Protein Alignment bin and FOXA1

DIOPT Version :9

• Sequence 1: NP_523950.2
• Gene: bin / 38766
• FlyBaseID: FBgn0045759
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_004487.2
• Gene: FOXA1 / 3169
• HGNCID: 5021
• Length: 472
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 130/552 - (23%)
• Similarity: 204/552 - (36%)
• Gaps: 159/552 - (28%)

  Fly   176 NHQYASTIKYCSN----------NTILSANDYQLLTSQEQAGQQQPQQ-------------LPAQ 217
            |..||.|.:..|:          .::.|.|.|..:.:...:|...|..             |...
Human    16 NSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMTPASFNMSYANPGLGAGLSPG 80

  Fly   218 QLQHSPGGGYMSRISTSPSQVISNAHGMPVLNYSSSSSSPAKSLNGSESSPPSQNHLENKVS--- 279
            .:...|||...:..|.:.:.|.:....:......:..:..|.|:||......:.|...:.::
Human    81 AVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGAMGAQQAASMNGLGPYAAAMNPCMSPMAYAP 145

  Fly   280 ---GSAVVGTGGSSQQDAPSTPDTTKKSGTRRPEKPALSYINMIGHAIKESPTGKLTLSEIYAYL 341
               |.:..|.||.::....|.|..          ||..|||::|..||:::|:..|||||||.::
Human   146 SNLGRSRAGGGGDAKTFKRSYPHA----------KPPYSYISLITMAIQQAPSKMLTLSEIYQWI 200

  Fly   342 QKSYEFFRGPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTIDENSAHLFEDEGSLRRR 406
            ...:.::|.....|:||:||:||.|:||.|:.:  ...|||||:|||:..:|.::||:...|||:
Human   201 MDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVAR--SPDKPGKGSYWTLHPDSGNMFENGCYLRRQ 263

  Fly   407 PRGYRSKIKVKPYAGHANGYYASGYGDAGMDNG-NYYASPAFASYDYSAA-------GATGV--- 460
            .   |.|.:.:|.||...|   ||.|.:|...| .....|:.||...:.:       |.||.
Human   264 K---RFKCEKQPGAGGGGG---SGSGGSGAKGGPESRKDPSGASNPSADSPLHRGVHGKTGQLEG 322

  Fly   461 SPAGGQGFADPWNAHAAHSGSSSVGVGMGVGPLPQYTNISCLAAGGNVNGSATTPPLAHSALGMA 525
            :||.|.. |.|....  |||:::.|   |...|             ....|:|.||:
Human   323 APAPGPA-ASPQTLD--HSGATATG---GASEL-------------KTPASSTAPPI-------- 360

  Fly   526 PSASSSSSPLGAAATLQSDYAPTASLVAAGYSYATSAGSLDNGLRSISLQQLPGLSSIQHAQAQA 590
                 ||.| ||.|::.:.:.                                     .|..|..
Human   361 -----SSGP-GALASVPASHP-------------------------------------AHGLAPH 382

  Fly   591 QAQAHHHHHQHHA-SHPSHSHQGHGSMHQNHGT--------------SSTTPPPSQSGGSHGIDH 640
            ::|.|.....|:: :||...:....|..|.|..              .||.|.....|.:.....
Human   383 ESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQYSPYGSTLPASLPLGSASVTTR 447

  Fly   641 SPIDRKPAYLPPISPPPMMVALNGGGGYYEGL 672
            |||:  |:.|.|              .||:|:
Human   448 SPIE--PSALEP--------------AYYQGV 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bin	NP_523950.2	Forkhead	311..399	CDD:278670	38/87 (44%)
FOXA1	NP_004487.2	Forkhead_N	17..169	CDD:369872	26/151 (17%)
		FH_FOXA1	157..268	CDD:410812	46/125 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	269..392		40/195 (21%)
		HNF_C	398..461	CDD:401339	16/78 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910