLSALH-SMGTPPASSSPIPPYGVLMTAHSAGSASPQSNSKTP-TDLPQDLQYASSSTSTAKV 165
            ...:|..| .:.|||...           .|  |.|:|:.....| .|...|........:...|
Human    72 SSFISRRHLEIFTPPGGG-----------GH--GGAAPELPPAQPRPDAGGDFYLRCLGKNGVFV 123

  Fly   166 QPL--QVQLQPLNHQYASTIKYCSNNTILSANDYQLLTSQEQAGQQQPQQLPAQQLQHSPGGGYM 228
            ..:  :....||......|.::.|.|..::   :..|:| |:..:|:..:.|.:.:|     .::
Human   124 DGVFQRRGAPPLQLPRVCTFRFPSTNIKIT---FTALSS-EKREKQEASESPVKAVQ-----PHI 179

  Fly   229 SRIS--------------TSPSQVISNAHGMPVLNYSSSSSSPAKSLNGSESS-------PPSQN 272
            |.::              .||:..||.|:..|        |||    .|:.||       .||..
Human   180 SPLTINIPDTMAHLISPLPSPTGTISAANSCP--------SSP----RGAGSSGYKVGRVMPSDL 232

  Fly   273 HL--ENKVSGSAVVGTGGSSQQDAPSTPDTTKKSGTRRPEKPALSYINMIGHAIKESPTGKLTLS 335
            :|  :|....:....:||.|.:|               ..||..||..:|..||..:|..:|||:
Human   233 NLMADNSQPENEKEASGGDSPKD---------------DSKPPYSYAQLIVQAITMAPDKQLTLN 282

  Fly   336 EIYAYLQKSYEFFRGPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTIDENSAHLFEDE 400
            .||.::.|:|.::|....||:||:|||||||..|.|:|:..  .:||||::|.||..|.....::
Human   283 GIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQ--EEPGKGSFWRIDPASESKLIEQ 345

  Fly   401 GSLRRRPRG---YRSKIKVKPYAGHANGYYASGYGDAGMDNGNYYASPAFASYDYSAAGATGVSP 462
            ...:|||||   :|:.:          |..:|....|..::....::.:..:....:....| ||
Human   346 AFRKRRPRGVPCFRTPL----------GPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREG-SP 399

  Fly   463 AGGQ---GFADPWNA--HAAHSGSSSVGVGMGVGP--------LPQYTNISCLAAGGNVNGSATT 514
            |..:   |.|.|..|  ..|....|:.|..:...|        |||............|..|.:.
Human   400 APLEPEPGAAQPKLAVIQEARFAQSAPGSPLSSQPVLITVQRQLPQAIKPVTYTVATPVTTSTSQ 464

  Fly   515 PPLAHS--ALGMAPSASSSSSPLGAAATLQSDYAPTASLVAAGYSYATSAGSLDNGLRSISLQQL 577
            ||:..:  .:...|:.|         .|..:..||..:...:|.:..|.|..|            
Human   465 PPVVQTVHVVHQIPAVS---------VTSVAGLAPANTYTVSGQAVVTPAAVL------------ 508

  Fly   578 PGLSSIQHAQAQAQAQAHHHHHQHHAS---HPSHSHQGHGSMHQNHGTSSTTP 627
                    |..:|:||.:..|.:....   .|:..|...|:..:...|:.|||
Human   509 --------APPKAEAQENGDHREVKVKVEPIPAIGHATLGTASRIIQTAQTTP 553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
binNP_523950.2 FH_FOX 312..391 CDD:469596 35/78 (45%)
FOXK2NP_004505.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 10/26 (38%)
FHA_FOXK2 35..157 CDD:438775 24/139 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 85..104 6/31 (19%)
Required for interaction with DVL2 and SUDS3. /evidence=ECO:0000269|PubMed:25805136 129..171 9/45 (20%)
COG5025 <180..577 CDD:227358 108/443 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..260 19/83 (23%)
FH_FOXK2 256..353 CDD:410829 40/98 (41%)
DNA-binding, major groove. /evidence=ECO:0000269|PubMed:16624804 300..318 12/17 (71%)
DNA-binding, minor groove. /evidence=ECO:0000269|PubMed:16624804 328..332 2/3 (67%)
DNA-binding, minor groove. /evidence=ECO:0000269|PubMed:16624804 348..353 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 359..407 8/58 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..632
Blue background indicates that the domain is not in the aligned region.

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